2003
Age-dependent Requirement for γδ T Cells in the Primary but Not Secondary Protective Immune Response against an Intestinal Parasite
Ramsburg E, Tigelaar R, Craft J, Hayday A. Age-dependent Requirement for γδ T Cells in the Primary but Not Secondary Protective Immune Response against an Intestinal Parasite. Journal Of Experimental Medicine 2003, 198: 1403-1414. PMID: 14597739, PMCID: PMC2194243, DOI: 10.1084/jem.20030050.Peer-Reviewed Original ResearchConceptsAlphabeta T cellsGammadelta cellsT cellsYoung miceImmune responseAdult miceIntestinal parasitesPathogen-specific immunityΓδ T cellsCellular immune responsesProtective immune responseT cell receptorWk of ageAdoptive transferDevelopment of resistanceImmune protectionNewborn recipientsEimeria vermiformisAge-dependent requirementsCell receptorMiceE. vermiformisLymphoid progenitorsInfectionYoung hosts
2000
Conditional up-regulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies
Nagaraju K, Raben N, Loeffler L, Parker T, Rochon P, Lee E, Danning C, Wada R, Thompson C, Bahtiyar G, Craft J, van Huijsduijnen R, Plotz P. Conditional up-regulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 9209-9214. PMID: 10922072, PMCID: PMC16847, DOI: 10.1073/pnas.97.16.9209.Peer-Reviewed Original ResearchConceptsMHC class IMyositis-specific autoantibodiesClass IAutoimmune diseasesSkeletal muscleHuman inflammatory myopathiesHuman myositisInflammatory myopathiesAutoimmune myositisImmunological featuresSpontaneous human diseaseYoung miceAutoantibodiesMuscle cellsNonspecific eventsDiseaseMiceMyositisMuscleCommon specificityHuman diseasesSpecific patternsSpecificityStimuliMyopathy