Protective antibodies in murine Lyme disease arise independently of CD40 ligand.
Fikrig E, Barthold SW, Chen M, Grewal IS, Craft J, Flavell RA. Protective antibodies in murine Lyme disease arise independently of CD40 ligand. The Journal Of Immunology 1996, 157: 1-3. PMID: 8683101, DOI: 10.4049/jimmunol.157.1.1.Peer-Reviewed Original ResearchConceptsCD40L-deficient miceCD40 ligand-deficient miceMurine Lyme diseaseRegression of arthritisTransfer of serumDependent immune responsesIgG2b AbsAcute arthritisControl miceProtective antibodiesIg class switchingCD40 ligandImmune responseImmunodeficient miceLyme borreliosisLyme diseaseMiceBorrelia burgdorferiB. burgdorferiClass switchingArthritisBurgdorferiAbInfectionDiseaseGerminal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells.
Wen L, Pao W, Wong FS, Peng Q, Craft J, Zheng B, Kelsoe G, Dianda L, Owen MJ, Hayday AC. Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells. Journal Of Experimental Medicine 1996, 183: 2271-2282. PMID: 8642336, PMCID: PMC2192585, DOI: 10.1084/jem.183.5.2271.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantibodiesClone CellsFlow CytometryGerminal CenterHumansImmunoglobulin Class SwitchingImmunoglobulin EImmunoglobulin GLupus Erythematosus, SystemicLymphocyte DepletionMiceMice, Inbred NODMice, Inbred StrainsMice, KnockoutMice, SCIDReceptors, Antigen, T-Cell, alpha-betaSpleenT-LymphocytesConceptsSystemic lupus erythematosusBeta T cellsAlpha/beta T cellsGamma/delta T cellsDelta T cellsT cell helpT cellsT cell receptorCell helpT cell-mediated conditionsHuman systemic lupus erythematosusSevere combined immunodeficient (SCID) miceDevelopment of autoantibodiesCombined Immunodeficient MiceT-cell immunodeficiencyClass-switched antibodiesB cell collaborationGerminal center formationLupus erythematosusAutoantibody productionLymphoid folliclesImmunoglobulin class switchingIgE synthesisAlpha/betaCell immunodeficiency