2003
γδ T Cells Provide an Early Source of Interferon γ in Tumor Immunity
Gao Y, Yang W, Pan M, Scully E, Girardi M, Augenlicht LH, Craft J, Yin Z. γδ T Cells Provide an Early Source of Interferon γ in Tumor Immunity. Journal Of Experimental Medicine 2003, 198: 433-442. PMID: 12900519, PMCID: PMC2194096, DOI: 10.1084/jem.20030584.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsImmunity, CellularInterferon-gammaInterleukin-12Lymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutNeoplasm TransplantationNeoplasms, ExperimentalReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocyte SubsetsTransplantation ChimeraTumor Cells, CulturedConceptsGammadelta T cellsAlphabeta T cellsT cellsTumor immunityIFN-gammaHigh incidenceGammadelta T cell-deficient miceImpaired IFN-gamma productionT cell-deficient miceTumor developmentCell-deficient miceBone marrow chimerasΓδ T cellsIFN-gamma productionSite of tumorT cell repertoireWild-type miceChemical carcinogen methylcholanthreneMelanoma cell line B16B16 melanoma cellsTumor lysateCarcinogen methylcholanthreneTumor immunosurveillanceInterferon γSuch mice
1996
A tumor-suppressor function for Fas (CD95) revealed in T cell-deficient mice.
Peng SL, Robert ME, Hayday AC, Craft J. A tumor-suppressor function for Fas (CD95) revealed in T cell-deficient mice. Journal Of Experimental Medicine 1996, 184: 1149-1154. PMID: 9064331, PMCID: PMC2192794, DOI: 10.1084/jem.184.3.1149.Peer-Reviewed Original ResearchConceptsAlpha beta T cellsGamma delta T cellsBeta T cellsTumor suppressorDelta T cellsT cellsTumor suppressor functionCentral regulatory moleculeLethal B-cell lymphomaT cell-deficient miceB cell dysregulationCell-deficient miceRegulatory moleculesDevelopment of lymphomaB-cell lymphomaTumor regulationFas functionHematopoietic cellsFunctional FasRheumatoid factorCell dysregulationMalignant tumorsCell lymphomaIdentifies rolesImmunoglobulin M