2008
Autoantibodies against cyclophilin in systemic lupus erythematosus and Lyme disease
KRATZ A, HARDING MW, CRAFT J, MACKWORTH-YOUNG C, HANDSCHUMACHER RE. Autoantibodies against cyclophilin in systemic lupus erythematosus and Lyme disease. Clinical & Experimental Immunology 2008, 90: 422-427. PMID: 1458678, PMCID: PMC1554566, DOI: 10.1111/j.1365-2249.1992.tb05862.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAmino Acid IsomerasesAntibodies, Anti-IdiotypicAntibodies, MonoclonalAntibody SpecificityAutoantibodiesCarrier ProteinsChildEnzyme-Linked Immunosorbent AssayFamily HealthFemaleHumansImmunoglobulin GImmunoglobulin IdiotypesImmunoglobulin MLupus Erythematosus, SystemicLyme DiseaseMaleMiddle AgedPeptidylprolyl IsomeraseProtein DenaturationConceptsSystemic lupus erythematosusLupus erythematosusFirst-degree relativesLyme disease patientsMonoclonal IgM antibodyLupus patientsIgM antibodiesDisease patientsLepromatous leprosyImmune systemPatientsWestern blotLyme diseaseAntibodiesErythematosusAutoantibodiesHypergammaglobulinaemiaCyclophilinCyclosporinLeprosyDiseaseSerum
1996
Anti-U5 Small Nuclear Ribonucleoprotein (snRNP) Antibodies: A Rare Anti-U snRNP Specificity
Okano Y, Targoff I, Oddis C, Fujii T, Kuwana M, Tsuzaka K, Hirakata M, Mimori T, Craft J, Medsger T. Anti-U5 Small Nuclear Ribonucleoprotein (snRNP) Antibodies: A Rare Anti-U snRNP Specificity. Clinical Immunology 1996, 81: 41-47. PMID: 8808640, DOI: 10.1006/clin.1996.0155.Peer-Reviewed Original ResearchAutoantibodies to glycyl–transfer RNA synthetase in myositis. Association with dermatomyositis and immunologic heterogeneity
Hirakata M, Suwa A, Takeda Y, Matsuoka Y, Irimajiri S, Targoff I, Hardin J, Craft J. Autoantibodies to glycyl–transfer RNA synthetase in myositis. Association with dermatomyositis and immunologic heterogeneity. Arthritis & Rheumatism 1996, 39: 146-151. PMID: 8546723, DOI: 10.1002/art.1780390119.Peer-Reviewed Original ResearchConceptsTRNA synthetase antibodiesImmunologic heterogeneitySynthetase antibodiesTransfer RNA synthetase antibodiesPolymyositis/dermatomyositisInterstitial lung diseaseIdentification of antibodiesRheumatic diseasesLung diseaseClinical significanceEpitope specificityPatientsAutoantibodiesImmunoblotting findingsSerumAntibodiesDiseaseDermatomyositisMyositisRNA synthetaseImmunoprecipitation assaysAssociationGlycyl-tRNA synthetaseSpecificityFindings
1994
Pattern of anti-small nuclear ribonucleoprotein antibodies in MRL/Mp-lpr/lpr mice suggests that the intact U1 snRNP particle is their autoimmunogenic target.
Fatenejad S, Brooks W, Schwartz A, Craft J. Pattern of anti-small nuclear ribonucleoprotein antibodies in MRL/Mp-lpr/lpr mice suggests that the intact U1 snRNP particle is their autoimmunogenic target. The Journal Of Immunology 1994, 152: 5523-31. PMID: 7514640, DOI: 10.4049/jimmunol.152.11.5523.Peer-Reviewed Original ResearchConceptsMRL/lpr miceMRL/Mp-lpr/lpr miceLpr miceAnti-Sm AbsHuman SLEAnti-Sm responseRibonucleoprotein antibodiesNormal miceImmune responseMiceSLEEarly AbsSimilar epitopesD proteinsSerumHuman serumEpitopesU1 snRNP particleFrequent responsePrevious findingsAbResponseSnRNP particlesHumansPrevious observations
1993
Identification of autoantibodies to RNA polymerase II. Occurrence in systemic sclerosis and association with autoantibodies to RNA polymerases I and III.
Hirakata M, Okano Y, Pati U, Suwa A, Medsger TA, Hardin JA, Craft J. Identification of autoantibodies to RNA polymerase II. Occurrence in systemic sclerosis and association with autoantibodies to RNA polymerases I and III. Journal Of Clinical Investigation 1993, 91: 2665-2672. PMID: 8390487, PMCID: PMC443330, DOI: 10.1172/jci116505.Peer-Reviewed Original ResearchConceptsSystemic sclerosisII antibodiesAnti-RNA polymerase II antibodiesLimited cutaneous diseaseConnective tissue diseaseIdentification of autoantibodiesSera of patientsIndirect immunofluorescence studiesHuman serumTissue diseaseCutaneous diseaseNormal controlsAutoantibodiesSclerosisPatientsHuman antibodiesRNA polymerase IIClinical perspectiveMonoclonal antibodiesAntibodiesSerumRNA polymerase IImmunofluorescence studiesImmunodepletion studiesFurther studiesAutoantigenic epitopes of the B and D polypeptides of the U1 snRNP. Analysis of domains recognized by the Y12 monoclonal anti-Sm antibody and by patient sera.
Hirakata M, Craft J, Hardin JA. Autoantigenic epitopes of the B and D polypeptides of the U1 snRNP. Analysis of domains recognized by the Y12 monoclonal anti-Sm antibody and by patient sera. The Journal Of Immunology 1993, 150: 3592-601. PMID: 7682245, DOI: 10.4049/jimmunol.150.8.3592.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibodies, MonoclonalAutoantigensBinding Sites, AntibodyEnzyme-Linked Immunosorbent AssayEpitopesHumansImmune SeraLupus Erythematosus, SystemicMiceMolecular Sequence DataProtein ConformationRibonucleoprotein, U1 Small NuclearRibonucleoproteins, Small NuclearSnRNP Core ProteinsConceptsAnti-Sm antibodiesMonoclonal anti-Sm antibodyPatient seraCross-reactive epitopesAutoantigenic epitopesAnti-Sm seraPolypeptide BD polypeptideAnti-Sm patient seraSerumSpecific markersSm small nuclear ribonucleoproteinsEpitopesEnd deletionsAntibodiesImmunoreactive sitesCorresponding synthetic peptideB'/BMAbsDeletion studiesPresent studyLittle amino acid sequence homologySynthetic peptidesAmino acid sequence homologySLE
1991
PBC 95K, a 95‐kilodalton nuclear autoantigen in primary biliary cirrhosis
Evans J, Reuben A, Craft J. PBC 95K, a 95‐kilodalton nuclear autoantigen in primary biliary cirrhosis. Arthritis & Rheumatism 1991, 34: 731-736. PMID: 2053918, DOI: 10.1002/art.1780340614.Peer-Reviewed Original ResearchConceptsPrimary biliary cirrhosisAntinuclear antibodiesBiliary cirrhosisANA-positive samplesConnective tissue diseaseSera of patientsANA-positive seraHEp-2 cellsPBC patientsLiver diseaseTissue diseaseNuclear dotsPatientsIndirect immunofluorescenceNuclear autoantigensStaining patternAffinity-purified antibodiesSerumAntibodiesCirrhosisDiseaseAutoantigensTiters
1989
Biochemical and immunological heterogeneity of the Ro ribonucleoprotein particles. Analysis with sera specific for the RohY5 particle.
Boire G, Craft J. Biochemical and immunological heterogeneity of the Ro ribonucleoprotein particles. Analysis with sera specific for the RohY5 particle. Journal Of Clinical Investigation 1989, 84: 270-279. PMID: 2472427, PMCID: PMC303979, DOI: 10.1172/jci114150.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusRelated diseasesRo particleAnti-Ro autoantibodiesAnti-Ro seraCell fractionRo antibodiesSystemic lupusLupus erythematosusPatient seraImmunological heterogeneityAutoantibodiesSpecific serumRo responseNonhuman cell linesSerumAntigenic determinantsAntibodiesCell linesInhibition assaysDiseaseEpitopesCompetitive inhibitionSuch extractsErythematosus
1988
Antibodies in human serum that precipitate ribonuclease P.
Gold HA, Craft J, Hardin JA, Bartkiewicz M, Altman S. Antibodies in human serum that precipitate ribonuclease P. Proceedings Of The National Academy Of Sciences Of The United States Of America 1988, 85: 5483-5487. PMID: 2456570, PMCID: PMC281781, DOI: 10.1073/pnas.85.15.5483.Peer-Reviewed Original ResearchMurine graft vs host disease. A model for study of mechanisms that generate autoantibodies to ribonucleoproteins.
Gelpi C, Rodriguez-Sanchez JL, Martinez MA, Craft J, Hardin JA. Murine graft vs host disease. A model for study of mechanisms that generate autoantibodies to ribonucleoproteins. The Journal Of Immunology 1988, 140: 4160-6. PMID: 3372998, DOI: 10.4049/jimmunol.140.12.4160.Peer-Reviewed Original ResearchConceptsHost diseaseChronic graftAutoimmune responseMixed connective tissue diseaseInduction of graftConnective tissue diseaseHuman rheumatic diseasesAnti-U1 RNPAntinuclear antibodiesMurine graftRheumatic diseasesRNP autoantibodiesTissue diseaseAutoantigenic epitopesLymphoid cellsJ strainAdditional seraGraftDiseaseMiceSerumAntibodiesAutoantibodiesMaximal levelsHuman serumThe U2 small nuclear ribonucleoprotein particle as an autoantigen. Analysis with sera from patients with overlap syndromes.
Craft J, Mimori T, Olsen TL, Hardin JA. The U2 small nuclear ribonucleoprotein particle as an autoantigen. Analysis with sera from patients with overlap syndromes. Journal Of Clinical Investigation 1988, 81: 1716-1724. PMID: 2968364, PMCID: PMC442616, DOI: 10.1172/jci113511.Peer-Reviewed Original Research
1987
Autoantigenic histone epitopes: a comparison between procainamide‐ and hydralazine‐induced lupus
Craft J, Radding J, Harding M, Bernstein R, Hardin J. Autoantigenic histone epitopes: a comparison between procainamide‐ and hydralazine‐induced lupus. Arthritis & Rheumatism 1987, 30: 689-694. PMID: 2440452, DOI: 10.1002/art.1780300612.Peer-Reviewed Original ResearchConceptsHydralazine-induced lupusSpontaneous systemic lupus erythematosusDrug-induced lupusSystemic lupus erythematosusAbility of serumProcainamide-induced lupusHistone epitopesLupus erythematosusAntihistone antibodiesLupusTechnique of immunoblottingPatientsIndividual histonesSerumEpitopesHistone fragmentsDifferent mechanismsErythematosusProcainamideAntibodies