2002
The transmembrane form of TNF-α drives autoantibody production in the absence of CD154: studies using MRL/Mp-Faslpr mice
FUJII T, OKADA M, MIMORI T, CRAFT J. The transmembrane form of TNF-α drives autoantibody production in the absence of CD154: studies using MRL/Mp-Faslpr mice. Clinical & Experimental Immunology 2002, 130: 224-232. PMID: 12390309, PMCID: PMC1906522, DOI: 10.1046/j.1365-2249.2002.01982.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearB-LymphocytesCD40 LigandCell LineCells, CulturedCoculture TechniquesLupus Erythematosus, SystemicLymphocyte ActivationLymphocyte CooperationMembrane ProteinsMiceMice, Inbred MRL lprMice, KnockoutReceptors, Antigen, T-Cell, alpha-betaReceptors, Tumor Necrosis FactorRibonucleoproteins, Small NuclearTh1 CellsTumor Necrosis Factor-alphaConceptsB cell proliferationTh1 linesTNF-alphaB cellsAntibody productionCell proliferationContact-dependent helpMRL/MpB cell helpMHC class IITh1 cell linesB cell activationCD40-CD154Autoantibody productionTh1 cellsCell helpMRL miceMTNF-alphaProliferative responseHigh titresCell activationTNF-R2Class IITransmembrane formMonoclonal antibodies
1998
Influence of antigen organization on the development of lupus autoantibodies
Fatenejad S, Bennett M, Moslehi J, Craft J. Influence of antigen organization on the development of lupus autoantibodies. Arthritis & Rheumatism 1998, 41: 603-612. PMID: 9550469, DOI: 10.1002/1529-0131(199804)41:4<603::aid-art7>3.0.co;2-e.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodiesAutoantibodiesAutoantigensGene ExpressionHeLa CellsHumansImmune ToleranceImmunizationLupus Erythematosus, SystemicMiceMice, Inbred C57BLMice, Inbred StrainsRecombinant Fusion ProteinsRecombinant ProteinsRibonucleoprotein, U1 Small NuclearRibonucleoproteins, Small NuclearRNA-Binding ProteinsT-LymphocytesTumor Cells, CulturedConceptsSystemic lupus erythematosusDevelopment of antibodiesH-2b backgroundDevelopment of lupusT cell responsesT cell toleranceAssessment of antibodiesNative snRNP particlesTypical immune responseLupus erythematosusAutoimmune responseNormal miceAntigen organizationImmune responseForeign immunogensH-2kCell toleranceMajor autoantigenCell responsesMiceRandom orderAntibodiesEukaryotic expression vectorLupusAutoantigens
1993
Autoantigenic epitopes of the B and D polypeptides of the U1 snRNP. Analysis of domains recognized by the Y12 monoclonal anti-Sm antibody and by patient sera.
Hirakata M, Craft J, Hardin JA. Autoantigenic epitopes of the B and D polypeptides of the U1 snRNP. Analysis of domains recognized by the Y12 monoclonal anti-Sm antibody and by patient sera. The Journal Of Immunology 1993, 150: 3592-601. PMID: 7682245, DOI: 10.4049/jimmunol.150.8.3592.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibodies, MonoclonalAutoantigensBinding Sites, AntibodyEnzyme-Linked Immunosorbent AssayEpitopesHumansImmune SeraLupus Erythematosus, SystemicMiceMolecular Sequence DataProtein ConformationRibonucleoprotein, U1 Small NuclearRibonucleoproteins, Small NuclearSnRNP Core ProteinsConceptsAnti-Sm antibodiesMonoclonal anti-Sm antibodyPatient seraCross-reactive epitopesAutoantigenic epitopesAnti-Sm seraPolypeptide BD polypeptideAnti-Sm patient seraSerumSpecific markersSm small nuclear ribonucleoproteinsEpitopesEnd deletionsAntibodiesImmunoreactive sitesCorresponding synthetic peptideB'/BMAbsDeletion studiesPresent studyLittle amino acid sequence homologySynthetic peptidesAmino acid sequence homologySLEComparison of the drosophila melanogaster, human and murine sm b cDNAs: evolutionary conservation
Brunet C, Quan T, Craft J. Comparison of the drosophila melanogaster, human and murine sm b cDNAs: evolutionary conservation. Gene 1993, 124: 269-273. PMID: 7680326, DOI: 10.1016/0378-1119(93)90404-q.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBiological EvolutionConserved SequenceDrosophila melanogasterEpitopesHeLa CellsHumansImmunoblottingMiceMolecular Sequence DataRibonucleoproteins, Small NuclearConceptsD. melanogaster proteinB polypeptidesConservative aa substitutionsCDNA nucleotide sequenceDeduced aa sequencesC-terminal portionEvolutionary conservationDrosophila melanogasterMouse clonesNucleotide sequenceB proteinSequence identityAa sequencesB cDNAReticulocyte lysateEvolutionary stabilityMurine cellsSpecies linesAmino acidsCDNAProtein BProteinAa substitutionsHuman anti-Sm antibodyCell lines
1992
Autoantigenic epitopes of the b polypeptide of SM small nuclear RNP particles
Ohosone Y, Mimori T, Fujii T, Akizuki M, Matsuoka Y, Irimajiri S, Hardin J, Craft J, Homma M. Autoantigenic epitopes of the b polypeptide of SM small nuclear RNP particles. Arthritis & Rheumatism 1992, 35: 960-966. PMID: 1379432, DOI: 10.1002/art.1780350818.Peer-Reviewed Original ResearchAmino Acid SequenceAutoantigensDNAEpitopesHumansImmunoblottingMolecular Sequence DataPeptidesPrecipitin TestsRibonucleoproteinsRibonucleoproteins, Small NuclearThe murine gene encoding the highly conserved Sm B protein contains a nonfunctional alternative 3′ splice site
Griffith A, Schmauss C, Craft J. The murine gene encoding the highly conserved Sm B protein contains a nonfunctional alternative 3′ splice site. Gene 1992, 114: 195-201. PMID: 1376292, DOI: 10.1016/0378-1119(92)90574-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBiological EvolutionDNAExonsHumansMiceMolecular Sequence DataNucleic Acid ConformationRibonucleoproteinsRibonucleoproteins, Small NuclearRNARNA SplicingSequence Homology, Nucleic AcidConceptsSplice site consensus sequenceAlternative splice sitesSplice siteGenomic sequencesSplice junctionsGenomic nucleotide sequencesAmino acid sequenceSite consensus sequencePutative branch pointGenomic lociMurine geneMurine mRNAHuman genesSm polypeptidesB geneNucleotide sequenceB polypeptidesB proteinAcid sequenceConsensus sequenceExon sequencesHuman cellsSecondary structureMurine tissuesGenes
1990
New RNPs of higher eukaryotes
Craft J, Gold H. New RNPs of higher eukaryotes. Molecular Biology Reports 1990, 14: 97-101. PMID: 2194112, DOI: 10.1007/bf00360432.Peer-Reviewed Original ResearchsnRNPs and scRNPs as autoantigens: clues to the etiology of the connective tissue diseases
Craft J, Mamula M, Ohosone Y, Boire G, Gold H, Hardin J. snRNPs and scRNPs as autoantigens: clues to the etiology of the connective tissue diseases. Clinical Rheumatology 1990, 9: 10-19. PMID: 1697517, DOI: 10.1007/bf02205547.Peer-Reviewed Original Research
1989
Molecular cloning of cDNA encoding Sm autoantigen: derivation of a cDNA for a B polypeptide of the U series of small nuclear ribonucleoprotein particles.
Ohosone Y, Mimori T, Griffith A, Akizuki M, Homma M, Craft J, Hardin JA. Molecular cloning of cDNA encoding Sm autoantigen: derivation of a cDNA for a B polypeptide of the U series of small nuclear ribonucleoprotein particles. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 4249-4253. PMID: 2524838, PMCID: PMC287428, DOI: 10.1073/pnas.86.11.4249.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusSm snRNPsHuman fibroblast cDNA libraryAmino acidsAlternative splicing mechanismLupus erythematosusFibroblast cDNA librarySmall nuclear ribonucleoproteinOpen reading frameAmino acid sequenceSplicing mechanismMolecular cloningCDNA libraryNuclear ribonucleoproteinReading frameAnti-Sm antibodiesB polypeptidesAcid sequenceCOOH terminusNH2 terminusCDNAComplete homologySnRNPsPolypeptide NPolypeptide
1988
The U2 small nuclear ribonucleoprotein particle as an autoantigen. Analysis with sera from patients with overlap syndromes.
Craft J, Mimori T, Olsen TL, Hardin JA. The U2 small nuclear ribonucleoprotein particle as an autoantigen. Analysis with sera from patients with overlap syndromes. Journal Of Clinical Investigation 1988, 81: 1716-1724. PMID: 2968364, PMCID: PMC442616, DOI: 10.1172/jci113511.Peer-Reviewed Original Research