2010
Naturally Activated Vγ4 γδ T Cells Play a Protective Role in Tumor Immunity through Expression of Eomesodermin
He W, Hao J, Dong S, Gao Y, Tao J, Chi H, Flavell R, O’Brien R, Born WK, Craft J, Han J, Wang P, Zhao L, Wu J, Yin Z. Naturally Activated Vγ4 γδ T Cells Play a Protective Role in Tumor Immunity through Expression of Eomesodermin. The Journal Of Immunology 2010, 185: 126-133. PMID: 20525896, PMCID: PMC3813958, DOI: 10.4049/jimmunol.0903767.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCell Line, TumorCoculture TechniquesCytotoxicity, ImmunologicHyaluronan ReceptorsInterferon-gammaLymphocyte ActivationMelanoma, ExperimentalMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicPerforinReceptors, Antigen, T-Cell, gamma-deltaT-Box Domain ProteinsT-Lymphocyte SubsetsUp-RegulationConceptsGammadelta T cellsAntitumor immune responseT cellsImmune responseIFN-gammaTumor immunityProtective roleVγ4 γδ T cellsTumor immune surveillanceΓδ T cellsIFN-gamma secretionTumor immune therapyMore IFN-gammaGreater cytolytic activityExpression of EomesoderminAntitumor responseImmune therapyImmune surveillanceCytolytic activityEffector functionsPrincipal subsetsVgamma4Vgamma1Precise rolePerforin
2003
γδ T Cells Provide an Early Source of Interferon γ in Tumor Immunity
Gao Y, Yang W, Pan M, Scully E, Girardi M, Augenlicht LH, Craft J, Yin Z. γδ T Cells Provide an Early Source of Interferon γ in Tumor Immunity. Journal Of Experimental Medicine 2003, 198: 433-442. PMID: 12900519, PMCID: PMC2194096, DOI: 10.1084/jem.20030584.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsImmunity, CellularInterferon-gammaInterleukin-12Lymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutNeoplasm TransplantationNeoplasms, ExperimentalReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocyte SubsetsTransplantation ChimeraTumor Cells, CulturedConceptsGammadelta T cellsAlphabeta T cellsT cellsTumor immunityIFN-gammaHigh incidenceGammadelta T cell-deficient miceImpaired IFN-gamma productionT cell-deficient miceTumor developmentCell-deficient miceBone marrow chimerasΓδ T cellsIFN-gamma productionSite of tumorT cell repertoireWild-type miceChemical carcinogen methylcholanthreneMelanoma cell line B16B16 melanoma cellsTumor lysateCarcinogen methylcholanthreneTumor immunosurveillanceInterferon γSuch mice
2000
Dominance of IL-12 Over IL-4 in γδ T Cell Differentiation Leads to Default Production of IFN-γ: Failure to Down-Regulate IL-12 Receptor β2-Chain Expression
Yin Z, Zhang D, Welte T, Bahtiyar G, Jung S, Liu L, Fu X, Ray A, Craft J. Dominance of IL-12 Over IL-4 in γδ T Cell Differentiation Leads to Default Production of IFN-γ: Failure to Down-Regulate IL-12 Receptor β2-Chain Expression. The Journal Of Immunology 2000, 164: 3056-3064. PMID: 10706694, DOI: 10.4049/jimmunol.164.6.3056.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCells, CulturedCytokinesDNA-Binding ProteinsDown-RegulationGATA3 Transcription FactorInterferon-gammaInterleukin-12Interleukin-4Lymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C57BLReceptors, Antigen, T-Cell, gamma-deltaReceptors, InterleukinReceptors, Interleukin-12Signal TransductionSTAT3 Transcription FactorSTAT4 Transcription FactorTh1 CellsTh2 CellsT-Lymphocyte SubsetsTrans-ActivatorsConceptsGamma delta T cellsDelta T cellsT cellsIFN-gammaIL-12IL-4Murine gamma delta T cellsSplenic gamma delta T cellsAlpha beta T cellsIFN-gamma-producing cellsΓδ T-cell differentiationIL-4-secreting cellsBeta T cellsTh2-like cytokinesIL-12 receptorTranscription factor GATA-3T cell differentiationTumor immunityTh1 cellsTh2 cellsSuch cytokinesFinding independentReceptor betaGATA-3Intracellular pathogens