2021
Type I Interferon–Activated STAT4 Regulation of Follicular Helper T Cell–Dependent Cytokine and Immunoglobulin Production in Lupus
Dong X, Antao OQ, Song W, Sanchez GM, Zembrzuski K, Koumpouras F, Lemenze A, Craft J, Weinstein JS. Type I Interferon–Activated STAT4 Regulation of Follicular Helper T Cell–Dependent Cytokine and Immunoglobulin Production in Lupus. Arthritis & Rheumatology 2021, 73: 478-489. PMID: 33512094, PMCID: PMC7914134, DOI: 10.1002/art.41532.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntibody FormationAutoantibodiesB-LymphocytesCase-Control StudiesCytokinesDisease Models, AnimalFemaleHumansImmunoglobulinsInterferon Type IInterferon-gammaInterleukinsLupus Erythematosus, SystemicMaleMice, Inbred MRL lprMiddle AgedRNA-SeqSTAT4 Transcription FactorT Follicular Helper CellsConceptsSystemic lupus erythematosusTfh-like cellsTfh cellsIL-21Human lupusDisease activityCytokine productionSTAT4 activationImmunoglobulin productionPathogenic B cell responsesCourse of lupusClinical disease activityT cell secretionLupus-prone miceHealthy control subjectsCourse of diseaseB cell responsesCytokine interleukin-21Potential therapeutic targetType I IFNB cell maturationSLE patientsPathogenic cytokinesLupus erythematosusInterleukin-21
2012
IL-21 Receptor Is Required for the Systemic Accumulation of Activated B and T Lymphocytes in MRL/MpJ-Faslpr/lpr/J Mice
Rankin AL, Guay H, Herber D, Bertino SA, Duzanski TA, Carrier Y, Keegan S, Senices M, Stedman N, Ryan M, Bloom L, Medley Q, Collins M, Nickerson-Nutter C, Craft J, Young D, Dunussi-Joannopoulos K. IL-21 Receptor Is Required for the Systemic Accumulation of Activated B and T Lymphocytes in MRL/MpJ-Faslpr/lpr/J Mice. The Journal Of Immunology 2012, 188: 1656-1667. PMID: 22231702, PMCID: PMC3618484, DOI: 10.4049/jimmunol.1003871.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantibodiesAutoimmunityB-LymphocytesCD4-Positive T-LymphocytesCell DifferentiationInterferon-gammaInterleukinsLupus Erythematosus, SystemicLymphatic DiseasesLymphocyte ActivationMiceMice, Inbred MRL lprMice, KnockoutReceptors, Interleukin-21SkinSplenomegalyT-Lymphocyte SubsetsT-Lymphocytes, Helper-InducerConceptsT cell effector subsetsIL-21Effector subsetsIL-21RT cellsHelper cellsSpontaneous germinal center formationIL-21-dependent mannerIL-21 receptorMRL/MpJPlasma cell accumulationGerminal center formationTh cell differentiationSignificant reductionAutoantibody titersAutoantibody productionCytokines IFNImmune activationSystemic autoimmunityJ miceDisease manifestationsT lymphocytesPleiotropic cytokineB cellsDisease pathogenesis
2011
Systemic Autoimmunity and Lymphoproliferation Are Associated with Excess IL-7 and Inhibited by IL-7Rα Blockade
Gonzalez-Quintial R, Lawson BR, Scatizzi JC, Craft J, Kono DH, Baccala R, Theofilopoulos AN. Systemic Autoimmunity and Lymphoproliferation Are Associated with Excess IL-7 and Inhibited by IL-7Rα Blockade. PLOS ONE 2011, 6: e27528. PMID: 22102903, PMCID: PMC3213145, DOI: 10.1371/journal.pone.0027528.Peer-Reviewed Original ResearchConceptsT cellsIL-7Systemic autoimmunityIL-7R blockadeIL-7Rα blockadeAutoreactive T cellsMemory T cellsAdvanced disease stageProgression of autoimmunityFibroblastic reticular cellsNovel therapeutic approachesT cell activationAutoimmune manifestationsAutoimmune syndromeCommensal antigensDisease stageIL-7RαTherapeutic approachesLymphocyte homeostasisCell activationReticular cellsAutoimmunityMarked accumulationLupusBlockade
2009
ICOS Controls Effector Function but Not Trafficking Receptor Expression of Kidney-Infiltrating Effector T Cells in Murine Lupus
Odegard JM, DiPlacido LD, Greenwald L, Kashgarian M, Kono DH, Dong C, Flavell RA, Craft J. ICOS Controls Effector Function but Not Trafficking Receptor Expression of Kidney-Infiltrating Effector T Cells in Murine Lupus. The Journal Of Immunology 2009, 182: 4076-4084. PMID: 19299705, PMCID: PMC2746004, DOI: 10.4049/jimmunol.0800758.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, Differentiation, T-LymphocyteAutoantibodiesAutoantigensB-LymphocytesCD4-Positive T-LymphocytesChemokine CXCL9Chemotaxis, LeukocyteCytokinesDisease Models, AnimalEnzyme-Linked Immunosorbent AssayFlow CytometryFluorescent Antibody TechniqueInducible T-Cell Co-Stimulator ProteinKidneyLupus Erythematosus, SystemicLymphocyte ActivationMiceMice, Inbred MRL lprMice, TransgenicP-SelectinReceptors, CCR5Receptors, CXCR3ConceptsCD4 T cellsT cellsPerivascular infiltratesP-selectin ligandsMurine lupusReceptor expressionEffector functionsAutoreactive CD4 T cellsKidney-infiltrating T cellsEffector CD4 T cellsChemokine protein levelsEffector cell numbersIgG autoantibody productionExpression of CXCR3Effector T cellsSystemic lupus erythematosusImmune complex glomerulonephritisCellular inflammatory responseAutoantibody depositionComplex glomerulonephritisLupus erythematosusAutoantibody productionInflammatory chemokinesInflammatory cytokinesLigands CXCL9
2006
Abrogation of skin disease in LUPUS‐prone MRL/FASlpr mice by means of a novel tylophorine analog
Choi J, Gao W, Odegard J, Shiah H, Kashgarian M, McNiff JM, Baker DC, Cheng Y, Craft J. Abrogation of skin disease in LUPUS‐prone MRL/FASlpr mice by means of a novel tylophorine analog. Arthritis & Rheumatism 2006, 54: 3277-3283. PMID: 17009262, DOI: 10.1002/art.22119.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusEnd-organ diseaseInflammatory skin diseaseMRL/Skin diseasesMRL/Faslpr miceFemale MRL/NF-kappaB inhibitorFlow cytometric analysisFaslpr miceAutoantibody titersIgG levelsLupus erythematosusLymph nodesRenal diseaseVehicle treatmentKidney diseaseHepatic toxicityTotal IgMTylophorine analogsAntichromatin autoantibodiesTherapeutic effectHistopathologic analysisMurine modelSignificant abrogation
2005
Naive CD4+ T Cells from Lupus-Prone Fas-Intact MRL Mice Display TCR-Mediated Hyperproliferation Due to Intrinsic Threshold Defects in Activation
Zielinski CE, Jacob SN, Bouzahzah F, Ehrlich BE, Craft J. Naive CD4+ T Cells from Lupus-Prone Fas-Intact MRL Mice Display TCR-Mediated Hyperproliferation Due to Intrinsic Threshold Defects in Activation. The Journal Of Immunology 2005, 174: 5100-5109. PMID: 15814741, DOI: 10.4049/jimmunol.174.8.5100.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAutoimmunityCalcium SignalingCD4-Positive T-LymphocytesCell ProliferationColumbidaeCytochromes cDendritic CellsFas ReceptorGenes, DominantInterleukin-2Lupus Erythematosus, SystemicLymphocyte ActivationMiceMice, Inbred MRL lprMice, Inbred StrainsMice, KnockoutMice, TransgenicPhenotypeReceptor-CD3 Complex, Antigen, T-CellReceptors, Antigen, T-CellSignal TransductionConceptsNaive CD4T cellsSelf-AgAutoreactive T cell activationMRL T cellsT cell toleranceF1 T cellsProximal defectsAnti-CD3 stimulationClass II MHCIL-2 productionT cell activationWild-type CD4Pigeon cytochrome cCell calcium signalingDendritic cellsControl miceMurine lupusObserved hyperactivityII MHCMRL miceIntracellular calciumLow thresholdPeptide AgCD4
2004
The Centromeric Region of Chromosome 7 from MRL Mice (Lmb3) Is an Epistatic Modifier of Fas for Autoimmune Disease Expression
Kong PL, Morel L, Croker BP, Craft J. The Centromeric Region of Chromosome 7 from MRL Mice (Lmb3) Is an Epistatic Modifier of Fas for Autoimmune Disease Expression. The Journal Of Immunology 2004, 172: 2785-2794. PMID: 14978078, DOI: 10.4049/jimmunol.172.5.2785.Peer-Reviewed Original ResearchConceptsMRL/Prototypic systemic autoimmune diseaseDouble-negative T cellsAutoimmune disease expressionEtiology of lupusResistant C57BL/6 backgroundLupus-prone miceSystemic autoimmune diseaseFas-deficient miceT cell activationLupus susceptibility lociAutoantibody productionAutoimmune diseasesKidney diseaseT cellsMRL miceAbsence of Fas
2003
Role of the H‐2 haplotype in Fas‐intact lupus‐prone MRL mice: association with autoantibodies but not renal disease
Kong PL, Zhu T, Madaio MP, Craft J. Role of the H‐2 haplotype in Fas‐intact lupus‐prone MRL mice: association with autoantibodies but not renal disease. Arthritis & Rheumatism 2003, 48: 2992-2995. PMID: 14558109, DOI: 10.1002/art.11308.Peer-Reviewed Original ResearchCD4+ T Cells from Lupus-Prone Mice Avoid Antigen-Specific Tolerance Induction In Vivo
Bouzahzah F, Jung S, Craft J. CD4+ T Cells from Lupus-Prone Mice Avoid Antigen-Specific Tolerance Induction In Vivo. The Journal Of Immunology 2003, 170: 741-748. PMID: 12517936, DOI: 10.4049/jimmunol.170.2.741.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsAutoantigensCD4-Positive T-LymphocytesCell DivisionCell SeparationCells, CulturedClonal AnergyEpitopes, T-LymphocyteGenetic Predisposition to DiseaseLupus NephritisLymphocyte CountMiceMice, Inbred C57BLMice, Inbred CBAMice, Inbred MRL lprMice, TransgenicReceptors, Antigen, T-Cell, alpha-betaConceptsPigeon cytochrome cT cellsIL-2Self-AgCostimulatory signalsAntigen-specific tolerance inductionMRL xTCR transgenic T cellsLupus-prone MRL miceMRL T cellsNormal tolerance mechanismsUbiquitous self-AgsVivo Ag stimulationLupus-prone miceSuch T cellsPeripheral tolerance mechanismsCBA/CaJControl T cellsEx vivo recall assaysActivated T cellsT cell activationInappropriate T-cell activationThymic toleranceMRL/Recall assays
2002
The transmembrane form of TNF-α drives autoantibody production in the absence of CD154: studies using MRL/Mp-Faslpr mice
FUJII T, OKADA M, MIMORI T, CRAFT J. The transmembrane form of TNF-α drives autoantibody production in the absence of CD154: studies using MRL/Mp-Faslpr mice. Clinical & Experimental Immunology 2002, 130: 224-232. PMID: 12390309, PMCID: PMC1906522, DOI: 10.1046/j.1365-2249.2002.01982.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearB-LymphocytesCD40 LigandCell LineCells, CulturedCoculture TechniquesLupus Erythematosus, SystemicLymphocyte ActivationLymphocyte CooperationMembrane ProteinsMiceMice, Inbred MRL lprMice, KnockoutReceptors, Antigen, T-Cell, alpha-betaReceptors, Tumor Necrosis FactorRibonucleoproteins, Small NuclearTh1 CellsTumor Necrosis Factor-alphaConceptsB cell proliferationTh1 linesTNF-alphaB cellsAntibody productionCell proliferationContact-dependent helpMRL/MpB cell helpMHC class IITh1 cell linesB cell activationCD40-CD154Autoantibody productionTh1 cellsCell helpMRL miceMTNF-alphaProliferative responseHigh titresCell activationTNF-R2Class IITransmembrane formMonoclonal antibodiesIL-10 Regulates Murine Lupus
Yin Z, Bahtiyar G, Zhang N, Liu L, Zhu P, Robert ME, McNiff J, Madaio MP, Craft J. IL-10 Regulates Murine Lupus. The Journal Of Immunology 2002, 169: 2148-2155. PMID: 12165544, DOI: 10.4049/jimmunol.169.4.2148.Peer-Reviewed Original ResearchConceptsIL-10Murine lupusHuman systemic lupus erythematosusAnti-dsDNA autoantibody productionSeverity of lupusTh1 cytokine responseAnti-dsDNA autoantibodiesSystemic lupus erythematosusIFN-gamma productionIL-10 locusMRL/MpJPotential therapeutic benefitLupus syndromeSevere glomerulonephritisSevere lupusLupus modelsLupus erythematosusRIL-10Autoantibody productionCytokine responsesHuman lupusSerum concentrationsProtective effectSkin lesionsLittermate controlsRegulation of T cell-dependent autoantibody production by a γδ T cell line derived from lupus-prone mice
Fujii T, Okada M, Craft J. Regulation of T cell-dependent autoantibody production by a γδ T cell line derived from lupus-prone mice. Cellular Immunology 2002, 217: 23-35. PMID: 12425998, DOI: 10.1016/s0008-8749(02)00509-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearApoptosisB-LymphocytesCell LineCoculture TechniquesCytotoxicity Tests, ImmunologicDNAInterleukin-10Lupus Erythematosus, SystemicLymphocyte ActivationLymphocyte CooperationMiceMice, Inbred C57BLMice, Inbred MRL lprMice, KnockoutReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocytes, Helper-InducerTumor Necrosis Factor-alphaConceptsGammadelta T cell linesT cell linesAnti-dsDNA productionMRL/B cellsAutoantibody productionCell linesLupus-prone miceMRL/MpGammadelta T cellsT helper cell linesB cell collaborationActivated B cellsContact-dependent mannerAlphabeta TSevere lupusGammadelta TAutoantibody synthesisMurine lupusLupus-proneT cellsCell collaborationHelper cell lineMiceLupus
2000
Roles of Fas and Fas ligand during mammary gland remodeling
Song J, Sapi E, Brown W, Nilsen J, Tartaro K, Kacinski B, Craft J, Naftolin F, Mor G. Roles of Fas and Fas ligand during mammary gland remodeling. Journal Of Clinical Investigation 2000, 106: 1209-1220. PMID: 11086022, PMCID: PMC381435, DOI: 10.1172/jci10411.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBlotting, WesternCaspase 3CaspasesCell LineCulture MediaCulture Media, Serum-FreeDexamethasoneEpithelial CellsFas Ligand ProteinFas ReceptorFemaleGene ExpressionHumansMammary Glands, AnimalMembrane GlycoproteinsMiceMice, Inbred BALB CMice, Inbred C3HMice, Inbred MRL lprMice, KnockoutPregnancyPregnancy, AnimalRNA, MessengerConceptsMammary epithelial cellsFas/FasL signalsMouse mammary epithelial cellsMammary gland remodelingFasL proteinApoptotic cellsEpithelial cellsInduction of apoptosisAccumulation of cellsSubsequent neoplastic developmentRole of FasMammary gland tissueFasL signalsMammary tissueCell deathExpression of FasFas-FasL interactionMouse mammary tissueMammary cellsCaspase-3Autocrine inductionFas ligandMammary epitheliumNeoplastic developmentTumor development
1998
Central T cell tolerance in lupus-prone mice: influence of autoimmune background and the lpr mutation.
Fatenejad S, Peng SL, Disorbo O, Craft J. Central T cell tolerance in lupus-prone mice: influence of autoimmune background and the lpr mutation. The Journal Of Immunology 1998, 161: 6427-32. PMID: 9834135, DOI: 10.4049/jimmunol.161.11.6427.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsApoptosisAutoimmune DiseasesCell LineClonal DeletionColumbidaeCytochrome c GroupDown-RegulationFas ReceptorGene Rearrangement, alpha-Chain T-Cell Antigen ReceptorImmune ToleranceLupus NephritisLymphocyte ActivationMiceMice, Inbred C57BLMice, Inbred MRL lprMice, TransgenicMolecular Sequence DataMutationPeptidesReceptors, Antigen, T-Cell, alpha-betaT-Lymphocyte SubsetsThymus GlandConceptsMRL/MpJ miceLupus-prone miceT cell toleranceCentral T cell toleranceT cellsLpr mutationCell toleranceSystemic autoimmune diseaseT cell autoreactivityAutoreactive T cellsB cell helpIntrathymic negative selectionMHC class IIMRL/MpJPeripheral control mechanismsAutoimmune backgroundThymic deletionIntrathymic deletionAutoimmune diseasesNonautoimmune miceCell helpTCR transgeneNonautoimmune strainsPeptide AgImmature CD4Perforin protects against autoimmunity in lupus-prone mice.
Peng S, Moslehi J, Robert M, Craft J. Perforin protects against autoimmunity in lupus-prone mice. The Journal Of Immunology 1998, 160: 652-60. PMID: 9551899, DOI: 10.4049/jimmunol.160.2.652.Peer-Reviewed Original ResearchConceptsLupus-prone miceAutoantibody productionImmune complex renal diseaseLupus-prone animalsPerforin-mediated cytotoxicityEnd-organ diseaseComplex renal diseaseAccelerated autoimmunityRenal diseaseLpr miceImmune homeostasisSystemic autoimmunityT cellsImmune systemAbnormal accumulationLpr animalsAutoimmunityFas AgMiceHypergammaglobulinemiaPerforinDiseaseAnimalsSpecific mechanismsRegulatory mechanisms
1997
Roles of interferon-gamma and interleukin-4 in murine lupus.
Peng SL, Moslehi J, Craft J. Roles of interferon-gamma and interleukin-4 in murine lupus. Journal Of Clinical Investigation 1997, 99: 1936-1946. PMID: 9109438, PMCID: PMC508018, DOI: 10.1172/jci119361.Peer-Reviewed Original ResearchConceptsEnd-organ diseaseAutoantibody productionMurine lupusIFN-gammaSerum immunoglobulinsMRL/Mp-lpr/lpr micePathogenic autoantibody productionTiters of IgG2aDevelopment of lupusSystemic autoimmune syndromeAlphabeta T cellsLess IgG1Prototypical Th1Autoimmune syndromeLpr miceProne miceTh2 cytokinesIL-4Comparable levelsTissue injuryT cellsInterleukin-4Critical cytokineLupusLymphadenopathyThe Regulation of Murine Lupusa
PENG S, CRAFT J. The Regulation of Murine Lupusa. Annals Of The New York Academy Of Sciences 1997, 815: 128-138. PMID: 9186650, DOI: 10.1111/j.1749-6632.1997.tb52055.x.Peer-Reviewed Original Researchalpha beta T cell regulation and CD40 ligand dependence in murine systemic autoimmunity.
Peng SL, McNiff JM, Madaio MP, Ma J, Owen MJ, Flavell RA, Hayday AC, Craft J. alpha beta T cell regulation and CD40 ligand dependence in murine systemic autoimmunity. The Journal Of Immunology 1997, 158: 2464-70. PMID: 9036998, DOI: 10.4049/jimmunol.158.5.2464.Peer-Reviewed Original ResearchConceptsAlpha beta T cellsBeta T cellsGamma delta T cellsAutoimmune skin diseaseDelta T cellsT cellsRenal diseaseSystemic autoimmunitySkin diseasesAutoantibody productionMurine lupusCutaneous diseaseT cell-dependent mechanismAlpha betaHigh-titer autoantibodiesLupus-prone miceSevere renal diseaseCell-dependent mechanismT cell regulationCutaneous lesionsCD40 ligandAutoantibodiesAutoimmunityLow titersLpr animals
1996
Systemic autoimmunity in LGJ mice
Peng S, Madaio M, Craft J. Systemic autoimmunity in LGJ mice. Immunology Letters 1996, 53: 153-155. PMID: 9024995, DOI: 10.1016/s0165-2478(96)02616-8.Peer-Reviewed Original ResearchConceptsLG/J miceJ miceAnalysis of autoimmunityEnd-organ diseaseNon-diseased animalsAntinuclear antibodiesInterstitial nephritisLupus erythematosusRenal diseaseRheumatoid factorCutaneous diseaseSystemic autoimmunityMurine modelControl animalsJ strainJ backgroundAutoimmunityDiseaseMiceAutoantibodiesUseful modelAnimalsErythematosusPerivasculitisGlomerulonephritis