2011
The characterization of thymus-derived natural Th17 cells and their response to inflammation. (108.9)
Nowyhed H, Bertino S, Tao J, Marks B, Choi J, Craft J. The characterization of thymus-derived natural Th17 cells and their response to inflammation. (108.9). The Journal Of Immunology 2011, 186: 108.9-108.9. DOI: 10.4049/jimmunol.186.supp.108.9.Peer-Reviewed Original ResearchNatural Th17 cellsNTh17 cellsTh17 cellsNatural T Regulatory CellsCD4 T helper cellsIL-22 secretionT regulatory (Treg) cellsCertain autoimmune conditionsFunction of Th1T helper cellsIL-17AAutoimmune conditionsRegulatory cellsIL-22Neutrophil recruitmentHelper cellsIL-1βSelf antigensIL-1R1Th1 cellsNTreg cellsIL-17RCTh2 cellsTissue destructionEffector lineagesCharacterization of different subsets of human follicular helper T (TFH) cells (152.9)
Choi J, Kim S, Lainez B, Craft J. Characterization of different subsets of human follicular helper T (TFH) cells (152.9). The Journal Of Immunology 2011, 186: 152.9-152.9. DOI: 10.4049/jimmunol.186.supp.152.9.Peer-Reviewed Original ResearchFollicular helper T cellsB cell folliclesHelper T cellsTfh cellsT cellsIL-21P-selectin glycoprotein ligand-1IL-4Germinal centersB cellsTonsillar Tfh cellsIL-17 secretionExpression of CD127B cell helpAntigen-specific antibodiesGC B cellsTh17 cellsTfh subsetsPD-1Effector subsetsCell helpTherapeutic targetBCL-6RORC expressionHuman tonsils
2010
Thymic self-reactivity selects for natural Th17 cells which can be distinguished by unique markers (143.49)
Nowyhed H, Marks B, Choi J, Craft J. Thymic self-reactivity selects for natural Th17 cells which can be distinguished by unique markers (143.49). The Journal Of Immunology 2010, 184: 143.49-143.49. DOI: 10.4049/jimmunol.184.supp.143.49.Peer-Reviewed Original ResearchNatural Th17 cellsNTh17 cellsTh17 cellsIL-17RCIL-17RENatural T Regulatory CellsCD4 T helper cellsT regulatory (Treg) cellsIL-22 secretionCertain autoimmune conditionsFunction of Th1T helper cellsAutoimmune conditionsIL-17ARegulatory cellsNeutrophil recruitmentIL-22Self antigensHelper cellsTh1 cellsLevel of secretionNTreg cellsTh2 cellsTissue destructionEffector lineagesDysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus
Shah K, Lee WW, Lee SH, Kim SH, Kang SW, Craft J, Kang I. Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus. Arthritis Research & Therapy 2010, 12: r53. PMID: 20334681, PMCID: PMC2888202, DOI: 10.1186/ar2964.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusSLE Disease Activity Index (SLEDAI) scorePeripheral blood mononuclear cellsTh17-polarizing cytokinesTh1 cell responsesDisease activityT cellsHealthy subjectsIL-17Th1 cellsCell responsesPhorbol myristate acetateTh17 cellsLupus erythematosusIL-6Plasma levelsDisease activity index scoreBalance of CD4Balance of Th17Expression of Th17Th17 cell responseActivity index scoreFrequency of CD4Chemokine receptor CCR4Blood mononuclear cells