2023
HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease
Little A, Chen P, Vesely M, Khan R, Fiedler J, Garritano J, Islam F, McNiff J, Craft J. HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease. JCI Insight 2023, 8: e166076. PMID: 37526979, PMCID: PMC10543720, DOI: 10.1172/jci.insight.166076.Peer-Reviewed Original ResearchConceptsCutaneous lupus erythematosusLupus skin diseaseT cellsSkin diseasesCytotoxic signatureInflammatory infiltrateHIF-1Tissue damageKidney-infiltrating T cellsSkin-infiltrating T cellsAutoimmune skin diseaseHIF-1 inhibitionSkin tissue damageLupus erythematosusSystemic diseaseTissue inflammationGranzyme BMouse modelInflammatory gene programDiseaseProtein levelsInfiltratesSkin environmentGene programPresent study
1993
Autoantigenic epitopes of the B and D polypeptides of the U1 snRNP. Analysis of domains recognized by the Y12 monoclonal anti-Sm antibody and by patient sera.
Hirakata M, Craft J, Hardin JA. Autoantigenic epitopes of the B and D polypeptides of the U1 snRNP. Analysis of domains recognized by the Y12 monoclonal anti-Sm antibody and by patient sera. The Journal Of Immunology 1993, 150: 3592-601. PMID: 7682245, DOI: 10.4049/jimmunol.150.8.3592.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibodies, MonoclonalAutoantigensBinding Sites, AntibodyEnzyme-Linked Immunosorbent AssayEpitopesHumansImmune SeraLupus Erythematosus, SystemicMiceMolecular Sequence DataProtein ConformationRibonucleoprotein, U1 Small NuclearRibonucleoproteins, Small NuclearSnRNP Core ProteinsConceptsAnti-Sm antibodiesMonoclonal anti-Sm antibodyPatient seraCross-reactive epitopesAutoantigenic epitopesAnti-Sm seraPolypeptide BD polypeptideAnti-Sm patient seraSerumSpecific markersSm small nuclear ribonucleoproteinsEpitopesEnd deletionsAntibodiesImmunoreactive sitesCorresponding synthetic peptideB'/BMAbsDeletion studiesPresent studyLittle amino acid sequence homologySynthetic peptidesAmino acid sequence homologySLE