2000
Conditional up-regulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies
Nagaraju K, Raben N, Loeffler L, Parker T, Rochon P, Lee E, Danning C, Wada R, Thompson C, Bahtiyar G, Craft J, van Huijsduijnen R, Plotz P. Conditional up-regulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 9209-9214. PMID: 10922072, PMCID: PMC16847, DOI: 10.1073/pnas.97.16.9209.Peer-Reviewed Original ResearchConceptsMHC class IMyositis-specific autoantibodiesClass IAutoimmune diseasesSkeletal muscleHuman inflammatory myopathiesHuman myositisInflammatory myopathiesAutoimmune myositisImmunological featuresSpontaneous human diseaseYoung miceAutoantibodiesMuscle cellsNonspecific eventsDiseaseMiceMyositisMuscleCommon specificityHuman diseasesSpecific patternsSpecificityStimuliMyopathy
1996
Autoantibodies to glycyl–transfer RNA synthetase in myositis. Association with dermatomyositis and immunologic heterogeneity
Hirakata M, Suwa A, Takeda Y, Matsuoka Y, Irimajiri S, Targoff I, Hardin J, Craft J. Autoantibodies to glycyl–transfer RNA synthetase in myositis. Association with dermatomyositis and immunologic heterogeneity. Arthritis & Rheumatism 1996, 39: 146-151. PMID: 8546723, DOI: 10.1002/art.1780390119.Peer-Reviewed Original ResearchConceptsTRNA synthetase antibodiesImmunologic heterogeneitySynthetase antibodiesTransfer RNA synthetase antibodiesPolymyositis/dermatomyositisInterstitial lung diseaseIdentification of antibodiesRheumatic diseasesLung diseaseClinical significanceEpitope specificityPatientsAutoantibodiesImmunoblotting findingsSerumAntibodiesDiseaseDermatomyositisMyositisRNA synthetaseImmunoprecipitation assaysAssociationGlycyl-tRNA synthetaseSpecificityFindings