2015
IL-21 Promotes Pulmonary Fibrosis through the Induction of Profibrotic CD8+ T Cells
Brodeur TY, Robidoux TE, Weinstein JS, Craft J, Swain SL, Marshak-Rothstein A. IL-21 Promotes Pulmonary Fibrosis through the Induction of Profibrotic CD8+ T Cells. The Journal Of Immunology 2015, 195: 5251-5260. PMID: 26519529, PMCID: PMC4655158, DOI: 10.4049/jimmunol.1500777.Peer-Reviewed Original Research
2013
CD301b+ Dermal Dendritic Cells Drive T Helper 2 Cell-Mediated Immunity
Kumamoto Y, Linehan M, Weinstein JS, Laidlaw BJ, Craft JE, Iwasaki A. CD301b+ Dermal Dendritic Cells Drive T Helper 2 Cell-Mediated Immunity. Immunity 2013, 39: 733-743. PMID: 24076051, PMCID: PMC3819035, DOI: 10.1016/j.immuni.2013.08.029.Peer-Reviewed Original ResearchConceptsDermal dendritic cellsDendritic cellsDermal DCsTh2 cellsT cellsT helper 2 cellsT helper responsesInterleukin-4 productionExpression of CD69Th2 cell developmentDC depletionLymph nodesTh2 immunityHelper responsesSubcutaneous immunizationNippostrongylus brasiliensisKey mediatorTransient depletionCell developmentImmunityOvalbuminDepletion approachCellsParticular subsetCD301b
2011
The characterization of thymus-derived natural Th17 cells and their response to inflammation. (108.9)
Nowyhed H, Bertino S, Tao J, Marks B, Choi J, Craft J. The characterization of thymus-derived natural Th17 cells and their response to inflammation. (108.9). The Journal Of Immunology 2011, 186: 108.9-108.9. DOI: 10.4049/jimmunol.186.supp.108.9.Peer-Reviewed Original ResearchNatural Th17 cellsNTh17 cellsTh17 cellsNatural T Regulatory CellsCD4 T helper cellsIL-22 secretionT regulatory (Treg) cellsCertain autoimmune conditionsFunction of Th1T helper cellsIL-17AAutoimmune conditionsRegulatory cellsIL-22Neutrophil recruitmentHelper cellsIL-1βSelf antigensIL-1R1Th1 cellsNTreg cellsIL-17RCTh2 cellsTissue destructionEffector lineages
2010
Thymic self-reactivity selects for natural Th17 cells which can be distinguished by unique markers (143.49)
Nowyhed H, Marks B, Choi J, Craft J. Thymic self-reactivity selects for natural Th17 cells which can be distinguished by unique markers (143.49). The Journal Of Immunology 2010, 184: 143.49-143.49. DOI: 10.4049/jimmunol.184.supp.143.49.Peer-Reviewed Original ResearchNatural Th17 cellsNTh17 cellsTh17 cellsIL-17RCIL-17RENatural T Regulatory CellsCD4 T helper cellsT regulatory (Treg) cellsIL-22 secretionCertain autoimmune conditionsFunction of Th1T helper cellsAutoimmune conditionsIL-17ARegulatory cellsNeutrophil recruitmentIL-22Self antigensHelper cellsTh1 cellsLevel of secretionNTreg cellsTh2 cellsTissue destructionEffector lineages
2000
Dominance of IL-12 Over IL-4 in γδ T Cell Differentiation Leads to Default Production of IFN-γ: Failure to Down-Regulate IL-12 Receptor β2-Chain Expression
Yin Z, Zhang D, Welte T, Bahtiyar G, Jung S, Liu L, Fu X, Ray A, Craft J. Dominance of IL-12 Over IL-4 in γδ T Cell Differentiation Leads to Default Production of IFN-γ: Failure to Down-Regulate IL-12 Receptor β2-Chain Expression. The Journal Of Immunology 2000, 164: 3056-3064. PMID: 10706694, DOI: 10.4049/jimmunol.164.6.3056.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCells, CulturedCytokinesDNA-Binding ProteinsDown-RegulationGATA3 Transcription FactorInterferon-gammaInterleukin-12Interleukin-4Lymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C57BLReceptors, Antigen, T-Cell, gamma-deltaReceptors, InterleukinReceptors, Interleukin-12Signal TransductionSTAT3 Transcription FactorSTAT4 Transcription FactorTh1 CellsTh2 CellsT-Lymphocyte SubsetsTrans-ActivatorsConceptsGamma delta T cellsDelta T cellsT cellsIFN-gammaIL-12IL-4Murine gamma delta T cellsSplenic gamma delta T cellsAlpha beta T cellsIFN-gamma-producing cellsΓδ T-cell differentiationIL-4-secreting cellsBeta T cellsTh2-like cytokinesIL-12 receptorTranscription factor GATA-3T cell differentiationTumor immunityTh1 cellsTh2 cellsSuch cytokinesFinding independentReceptor betaGATA-3Intracellular pathogens