2023
Bulk and single-nucleus RNA sequencing highlight immune pathways induced in individuals during an Ixodes scapularis tick bite
Tang X, Lynn G, Cui Y, Cerny J, Arora G, Tomayko M, Craft J, Fikrig E. Bulk and single-nucleus RNA sequencing highlight immune pathways induced in individuals during an Ixodes scapularis tick bite. Infection And Immunity 2023, 91: e00282-23. PMID: 37846980, PMCID: PMC10652856, DOI: 10.1128/iai.00282-23.Peer-Reviewed Original ResearchConceptsRNA sequencingSingle-nucleus RNA sequencingBulk RNA sequencingInterleukin-17 signalingPlatelet activation pathwaysLaboratory guinea pigsSnRNA-seqHippo signalingIndividual genesPeripheral bloodTick biteAdaptive immunityAnti-tick vaccinesGuidance pathwayImmune pathwaysNew biomarkersHost responseGuinea pigsHematophagous arthropodsHost defenseCell adhesionTick attachmentNovel insightsTick feedingPhysiological consequences
1992
Prevention of Lyme Disease after Tick Bites
Magid D, Schwartz B, Craft J, Schwartz J. Prevention of Lyme Disease after Tick Bites. New England Journal Of Medicine 1992, 327: 534-541. PMID: 1298217, DOI: 10.1056/nejm199208203270806.Peer-Reviewed Original ResearchConceptsTick biteProbability of infectionLyme diseaseOnly patientsEmpirical therapyErythema migransEmpirical treatmentBurgdorferi infectionAdditional minor complicationsMost major complicationsWeeks of doxycyclinePositive serologic testsDisease one monthEndemic Lyme diseaseBorrelia burgdorferi infectionB. burgdorferi infectionAdverse eventsMinor complicationsMost complicationsMajor complicationsEarly treatmentSerologic testsPatientsComplicationsInfection