2010
Epstein‐Barr virus promotes interferon‐α production by plasmacytoid dendritic cells
Quan TE, Roman RM, Rudenga BJ, Holers VM, Craft JE. Epstein‐Barr virus promotes interferon‐α production by plasmacytoid dendritic cells. Arthritis & Rheumatism 2010, 62: 1693-1701. PMID: 20178121, PMCID: PMC2885535, DOI: 10.1002/art.27408.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, NuclearDendritic CellsDose-Response Relationship, ImmunologicEnzyme-Linked Immunosorbent AssayFlow CytometryHerpesvirus 4, HumanHumansImmunity, HumoralInterferon-alphaLupus Erythematosus, SystemicMajor Histocompatibility ComplexStatistics, NonparametricToll-Like Receptor 7Toll-Like Receptor 9ConceptsPlasmacytoid dendritic cellsSystemic lupus erythematosusHuman plasmacytoid dendritic cellsIFNalpha productionDendritic cellsEpstein-Barr virus infectionToll-like receptor 9Interferon-alpha levelsPresence of EBVChronic viral infectionsElevated viral loadAbility of EBVInnate immune cellsEpstein-Barr virusMajor histocompatibility complex moleculesInnate immune responseEnzyme-linked immunosorbent assayHistocompatibility complex moleculesSLE patientsEBV DNATLR-7Lupus erythematosusViral loadReceptor 9Immune cells
2006
CHAPTER 28 Systemic Lupus Erythematosus: Immunologic Features
KANG I, CRAFT J. CHAPTER 28 Systemic Lupus Erythematosus: Immunologic Features. 2006, 357-367. DOI: 10.1016/b978-012595961-2/50031-7.Peer-Reviewed Original ResearchSystemic lupus erythematosusPlasmacytoid dendritic cellsT cellsAdaptive immunityImmune complexesAberrant innate immune responsesAdaptive immune cellsUpregulation of IFNSubsequent tissue injuryPeripheral blood cellsInnate immune responseActivation of complementRespective autoantigensDendritic cellsLupus erythematosusData support rolesImmune cellsSerologic hallmarkTissue injuryClinical diseaseImmune responseTarget organsFc receptorsB cellsImmune system