2012
Caspase‐activated DNase is required for maintenance of tolerance to lupus nuclear autoantigens
Jog NR, Frisoni L, Shi Q, Monestier M, Hernandez S, Craft J, Prak ET, Caricchio R. Caspase‐activated DNase is required for maintenance of tolerance to lupus nuclear autoantigens. Arthritis & Rheumatism 2012, 64: 1247-1256. PMID: 22127758, PMCID: PMC3292632, DOI: 10.1002/art.33448.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusAutoimmune responseMouse modelApoptotic cellsNuclear autoantigensDNA antibody titersLupus-prone miceAbsence of CADMaintenance of toleranceAutoreactive B cellsAnti-DNA antibodiesApoptotic modificationsLupus developmentGeneration of autoantigensAntinuclear antibodiesLupus erythematosusAntibody titersAutoimmune diseasesActive caspase-3Apoptotic bodiesB cellsMiceAutoantigensCAD deficiencyCaspase-3
2001
From T to B and back again: positive feedback in systemic autoimmune disease
Shlomchik M, Craft J, Mamula M. From T to B and back again: positive feedback in systemic autoimmune disease. Nature Reviews Immunology 2001, 1: 147-153. PMID: 11905822, DOI: 10.1038/35100573.Peer-Reviewed Original ResearchConceptsSystemic autoimmune diseaseAutoimmune diseasesPrototypical systemic autoimmune diseaseSystemic lupus erythematosusPerpetuation of autoimmunityLoss of toleranceAutoantigen targetsLupus erythematosusAutoimmune stateB cellsImmune systemNuclear autoantigensDiseaseErythematosusAutoimmunityAutoantigens
1991
PBC 95K, a 95‐kilodalton nuclear autoantigen in primary biliary cirrhosis
Evans J, Reuben A, Craft J. PBC 95K, a 95‐kilodalton nuclear autoantigen in primary biliary cirrhosis. Arthritis & Rheumatism 1991, 34: 731-736. PMID: 2053918, DOI: 10.1002/art.1780340614.Peer-Reviewed Original ResearchConceptsPrimary biliary cirrhosisAntinuclear antibodiesBiliary cirrhosisANA-positive samplesConnective tissue diseaseSera of patientsANA-positive seraHEp-2 cellsPBC patientsLiver diseaseTissue diseaseNuclear dotsPatientsIndirect immunofluorescenceNuclear autoantigensStaining patternAffinity-purified antibodiesSerumAntibodiesCirrhosisDiseaseAutoantigensTiters