2016
The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity
Chan PY, Carrera Silva EA, De Kouchkovsky D, Joannas LD, Hao L, Hu D, Huntsman S, Eng C, Licona-Limón P, Weinstein JS, Herbert DR, Craft JE, Flavell RA, Repetto S, Correale J, Burchard EG, Torgerson DG, Ghosh S, Rothlin CV. The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity. Science 2016, 352: 99-103. PMID: 27034374, PMCID: PMC4935984, DOI: 10.1126/science.aaf1358.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAnimalsAsthmaBlood ProteinsDendritic CellsDisease Models, AnimalGene Knockout TechniquesHost-Parasite InteractionsHumansImmunity, InnateInterleukin-4MiceMice, Inbred C57BLMice, KnockoutNippostrongylusProtein SPyroglyphidaeReceptor Protein-Tyrosine KinasesStrongylida InfectionsT-LymphocytesConceptsType 2 immunityType 2 responsesType 2 cytokinesHuman dendritic cellsInnate immune cellsDendritic cellsAllergic diseasesImmune cellsT cellsAdaptive immunityInterleukin-4Host responseFunctional neutralizationGenetic ablationReceptor tyrosine kinasesImmunityProtective functionTyro3Tyrosine kinaseNegative regulatorPROS1CellsResponseCytokinesDisease
2010
Epstein‐Barr virus promotes interferon‐α production by plasmacytoid dendritic cells
Quan TE, Roman RM, Rudenga BJ, Holers VM, Craft JE. Epstein‐Barr virus promotes interferon‐α production by plasmacytoid dendritic cells. Arthritis & Rheumatism 2010, 62: 1693-1701. PMID: 20178121, PMCID: PMC2885535, DOI: 10.1002/art.27408.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, NuclearDendritic CellsDose-Response Relationship, ImmunologicEnzyme-Linked Immunosorbent AssayFlow CytometryHerpesvirus 4, HumanHumansImmunity, HumoralInterferon-alphaLupus Erythematosus, SystemicMajor Histocompatibility ComplexStatistics, NonparametricToll-Like Receptor 7Toll-Like Receptor 9ConceptsPlasmacytoid dendritic cellsSystemic lupus erythematosusHuman plasmacytoid dendritic cellsIFNalpha productionDendritic cellsEpstein-Barr virus infectionToll-like receptor 9Interferon-alpha levelsPresence of EBVChronic viral infectionsElevated viral loadAbility of EBVInnate immune cellsEpstein-Barr virusMajor histocompatibility complex moleculesInnate immune responseEnzyme-linked immunosorbent assayHistocompatibility complex moleculesSLE patientsEBV DNATLR-7Lupus erythematosusViral loadReceptor 9Immune cells