2019
Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function
Bailis W, Shyer JA, Zhao J, Canaveras JCG, Al Khazal FJ, Qu R, Steach HR, Bielecki P, Khan O, Jackson R, Kluger Y, Maher LJ, Rabinowitz J, Craft J, Flavell RA. Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function. Nature 2019, 571: 403-407. PMID: 31217581, PMCID: PMC6939459, DOI: 10.1038/s41586-019-1311-3.Peer-Reviewed Original ResearchConceptsMitochondrial citrate exportTerminal effector functionsMalate-aspartate shuttleCitrate exportHistone acetylationCell differentiationComplex ICellular biochemical compositionT cell differentiationSuccinate dehydrogenaseT cell activationExpression of genesElectron transport chainTricarboxylic acid cycleT cell receptor ligationAnabolic programTranscriptional remodellingTranscriptional programmingEpigenetic remodellingSignal transductionCell activationMetabolic reprogrammingCell statesDistinct modesEffector functions
2007
Epigenetic and Transcriptional Programs Lead to Default IFN-γ Production by γδ T Cells
Chen L, He W, Kim ST, Tao J, Gao Y, Chi H, Intlekofer AM, Harvey B, Reiner SL, Yin Z, Flavell RA, Craft J. Epigenetic and Transcriptional Programs Lead to Default IFN-γ Production by γδ T Cells. The Journal Of Immunology 2007, 178: 2730-2736. PMID: 17312115, DOI: 10.4049/jimmunol.178.5.2730.Peer-Reviewed Original Research
1993
Identification of autoantibodies to RNA polymerase II. Occurrence in systemic sclerosis and association with autoantibodies to RNA polymerases I and III.
Hirakata M, Okano Y, Pati U, Suwa A, Medsger TA, Hardin JA, Craft J. Identification of autoantibodies to RNA polymerase II. Occurrence in systemic sclerosis and association with autoantibodies to RNA polymerases I and III. Journal Of Clinical Investigation 1993, 91: 2665-2672. PMID: 8390487, PMCID: PMC443330, DOI: 10.1172/jci116505.Peer-Reviewed Original ResearchConceptsSystemic sclerosisII antibodiesAnti-RNA polymerase II antibodiesLimited cutaneous diseaseConnective tissue diseaseIdentification of autoantibodiesSera of patientsIndirect immunofluorescence studiesHuman serumTissue diseaseCutaneous diseaseNormal controlsAutoantibodiesSclerosisPatientsHuman antibodiesRNA polymerase IIClinical perspectiveMonoclonal antibodiesAntibodiesSerumRNA polymerase IImmunofluorescence studiesImmunodepletion studiesFurther studies