2003
STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: A critical role of STAT3 in innate immunity
Welte T, Zhang SS, Wang T, Zhang Z, Hesslein DG, Yin Z, Kano A, Iwamoto Y, Li E, Craft JE, Bothwell AL, Fikrig E, Koni PA, Flavell RA, Fu XY. STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: A critical role of STAT3 in innate immunity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 1879-1884. PMID: 12571365, PMCID: PMC149927, DOI: 10.1073/pnas.0237137100.Peer-Reviewed Original ResearchConceptsDeletion of Stat3STAT3 deletionInnate immune responseKey transcriptional mediatorNormal embryonic developmentCell-autonomous proliferationAbsence of STAT3Tissue-specific disruptionImmune responseInnate immunityCritical roleTumor necrosis factor alphaNF-kappa B activationTranscriptional mediatorsEmbryonic developmentBowel wall thickeningHematopoiesis resultsInflammatory cell infiltrationSignal transducerNecrosis factor alphaTranscription 3NAPDH oxidase activityBone marrow cellsMyeloid lineageSTAT3
2002
Transgenic Overexpression of Interleukin (IL)-10 in the Lung Causes Mucus Metaplasia, Tissue Inflammation, and Airway Remodeling via IL-13-dependent and -independent Pathways*
Lee CG, Homer RJ, Cohn L, Link H, Jung S, Craft JE, Graham BS, Johnson TR, Elias JA. Transgenic Overexpression of Interleukin (IL)-10 in the Lung Causes Mucus Metaplasia, Tissue Inflammation, and Airway Remodeling via IL-13-dependent and -independent Pathways*. Journal Of Biological Chemistry 2002, 277: 35466-35474. PMID: 12107190, DOI: 10.1074/jbc.m206395200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceChloride ChannelsCloning, MolecularDNA PrimersFluorescent Antibody TechniqueGene Expression RegulationIn Situ HybridizationInflammationInterleukin-10Interleukin-13LungMiceMice, TransgenicMolecular Sequence DataMucoproteinsMucous MembranePhenotypePolymerase Chain ReactionReceptors, Interleukin-4STAT6 Transcription FactorTrans-ActivatorsConceptsMucus metaplasiaIL-10Tissue inflammationIL-13Tumor necrosis factor productionIL-13/ILLipopolysaccharide-induced inflammationNecrosis factor productionAirway fibrosisNeutrophil accumulationAirway remodelingSubepithelial fibrosisGob-5Levels of mRNAMetaplasiaInflammationTransgenic miceFibrosisSTAT-6Effector propertiesTransgenic overexpressionFactor productionMiceInterleukinMultiple mechanismsT-Bet Expression and Failure of GATA-3 Cross-Regulation Lead to Default Production of IFN-γ by γδ T Cells
Yin Z, Chen C, Szabo SJ, Glimcher LH, Ray A, Craft J. T-Bet Expression and Failure of GATA-3 Cross-Regulation Lead to Default Production of IFN-γ by γδ T Cells. The Journal Of Immunology 2002, 168: 1566-1571. PMID: 11823483, DOI: 10.4049/jimmunol.168.4.1566.Peer-Reviewed Original ResearchAnimalsCells, CulturedDNA-Binding ProteinsFlow CytometryGATA3 Transcription FactorInterferon-gammaInterleukin-12Interleukin-4Lymphocyte ActivationMiceMice, Inbred C57BLMicroscopy, ConfocalReceptors, Antigen, T-Cell, gamma-deltaRNA, MessengerT-Box Domain ProteinsT-LymphocytesTrans-ActivatorsTranscription FactorsTranscriptional ActivationTransfection
2000
Dominance of IL-12 Over IL-4 in γδ T Cell Differentiation Leads to Default Production of IFN-γ: Failure to Down-Regulate IL-12 Receptor β2-Chain Expression
Yin Z, Zhang D, Welte T, Bahtiyar G, Jung S, Liu L, Fu X, Ray A, Craft J. Dominance of IL-12 Over IL-4 in γδ T Cell Differentiation Leads to Default Production of IFN-γ: Failure to Down-Regulate IL-12 Receptor β2-Chain Expression. The Journal Of Immunology 2000, 164: 3056-3064. PMID: 10706694, DOI: 10.4049/jimmunol.164.6.3056.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCells, CulturedCytokinesDNA-Binding ProteinsDown-RegulationGATA3 Transcription FactorInterferon-gammaInterleukin-12Interleukin-4Lymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C57BLReceptors, Antigen, T-Cell, gamma-deltaReceptors, InterleukinReceptors, Interleukin-12Signal TransductionSTAT3 Transcription FactorSTAT4 Transcription FactorTh1 CellsTh2 CellsT-Lymphocyte SubsetsTrans-ActivatorsConceptsGamma delta T cellsDelta T cellsT cellsIFN-gammaIL-12IL-4Murine gamma delta T cellsSplenic gamma delta T cellsAlpha beta T cellsIFN-gamma-producing cellsΓδ T-cell differentiationIL-4-secreting cellsBeta T cellsTh2-like cytokinesIL-12 receptorTranscription factor GATA-3T cell differentiationTumor immunityTh1 cellsTh2 cellsSuch cytokinesFinding independentReceptor betaGATA-3Intracellular pathogens