2002
IL-10 Regulates Murine Lupus
Yin Z, Bahtiyar G, Zhang N, Liu L, Zhu P, Robert ME, McNiff J, Madaio MP, Craft J. IL-10 Regulates Murine Lupus. The Journal Of Immunology 2002, 169: 2148-2155. PMID: 12165544, DOI: 10.4049/jimmunol.169.4.2148.Peer-Reviewed Original ResearchConceptsIL-10Murine lupusHuman systemic lupus erythematosusAnti-dsDNA autoantibody productionSeverity of lupusTh1 cytokine responseAnti-dsDNA autoantibodiesSystemic lupus erythematosusIFN-gamma productionIL-10 locusMRL/MpJPotential therapeutic benefitLupus syndromeSevere glomerulonephritisSevere lupusLupus modelsLupus erythematosusRIL-10Autoantibody productionCytokine responsesHuman lupusSerum concentrationsProtective effectSkin lesionsLittermate controls
1998
Autoimmune-Associated Congenital Heart Block: Demographics, Mortality, Morbidity and Recurrence Rates Obtained From a National Neonatal Lupus Registry
Buyon J, Hiebert R, Copel J, Craft J, Friedman D, Katholi M, Lee L, Provost T, Reichlin M, Rider L, Rupel A, Saleeb S, Weston W, Skovron M. Autoimmune-Associated Congenital Heart Block: Demographics, Mortality, Morbidity and Recurrence Rates Obtained From a National Neonatal Lupus Registry. Journal Of The American College Of Cardiology 1998, 31: 1658-1666. PMID: 9626848, DOI: 10.1016/s0735-1097(98)00161-2.Peer-Reviewed Original ResearchConceptsCongenital heart blockNeonatal lupus syndromeSSA/RoWeeks of gestationRecurrence rateLa antibodiesSubsequent pregnancySSA/Ro-SSB/La antibodiesAutoantibody-associated congenital heart blockDevelopment of CHBAnti-SSB/La antibodiesAnti-SSA/RoIsolated congenital heart blockClose echocardiographic monitoringLate second trimesterDays of lifeSSB/LaSufficient medical recordsMajor structural abnormalitiesMaternal autoantibodiesLupus syndromeNeonatal lupusEchocardiographic monitoringLupus RegistryHeart block
1996
Propagation and regulation of systemic autoimmunity by gammadelta T cells.
Peng SL, Madaio MP, Hayday AC, Craft J. Propagation and regulation of systemic autoimmunity by gammadelta T cells. The Journal Of Immunology 1996, 157: 5689-98. PMID: 8955223, DOI: 10.4049/jimmunol.157.12.5689.Peer-Reviewed Original ResearchConceptsGammadelta T cellsAlphabeta T cellsT cellsRenal diseaseMurine lupusSystemic autoimmunityImmune complex renal diseaseT cell-intact miceRoles of alphabetaT-cell-deficient animalsLupus-prone miceSevere renal diseaseComplex renal diseaseLupus syndromeAutoantibody productionConventional CD4Polyclonal expansionPathogenic roleMiceHypergammaglobulinemiaDisease phenotypeAutoimmunityLupusDiseaseCellsT cells in murine lupus: propagation and regulation of disease
Peng S, Craft J. T cells in murine lupus: propagation and regulation of disease. Molecular Biology Reports 1996, 23: 247-251. PMID: 9112236, DOI: 10.1007/bf00351176.Peer-Reviewed Original ResearchConceptsΓδ T cellsΑβ T cellsT cellsLupus syndromeRenal diseaseMurine lupusCell helpMRL/lpr B cellsMRL/Mp-lpr/lpr miceImmune complex renal diseaseT cell-dependent mechanismLupus-prone MRL miceClass-switched autoantibodiesClass-switched immunoglobulinsSpecific autoimmune responseT-cell-deficient animalsCell-dependent mechanismB cell helpLpr B cellsT cell helpComplex renal diseaseB cell autoimmunityWild-type animalsPathogenesis of diseaseCause tissue injury