2015
Production of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells
Laidlaw BJ, Cui W, Amezquita RA, Gray SM, Guan T, Lu Y, Kobayashi Y, Flavell RA, Kleinstein SH, Craft J, Kaech SM. Production of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells. Nature Immunology 2015, 16: 871-879. PMID: 26147684, PMCID: PMC4713030, DOI: 10.1038/ni.3224.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsCD8-Positive T-LymphocytesDendritic CellsFlow CytometryGene Expression ProfilingHost-Pathogen InteractionsImmunologic MemoryInflammationInterleukin-10Lymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMice, Inbred C57BLMice, KnockoutReverse Transcriptase Polymerase Chain ReactionT-Lymphocytes, Regulatory
2014
B Cells in T Follicular Helper Cell Development and Function: Separable Roles in Delivery of ICOS Ligand and Antigen
Weinstein JS, Bertino SA, Hernandez SG, Poholek AC, Teplitzky TB, Nowyhed HN, Craft J. B Cells in T Follicular Helper Cell Development and Function: Separable Roles in Delivery of ICOS Ligand and Antigen. The Journal Of Immunology 2014, 192: 3166-3179. PMID: 24610013, PMCID: PMC3991608, DOI: 10.4049/jimmunol.1302617.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigensAntigens, CD19B-LymphocytesCell ProliferationDNA-Binding ProteinsFlow CytometryInducible T-Cell Co-Stimulator LigandMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMicroscopy, ConfocalNitrophenolsOvalbuminPhenylacetatesProto-Oncogene Proteins c-bcl-6Reverse Transcriptase Polymerase Chain ReactionT-LymphocytesT-Lymphocytes, Helper-InducerConceptsCognate B cellsTfh cell developmentB cellsICOS ligandFollicular Th cell developmentCell developmentNoncognate B cellsFollicular helper cell developmentTfh cell differentiationAg-specific B cellsICOS-L expressionB cell expressionTh cell developmentGerminal center differentiationICOS blockadeTfh cellsAg deliverySystemic autoimmunityCell expressionCell maturationICOSCellsDeliveryCell differentiationCells display
2011
IL-10 signaling in CD4+ T cells is critical for the pathogenesis of collagen-induced arthritis
Tao J, Kamanaka M, Hao J, Hao Z, Jiang X, Craft JE, Flavell RA, Wu Z, Hong Z, Zhao L, Yin Z. IL-10 signaling in CD4+ T cells is critical for the pathogenesis of collagen-induced arthritis. Arthritis Research & Therapy 2011, 13: r212. PMID: 22192790, PMCID: PMC3334665, DOI: 10.1186/ar3545.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArthritis, ExperimentalCattleCD4-Positive T-LymphocytesCell ProliferationCollagen Type IIFemaleFlow CytometryForkhead Transcription FactorsInterferon-gammaInterleukin-10Interleukin-17Lymphocyte ActivationMaleMiceMice, Inbred C57BLMice, Inbred DBAMice, TransgenicReceptors, Antigen, T-Cell, gamma-deltaReceptors, Interleukin-10Reverse Transcriptase Polymerase Chain ReactionSignal TransductionT-Lymphocytes, RegulatoryConceptsCollagen-induced arthritisIL-10 signalingIL-17 mRNARegulatory T cellsT cell proliferationT cellsT cell activationSuppressive functionImportant anti-inflammatory cytokineBovine type II collagenAnti-inflammatory cytokinesFunction of TregsAbility of TregsSeverity of arthritisLevels of Foxp3Wild-type miceAntigen-specific antibodiesUnpaired t-testMore IFNControl miceCytokine productionTg miceInflammatory jointsFemale miceArthritic joints
2005
Role for macrophage migration inhibitory factor in asthma
Mizue Y, Ghani S, Leng L, McDonald C, Kong P, Baugh J, Lane SJ, Craft J, Nishihira J, Donnelly SC, Zhu Z, Bucala R. Role for macrophage migration inhibitory factor in asthma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 14410-14415. PMID: 16186482, PMCID: PMC1242335, DOI: 10.1073/pnas.0507189102.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAsthmaBase SequenceBronchoalveolar LavageCell ProliferationCells, CulturedCytokinesEnzyme-Linked Immunosorbent AssayFlow CytometryGene ComponentsGenotypeHumansInterleukin-5Intramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMiceMice, Inbred BALB CMice, KnockoutOvalbuminReverse Transcriptase Polymerase Chain ReactionT-Lymphocytes, Helper-InducerConceptsMacrophage migration inhibitory factorMigration inhibitory factorInhibitory factorIL-5 concentrationsLower airway hyperresponsivenessBronchoalveolar lavage fluidAntigen-specific responsesT-cell studiesWild-type miceLess pulmonary inflammationAirway hyperresponsivenessImmunologic regulatorsMIF deficiencyMIF KOMIF's roleMild asthmaWild-type controlsSevere asthmaAsthma patientsCytokine levelsMIF genotypePulmonary inflammationSpecific IgEWhite patientsAutoimmune disorders