2015
Circulating Follicular Helper–Like T Cells in Systemic Lupus Erythematosus: Association With Disease Activity
Choi J, Ho J, Pasoto SG, Bunin V, Kim ST, Carrasco S, Borba EF, Gonçalves CR, Costa PR, Kallas EG, Bonfa E, Craft J. Circulating Follicular Helper–Like T Cells in Systemic Lupus Erythematosus: Association With Disease Activity. Arthritis & Rheumatology 2015, 67: 988-999. PMID: 25581113, PMCID: PMC4450082, DOI: 10.1002/art.39020.Peer-Reviewed Original ResearchConceptsTfh-like cellsSLE Disease Activity IndexSystemic lupus erythematosusInducible T-cell costimulatorPD-1 expressionDisease activityT cellsBehçet's diseaseSLE patientsLupus erythematosusBlood samplesT cell-B cell collaborationCentral memory T cellsExpression of CXCR5Disease activity indexGerminal center activityMemory T cellsDeath 1 proteinFollicular helper TT-cell costimulatorActive diseaseAntibody positivityDisease durationFollicular helperIL-21Local Triggering of the ICOS Coreceptor by CD11c+ Myeloid Cells Drives Organ Inflammation in Lupus
Teichmann LL, Cullen JL, Kashgarian M, Dong C, Craft J, Shlomchik MJ. Local Triggering of the ICOS Coreceptor by CD11c+ Myeloid Cells Drives Organ Inflammation in Lupus. Immunity 2015, 42: 552-565. PMID: 25786178, PMCID: PMC4456685, DOI: 10.1016/j.immuni.2015.02.015.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisAutoantibodiesCD11c AntigenCell DifferentiationFemaleGene Expression RegulationHumansInducible T-Cell Co-Stimulator LigandInducible T-Cell Co-Stimulator ProteinKidneyLungLupus NephritisMice, TransgenicPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionT-Lymphocytes, Helper-InducerConceptsInducible T-cell costimulatorOrgan inflammationICOS ligandFollicular helper cell differentiationLupus-prone MRLT-cell costimulatorHelper cell differentiationLupus pathologyLung inflammationAutoantibody formationAutoantibody productionMurine lupusInflamed organsLymphoid tissueT cellsB cellsPathogenic relevanceInflammationLupusPI3K-AktSelective ablationCell differentiationNonredundant rolePotent promoterCells
2012
Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells
Kinnunen T, Chamberlain N, Morbach H, Choi J, Kim S, Craft J, Mayer L, Cancrini C, Passerini L, Bacchetta R, Ochs HD, Torgerson TR, Meffre E. Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells. Blood 2012, 121: 1595-1603. PMID: 23223361, PMCID: PMC3587322, DOI: 10.1182/blood-2012-09-457465.Peer-Reviewed Original ResearchConceptsB cell tolerancePeripheral B cell toleranceIPEX patientsRegulatory T cellsAutoreactive B cellsNaive B cellsB cellsT cellsTreg functionAutoreactive mature naive B cellsHuman B cell toleranceForkhead box protein 3 geneHuman regulatory T cellsMature naive B cellsTreg-like cellsCentral B cell toleranceSevere autoimmune disordersT-cell costimulatorTransitional B cellsRegulation of CD40LReactivity of antibodiesDefective Treg functionSingle B cellsPD-1Autoimmune disorders