2011
Migrating out of the zone: the role of P-selectin glycoprotein ligand-1 on T follicular helper cell movement (60.8)
Hernandez S, Weinstein J, Steiner L, Bertino S, Poholek A, Gallagher P, Craft J. Migrating out of the zone: the role of P-selectin glycoprotein ligand-1 on T follicular helper cell movement (60.8). The Journal Of Immunology 2011, 186: 60.8-60.8. DOI: 10.4049/jimmunol.186.supp.60.8.Peer-Reviewed Original ResearchTfh cellsB cell folliclesT cell zonesGerminal centersT cellsLymphoid organsImmune responseB cellsFollicular helper T cellsTD immune responsesT-cell infiltratesChemokine receptor expressionHelper T cellsSecondary lymphoid organsCell zoneMemory B cellsDependent immune responsesGC B cellsWild-type controlsAdoptive transferCell infiltrateLymph nodesP-selectin glycoprotein ligand-1Plasma cell developmentDeficient miceCharacterization of different subsets of human follicular helper T (TFH) cells (152.9)
Choi J, Kim S, Lainez B, Craft J. Characterization of different subsets of human follicular helper T (TFH) cells (152.9). The Journal Of Immunology 2011, 186: 152.9-152.9. DOI: 10.4049/jimmunol.186.supp.152.9.Peer-Reviewed Original ResearchFollicular helper T cellsB cell folliclesHelper T cellsTfh cellsT cellsIL-21P-selectin glycoprotein ligand-1IL-4Germinal centersB cellsTonsillar Tfh cellsIL-17 secretionExpression of CD127B cell helpAntigen-specific antibodiesGC B cellsTh17 cellsTfh subsetsPD-1Effector subsetsCell helpTherapeutic targetBCL-6RORC expressionHuman tonsils
2010
In Vivo Regulation of Bcl6 and T Follicular Helper Cell Development
Poholek AC, Hansen K, Hernandez SG, Eto D, Chandele A, Weinstein JS, Dong X, Odegard JM, Kaech SM, Dent AL, Crotty S, Craft J. In Vivo Regulation of Bcl6 and T Follicular Helper Cell Development. The Journal Of Immunology 2010, 185: 313-326. PMID: 20519643, PMCID: PMC2891136, DOI: 10.4049/jimmunol.0904023.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CommunicationCell DifferentiationCricetinaeDNA-Binding ProteinsDown-RegulationFemaleImmunophenotypingLymphocyte CooperationMembrane GlycoproteinsMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutMice, TransgenicProto-Oncogene Proteins c-bcl-6SpleenT-Lymphocyte SubsetsT-Lymphocytes, Helper-InducerUp-RegulationConceptsPD-1 upregulationIL-21IL-6B cellsFollicular helper T cellsFollicular helper cell developmentDeath receptor-1Helper T cellsCytokines IL-6B cell interactionsB cell maturationTranscriptional repressor BCL6Vivo regulationCell developmentP-selectin glycoprotein ligand-1New surface markersT cellsGerminal centersInitial upregulationReceptor 1CXCR5BCL6 upregulationCell maturationSurface markersBCL6 expression
2009
Bcl6 is required for the development of T follicular helper cells marked by downregulation of P-selectin glycoprotein ligand-1 (46.7)
Poholek A, Hernandez S, Chandele A, Dong X, Odegard J, Kaech S, Dent A, Craft J. Bcl6 is required for the development of T follicular helper cells marked by downregulation of P-selectin glycoprotein ligand-1 (46.7). The Journal Of Immunology 2009, 182: 46.7-46.7. DOI: 10.4049/jimmunol.182.supp.46.7.Peer-Reviewed Original ResearchTfh cellsP-selectin glycoprotein ligand-1IL-21PD-1T cellsFollicular helper T cellsAbsence of ICOSExpression of CXCR5Follicular helper cellsTfh cell developmentHelper T cellsLigand 1B cell maturationTranscriptional repressor BCL6ICOS signalingNew surface markersHelper cellsGerminal centersB cellsCell maturationSurface markersExpression of BCL6BCL6CXCR5Downregulation
2008
ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity
Odegard JM, Marks BR, DiPlacido LD, Poholek AC, Kono DH, Dong C, Flavell RA, Craft J. ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity. Journal Of Experimental Medicine 2008, 205: 2873-2886. PMID: 18981236, PMCID: PMC2585848, DOI: 10.1084/jem.20080840.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteAutoimmunityCell DifferentiationChemokinesDisease Models, AnimalGerminal CenterImmunoglobulin Class SwitchingImmunoglobulin GInducible T-Cell Co-Stimulator ProteinInterleukinsLupus Erythematosus, SystemicMembrane GlycoproteinsMiceMice, KnockoutPlasma CellsReceptors, CXCR4T-Lymphocyte SubsetsT-Lymphocytes, Helper-InducerConceptsEffector T cellsT cellsIL-21IgG productionCXC chemokine receptor 4 (CXCR4) expressionB cell helper functionFollicular helper T cellsChemokine receptor 4 expressionReceptor 4 expressionCD4 T cellsHelper T cellsMRL/MpJAutoimmune strainsP-selectin glycoprotein ligand-1Autoantibody productionChronic autoimmunitySystemic autoimmunityPlasma cellsExtrafollicular responseExtrafollicular sitesMouse modelGerminal centersHelper functionSelective lossLigand 1CD4 T Cells That Promote Extrafollicular B Cell Responses
Poholek A, Odegard J, Craft J. CD4 T Cells That Promote Extrafollicular B Cell Responses. The FASEB Journal 2008, 22: 846.3-846.3. DOI: 10.1096/fasebj.22.1_supplement.846.3.Peer-Reviewed Original ResearchCD4 T cellsExtrafollicular B cell responsesB cell responsesIL-21T cellsLO cellsP-selectin glycoprotein ligand-1Extrafollicular sitesTCR transgenic CD4 T cellsCell responsesSelectin glycoprotein ligand-1Follicular helper T cellsTransgenic CD4 T cellsT FH cellsB cell folliclesHelper T cellsNormal immune responseExtrafollicular cellsAdoptive transferMurine lupusFH cellsIL-4Extrafollicular responseImmune responseNovel subset