2020
Kidney tissue hypoxia dictates T cell–mediated injury in murine lupus nephritis
Chen PM, Wilson PC, Shyer JA, Veselits M, Steach HR, Cui C, Moeckel G, Clark MR, Craft J. Kidney tissue hypoxia dictates T cell–mediated injury in murine lupus nephritis. Science Translational Medicine 2020, 12 PMID: 32269165, PMCID: PMC8055156, DOI: 10.1126/scitranslmed.aay1620.Peer-Reviewed Original ResearchConceptsHypoxia-inducible factor-1Lupus nephritisT cellsTissue hypoxiaT-cell-mediated injuryCell-mediated injuryHIF-1 blockadeKidney tissue hypoxiaSystemic lupus erythematosusHuman lupus nephritisMurine lupus nephritisRenal injuryAutoimmune injuryLupus erythematosusAutoimmune diseasesImmune cellsRenal tissueMurine modelTissue damageMore hypoxicNephritisInjuryLow oxygen tensionOxygen tensionFactor 1
2012
The pathogenesis of systemic lupus erythematosus—an update
Choi J, Kim ST, Craft J. The pathogenesis of systemic lupus erythematosus—an update. Current Opinion In Immunology 2012, 24: 651-657. PMID: 23131610, PMCID: PMC3508331, DOI: 10.1016/j.coi.2012.10.004.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusLupus erythematosusAberrant adaptive immune responseAdaptive immune responsesDisease-specific therapeutic targetsInnate immune mechanismsPathogenic autoantibodiesImmune mechanismsTissue injuryImmune responseTherapeutic targetB cellsDisease mechanismsErythematosusClinical biologyRecent studiesAutoantibodiesLupusSLEPathogenesisInjury
1995
Molecular Structure and Function of Autoantigens in Systemic Sclerosis
Lee B, Craft J. Molecular Structure and Function of Autoantigens in Systemic Sclerosis. International Reviews Of Immunology 1995, 12: 129-144. PMID: 7650417, DOI: 10.3109/08830189509056708.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, NuclearAutoantigensChromosomal Proteins, Non-HistoneDNA HelicasesDNA Topoisomerases, Type IDNA-Binding ProteinsDNA-Directed RNA PolymerasesEndoribonucleasesExoribonucleasesExosome Multienzyme Ribonuclease ComplexHumansKinetochoresKu AutoantigenNuclear ProteinsPol1 Transcription Initiation Complex ProteinsRibonucleoproteinsScleroderma, SystemicTranscription Factors