2012
The pathogenesis of systemic lupus erythematosus—an update
Choi J, Kim ST, Craft J. The pathogenesis of systemic lupus erythematosus—an update. Current Opinion In Immunology 2012, 24: 651-657. PMID: 23131610, PMCID: PMC3508331, DOI: 10.1016/j.coi.2012.10.004.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusLupus erythematosusAberrant adaptive immune responseAdaptive immune responsesDisease-specific therapeutic targetsInnate immune mechanismsPathogenic autoantibodiesImmune mechanismsTissue injuryImmune responseTherapeutic targetB cellsDisease mechanismsErythematosusClinical biologyRecent studiesAutoantibodiesLupusSLEPathogenesisInjuryIL-7Rαlow memory CD8+ T cells are significantly elevated in patients with systemic lupus erythematosus
Kim JS, Cho BA, Sim JH, Shah K, Woo CM, Lee EB, Lee DS, Kang JS, Lee WJ, Park CG, Craft J, Kang I, Kim HR. IL-7Rαlow memory CD8+ T cells are significantly elevated in patients with systemic lupus erythematosus. Rheumatology 2012, 51: 1587-1594. PMID: 22661557, PMCID: PMC3418646, DOI: 10.1093/rheumatology/kes100.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntibodies, BlockingAntigens, CDCD8-Positive T-LymphocytesCoculture TechniquesCytotoxicity, ImmunologicFemaleFlow CytometryHumansImmunologic MemoryImmunophenotypingLupus Erythematosus, SystemicLymphocyte CountReceptors, ImmunologicReceptors, Interleukin-7Signaling Lymphocytic Activation Molecule FamilyConceptsEffector memoryFrequency of ILT cellsHealthy individualsHuman effector memoryTarget cellsSystemic lupus erythematosusPathogenesis of lupusSLE patientsMemory CD8Lupus erythematosusNK cellsCytotoxic functionPeripheral bloodDisease manifestationsPatientsCD48 antigenCytotoxic moleculesFlow cytometrySLECell populationsPotential roleLupusILCellular characteristics
1994
Pattern of anti-small nuclear ribonucleoprotein antibodies in MRL/Mp-lpr/lpr mice suggests that the intact U1 snRNP particle is their autoimmunogenic target.
Fatenejad S, Brooks W, Schwartz A, Craft J. Pattern of anti-small nuclear ribonucleoprotein antibodies in MRL/Mp-lpr/lpr mice suggests that the intact U1 snRNP particle is their autoimmunogenic target. The Journal Of Immunology 1994, 152: 5523-31. PMID: 7514640, DOI: 10.4049/jimmunol.152.11.5523.Peer-Reviewed Original ResearchConceptsMRL/lpr miceMRL/Mp-lpr/lpr miceLpr miceAnti-Sm AbsHuman SLEAnti-Sm responseRibonucleoprotein antibodiesNormal miceImmune responseMiceSLEEarly AbsSimilar epitopesD proteinsSerumHuman serumEpitopesU1 snRNP particleFrequent responsePrevious findingsAbResponseSnRNP particlesHumansPrevious observations
1993
Autoantigenic epitopes of the B and D polypeptides of the U1 snRNP. Analysis of domains recognized by the Y12 monoclonal anti-Sm antibody and by patient sera.
Hirakata M, Craft J, Hardin JA. Autoantigenic epitopes of the B and D polypeptides of the U1 snRNP. Analysis of domains recognized by the Y12 monoclonal anti-Sm antibody and by patient sera. The Journal Of Immunology 1993, 150: 3592-601. PMID: 7682245, DOI: 10.4049/jimmunol.150.8.3592.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibodies, MonoclonalAutoantigensBinding Sites, AntibodyEnzyme-Linked Immunosorbent AssayEpitopesHumansImmune SeraLupus Erythematosus, SystemicMiceMolecular Sequence DataProtein ConformationRibonucleoprotein, U1 Small NuclearRibonucleoproteins, Small NuclearSnRNP Core ProteinsConceptsAnti-Sm antibodiesMonoclonal anti-Sm antibodyPatient seraCross-reactive epitopesAutoantigenic epitopesAnti-Sm seraPolypeptide BD polypeptideAnti-Sm patient seraSerumSpecific markersSm small nuclear ribonucleoproteinsEpitopesEnd deletionsAntibodiesImmunoreactive sitesCorresponding synthetic peptideB'/BMAbsDeletion studiesPresent studyLittle amino acid sequence homologySynthetic peptidesAmino acid sequence homologySLE