2023
HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease
Little A, Chen P, Vesely M, Khan R, Fiedler J, Garritano J, Islam F, McNiff J, Craft J. HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease. JCI Insight 2023, 8: e166076. PMID: 37526979, PMCID: PMC10543720, DOI: 10.1172/jci.insight.166076.Peer-Reviewed Original ResearchMeSH KeywordsCD8-Positive T-LymphocytesHumansInflammationLupus Erythematosus, CutaneousSkinT-Lymphocytes, CytotoxicConceptsCutaneous lupus erythematosusLupus skin diseaseT cellsSkin diseasesCytotoxic signatureInflammatory infiltrateHIF-1Tissue damageKidney-infiltrating T cellsSkin-infiltrating T cellsAutoimmune skin diseaseHIF-1 inhibitionSkin tissue damageLupus erythematosusSystemic diseaseTissue inflammationGranzyme BMouse modelInflammatory gene programDiseaseProtein levelsInfiltratesSkin environmentGene programPresent studyT follicular helper cells in cancer, tertiary lymphoid structures, and beyond
Cui C, Craft J, Joshi N. T follicular helper cells in cancer, tertiary lymphoid structures, and beyond. Seminars In Immunology 2023, 69: 101797. PMID: 37343412, DOI: 10.1016/j.smim.2023.101797.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsB-LymphocytesCD8-Positive T-LymphocytesHumansNeoplasmsT Follicular Helper CellsTertiary Lymphoid StructuresTumor MicroenvironmentConceptsTumor-associated tertiary lymphoid structuresFollicular helper cellsCD8 T cellsTertiary lymphoid structuresSecondary lymphoid organsT cellsHelper cellsLymphoid structuresImmune cellsB cellsCD4 T follicular helper cellsT Follicular Helper CellsTumor-infiltrating immune cellsCurrent immunotherapy regimensCheckpoint blockade immunotherapyCD4 T cellsImmune cell componentsLimited response rateFunctional immune cellsNovel therapeutic targetPotential therapeutic benefitT cell-B cell interactionsBlockade immunotherapyImmunotherapy regimensLymphoid organs
2022
Tfh-cell-derived interleukin 21 sustains effector CD8+ T cell responses during chronic viral infection
Zander R, Kasmani MY, Chen Y, Topchyan P, Shen J, Zheng S, Burns R, Ingram J, Cui C, Joshi N, Craft J, Zajac A, Cui W. Tfh-cell-derived interleukin 21 sustains effector CD8+ T cell responses during chronic viral infection. Immunity 2022, 55: 475-493.e5. PMID: 35216666, PMCID: PMC8916994, DOI: 10.1016/j.immuni.2022.01.018.Peer-Reviewed Original ResearchConceptsChronic viral infectionsIL-21Cell responsesViral infectionMixed bone marrow chimera experimentsBone marrow chimera experimentsMemory-like subsetTfh cell responsesCell-mediated immunityTfh cellsEffector CD8LCMV infectionHelper subsetsInterleukin-21Th1 cellsViral controlCD8Chimera experimentsCD4InfectionCell differentiationCellsSubsetResponseDistinct populations
2021
Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses
Cui C, Wang J, Fagerberg E, Chen PM, Connolly KA, Damo M, Cheung JF, Mao T, Askari AS, Chen S, Fitzgerald B, Foster GG, Eisenbarth SC, Zhao H, Craft J, Joshi NS. Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses. Cell 2021, 184: 6101-6118.e13. PMID: 34852236, PMCID: PMC8671355, DOI: 10.1016/j.cell.2021.11.007.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAnimalsB-LymphocytesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell Line, TumorHumansInterleukinsLung NeoplasmsMiceMice, Inbred C57BLMice, KnockoutConceptsCD8 TB cellsTfh cellsLung adenocarcinomaTfh-B cell interactionsTumor-specific B cellsFollicular helper cellsAnti-tumor immunityB cell signaturesCell effector functionsGerminal center formationGC B cellsCD4 THelper cellsTumor controlTumor neoantigensEffector functionsCell collaborationCell responsesCell signatureTumor cellsSignature correlatesNeoantigensCell functionCD4
2020
Kidney tissue hypoxia dictates T cell–mediated injury in murine lupus nephritis
Chen PM, Wilson PC, Shyer JA, Veselits M, Steach HR, Cui C, Moeckel G, Clark MR, Craft J. Kidney tissue hypoxia dictates T cell–mediated injury in murine lupus nephritis. Science Translational Medicine 2020, 12 PMID: 32269165, PMCID: PMC8055156, DOI: 10.1126/scitranslmed.aay1620.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD8-Positive T-LymphocytesHypoxiaKidneyLupus Erythematosus, SystemicLupus NephritisMiceConceptsHypoxia-inducible factor-1Lupus nephritisT cellsTissue hypoxiaT-cell-mediated injuryCell-mediated injuryHIF-1 blockadeKidney tissue hypoxiaSystemic lupus erythematosusHuman lupus nephritisMurine lupus nephritisRenal injuryAutoimmune injuryLupus erythematosusAutoimmune diseasesImmune cellsRenal tissueMurine modelTissue damageMore hypoxicNephritisInjuryLow oxygen tensionOxygen tensionFactor 1
2016
The multifaceted role of CD4+ T cells in CD8+ T cell memory
Laidlaw BJ, Craft JE, Kaech SM. The multifaceted role of CD4+ T cells in CD8+ T cell memory. Nature Reviews Immunology 2016, 16: 102-111. PMID: 26781939, PMCID: PMC4860014, DOI: 10.1038/nri.2015.10.Peer-Reviewed Original ResearchMeSH KeywordsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesHumansImmunizationImmunologic MemoryInfectionsVaccinationConceptsT cell responsesT cell poolDendritic cellsT cell helpT cellsMemory CD8Cell helpCell responsesSuppression of DCTissue-resident memory CD8Regulatory T cellsT cell memoryCell poolSuppression of TNFApoptosis-inducing ligandEffector CD4Treg cellsFunctional CD8IL-21Primary CD8Protective immunityInterleukin-15Secondary responsivenessChronic infectionIL-2
2015
A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control
Xin G, Schauder DM, Lainez B, Weinstein JS, Dai Z, Chen Y, Esplugues E, Wen R, Wang D, Parish IA, Zajac AJ, Craft J, Cui W. A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control. Cell Reports 2015, 13: 1118-1124. PMID: 26527008, PMCID: PMC4859432, DOI: 10.1016/j.celrep.2015.09.069.Peer-Reviewed Original ResearchConceptsCD8 T cellsChronic viral infectionsBATF expressionT cellsIL-21Chronic infectionEffector functionsViral infectionCD8 T cell effector functionsAnti-viral effector functionsCD8 T cell responsesCD8 T cell immunityT cell effector functionT cell immunityCD4 T cellsT cell responsesCell effector functionsT cell persistenceT cell maintenanceBlimp-1 expressionCD8 responsesCD4 helpCell immunityViral controlTranscription factor expressionProduction of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells
Laidlaw BJ, Cui W, Amezquita RA, Gray SM, Guan T, Lu Y, Kobayashi Y, Flavell RA, Kleinstein SH, Craft J, Kaech SM. Production of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells. Nature Immunology 2015, 16: 871-879. PMID: 26147684, PMCID: PMC4713030, DOI: 10.1038/ni.3224.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsCD8-Positive T-LymphocytesDendritic CellsFlow CytometryGene Expression ProfilingHost-Pathogen InteractionsImmunologic MemoryInflammationInterleukin-10Lymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMice, Inbred C57BLMice, KnockoutReverse Transcriptase Polymerase Chain ReactionT-Lymphocytes, Regulatory
2014
CD4+ T Cell Help Guides Formation of CD103+ Lung-Resident Memory CD8+ T Cells during Influenza Viral Infection
Laidlaw BJ, Zhang N, Marshall HD, Staron MM, Guan T, Hu Y, Cauley LS, Craft J, Kaech SM. CD4+ T Cell Help Guides Formation of CD103+ Lung-Resident Memory CD8+ T Cells during Influenza Viral Infection. Immunity 2014, 41: 633-645. PMID: 25308332, PMCID: PMC4324721, DOI: 10.1016/j.immuni.2014.09.007.Peer-Reviewed Original ResearchConceptsT cellsTRM cellsT-betTissue-resident memory T cellsLung-resident memory CD8T cell-dependent signalsT cell-derived interferonTranscription factor T-betLung Trm cellsMemory T cellsInfluenza viral infectionInfluenza virus infectionT cell helpHeterosubtypic challengeCD103 expressionMemory CD8Respiratory infectionsMucosal sitesCell helpAirway epitheliumVirus infectionViral infectionInfectionLung airwaysImpaired ability
2012
IL-7Rαlow memory CD8+ T cells are significantly elevated in patients with systemic lupus erythematosus
Kim JS, Cho BA, Sim JH, Shah K, Woo CM, Lee EB, Lee DS, Kang JS, Lee WJ, Park CG, Craft J, Kang I, Kim HR. IL-7Rαlow memory CD8+ T cells are significantly elevated in patients with systemic lupus erythematosus. Rheumatology 2012, 51: 1587-1594. PMID: 22661557, PMCID: PMC3418646, DOI: 10.1093/rheumatology/kes100.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntibodies, BlockingAntigens, CDCD8-Positive T-LymphocytesCoculture TechniquesCytotoxicity, ImmunologicFemaleFlow CytometryHumansImmunologic MemoryImmunophenotypingLupus Erythematosus, SystemicLymphocyte CountReceptors, ImmunologicReceptors, Interleukin-7Signaling Lymphocytic Activation Molecule FamilyConceptsEffector memoryFrequency of ILT cellsHealthy individualsHuman effector memoryTarget cellsSystemic lupus erythematosusPathogenesis of lupusSLE patientsMemory CD8Lupus erythematosusNK cellsCytotoxic functionPeripheral bloodDisease manifestationsPatientsCD48 antigenCytotoxic moleculesFlow cytometrySLECell populationsPotential roleLupusILCellular characteristics
2011
An Interleukin-21- Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8+ T Cells
Cui W, Liu Y, Weinstein JS, Craft J, Kaech SM. An Interleukin-21- Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8+ T Cells. Immunity 2011, 35: 792-805. PMID: 22118527, PMCID: PMC3431922, DOI: 10.1016/j.immuni.2011.09.017.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD8-Positive T-LymphocytesCell DifferentiationGene Expression Regulation, DevelopmentalImmunologic MemoryInterleukin-10InterleukinsMiceMice, KnockoutPositive Regulatory Domain I-Binding Factor 1Proto-Oncogene Proteins c-bcl-6Signal TransductionSTAT3 Transcription FactorSuppressor of Cytokine Signaling 3 ProteinSuppressor of Cytokine Signaling ProteinsT-Box Domain ProteinsTranscription FactorsConceptsMemory T cellsT cellsBCL-6Protective memory T cellsCentral memory T cellsSTAT3 pathwayAcute LCMV infectionExpression of EomesLong-term immunityMemory precursor cellsSTAT3-SOCS3 pathwayMemory cell developmentCell developmentT cell developmentMemory CD8IL-21LCMV infectionIL-12Interleukin-10Inflammatory cytokinesFunctional maturationSOCS3 expressionBlimp-1Precursor cellsSTAT3
2006
γδ T Cells Facilitate Adaptive Immunity against West Nile Virus Infection in Mice
Wang T, Gao Y, Scully E, Davis CT, Anderson JF, Welte T, Ledizet M, Koski R, Madri JA, Barrett A, Yin Z, Craft J, Fikrig E. γδ T Cells Facilitate Adaptive Immunity against West Nile Virus Infection in Mice. The Journal Of Immunology 2006, 177: 1825-1832. PMID: 16849493, DOI: 10.4049/jimmunol.177.3.1825.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsCD8-Positive T-LymphocytesGenetic Predisposition to DiseaseImmunity, CellularImmunity, InnateImmunization, SecondaryImmunoglobulin GImmunoglobulin MImmunologic MemoryLymphocyte DepletionMiceMice, Inbred C57BLMice, KnockoutReceptors, Antigen, T-Cell, gamma-deltaRecurrenceT-Lymphocyte SubsetsWest Nile FeverWest Nile virusConceptsGammadelta T cellsWild-type miceT cellsWN virus infectionPrimary infectionVirus infectionWN virusNaive miceSecondary challengeImmune responseAdaptive immunityCD8 memory T cellsWest Nile virus infectionMemory T cellsProtective immune responseAdaptive immune responsesAdoptive transferWest Nile virusAb responsesLethal infectionViral challengeFatal meningoencephalitisSecondary infectionInfectionMice
2004
Association of reduced CD4 T cell responses specific to varicella zoster virus with high incidence of herpes zoster in patients with systemic lupus erythematosus.
Park HB, Kim KC, Park JH, Kang TY, Lee HS, Kim TH, Jun JB, Bae SC, Yoo DH, Craft J, Jung S. Association of reduced CD4 T cell responses specific to varicella zoster virus with high incidence of herpes zoster in patients with systemic lupus erythematosus. The Journal Of Rheumatology 2004, 31: 2151-5. PMID: 15517626.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusVaricella-zoster virusCD4 T cell responsesT cell frequenciesT cell responsesCD4 T cellsHerpes zosterT cellsHigh incidenceLupus erythematosusZoster virusVZV-specific CD4 T cellsCell frequencyCD4 T-cell frequenciesCell responsesMemory T cellsFlow cytometry analysisVZV reactivationVZV stimulationDisease activityIL-10VZV antigenWhole blood samplesClinical statusRisk factorsDefective Control of Latent Epstein-Barr Virus Infection in Systemic Lupus Erythematosus
Kang I, Quan T, Nolasco H, Park SH, Hong MS, Crouch J, Pamer EG, Howe JG, Craft J. Defective Control of Latent Epstein-Barr Virus Infection in Systemic Lupus Erythematosus. The Journal Of Immunology 2004, 172: 1287-1294. PMID: 14707107, DOI: 10.4049/jimmunol.172.2.1287.Peer-Reviewed Original ResearchMeSH KeywordsAdultB-Lymphocyte SubsetsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCytomegalovirusEpitopes, T-LymphocyteEpstein-Barr Virus InfectionsFemaleHerpesvirus 4, HumanHumansLeukocytes, MononuclearLupus Erythematosus, SystemicLymphocyte CountMaleMiddle AgedSeverity of Illness IndexViral LoadVirus LatencyConceptsSystemic lupus erythematosusEBV viral loadT cell responsesViral loadT cellsIFN-gammaCell responsesEBV infectionLupus erythematosusHealthy controlsEBV-specific T-cell responsesVirus-specific T cell responsesLatent Epstein-Barr virus (EBV) infectionEBV-specific immune responsesEpstein-Barr virus infectionAltered T-cell responsesDefective controlFrequency of CD69HLA-A2 tetramersTetramer-positive CD8Latent EBV infectionEBV-specificImmunosuppressive medicationsDisease activityLupus patients
2003
Oxazolone and diclofenac-induced popliteal lymph node assay reactions are attenuated in mice orally pretreated with the respective compound: potential role for the induction of regulatory mechanisms following enteric administration☆
Gutting BW, Bouzahzah F, Kong PL, Updyke LW, Amacher DE, Craft J. Oxazolone and diclofenac-induced popliteal lymph node assay reactions are attenuated in mice orally pretreated with the respective compound: potential role for the induction of regulatory mechanisms following enteric administration☆. Toxicology And Applied Pharmacology 2003, 189: 120-133. PMID: 12781630, DOI: 10.1016/s0041-008x(03)00091-7.Peer-Reviewed Original ResearchConceptsPopliteal lymph node assayPLN reactionDose-dependent increaseNaive micePLN T cellsT cellsOral toleranceFootpad injectionNaive BALB/c miceBALB/c miceContact sensitizer oxazoloneAdoptive transfer studiesDrug hypersensitivity reactionsLymph node assayEnteric administrationOral pretreatmentHypersensitivity reactionsPopliteal lymphC miceUnfractionated splenocytesNSAID diclofenacB cellsRespective drugsSplenocytesPreclinical assays
2002
IL-10 Regulates Murine Lupus
Yin Z, Bahtiyar G, Zhang N, Liu L, Zhu P, Robert ME, McNiff J, Madaio MP, Craft J. IL-10 Regulates Murine Lupus. The Journal Of Immunology 2002, 169: 2148-2155. PMID: 12165544, DOI: 10.4049/jimmunol.169.4.2148.Peer-Reviewed Original ResearchConceptsIL-10Murine lupusHuman systemic lupus erythematosusAnti-dsDNA autoantibody productionSeverity of lupusTh1 cytokine responseAnti-dsDNA autoantibodiesSystemic lupus erythematosusIFN-gamma productionIL-10 locusMRL/MpJPotential therapeutic benefitLupus syndromeSevere glomerulonephritisSevere lupusLupus modelsLupus erythematosusRIL-10Autoantibody productionCytokine responsesHuman lupusSerum concentrationsProtective effectSkin lesionsLittermate controls