Systemic autoimmunity in LGJ mice
Peng S, Madaio M, Craft J. Systemic autoimmunity in LGJ mice. Immunology Letters 1996, 53: 153-155. PMID: 9024995, DOI: 10.1016/s0165-2478(96)02616-8.Peer-Reviewed Original ResearchConceptsLG/J miceJ miceAnalysis of autoimmunityEnd-organ diseaseNon-diseased animalsAntinuclear antibodiesInterstitial nephritisLupus erythematosusRenal diseaseRheumatoid factorCutaneous diseaseSystemic autoimmunityMurine modelControl animalsJ strainJ backgroundAutoimmunityDiseaseMiceAutoantibodiesUseful modelAnimalsErythematosusPerivasculitisGlomerulonephritisA tumor-suppressor function for Fas (CD95) revealed in T cell-deficient mice.
Peng SL, Robert ME, Hayday AC, Craft J. A tumor-suppressor function for Fas (CD95) revealed in T cell-deficient mice. Journal Of Experimental Medicine 1996, 184: 1149-1154. PMID: 9064331, PMCID: PMC2192794, DOI: 10.1084/jem.184.3.1149.Peer-Reviewed Original ResearchConceptsAlpha beta T cellsGamma delta T cellsBeta T cellsTumor suppressorDelta T cellsT cellsTumor suppressor functionCentral regulatory moleculeLethal B-cell lymphomaT cell-deficient miceB cell dysregulationCell-deficient miceRegulatory moleculesDevelopment of lymphomaB-cell lymphomaTumor regulationFas functionHematopoietic cellsFunctional FasRheumatoid factorCell dysregulationMalignant tumorsCell lymphomaIdentifies rolesImmunoglobulin MAutoimmune lpr/lpr mice deficient in CD40 ligand: spontaneous Ig class switching with dichotomy of autoantibody responses.
Ma J, Xu J, Madaio MP, Peng Q, Zhang J, Grewal IS, Flavell RA, Craft J. Autoimmune lpr/lpr mice deficient in CD40 ligand: spontaneous Ig class switching with dichotomy of autoantibody responses. The Journal Of Immunology 1996, 157: 417-26. PMID: 8683147, DOI: 10.4049/jimmunol.157.1.417.Peer-Reviewed Original ResearchConceptsLpr/lpr miceLpr miceIgG autoantibodiesAutoantibody responseCD40 ligandAutoimmune lpr/lpr miceMRL/Mp-lpr/lpr miceHuman systemic lupus erythematosusSystemic lupus erythematosusAge 3 moIgG rheumatoid factorB cell contactSubset of animalsOvert glomerulonephritisLupus erythematosusIgG2b levelsHistologic evidenceRheumatoid factorSerum IgMAb synthesisAutoantibodiesLpr animalsMiceIg classesElevated levels