2010
Epstein‐Barr virus promotes interferon‐α production by plasmacytoid dendritic cells
Quan TE, Roman RM, Rudenga BJ, Holers VM, Craft JE. Epstein‐Barr virus promotes interferon‐α production by plasmacytoid dendritic cells. Arthritis & Rheumatism 2010, 62: 1693-1701. PMID: 20178121, PMCID: PMC2885535, DOI: 10.1002/art.27408.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, NuclearDendritic CellsDose-Response Relationship, ImmunologicEnzyme-Linked Immunosorbent AssayFlow CytometryHerpesvirus 4, HumanHumansImmunity, HumoralInterferon-alphaLupus Erythematosus, SystemicMajor Histocompatibility ComplexStatistics, NonparametricToll-Like Receptor 7Toll-Like Receptor 9ConceptsPlasmacytoid dendritic cellsSystemic lupus erythematosusHuman plasmacytoid dendritic cellsIFNalpha productionDendritic cellsEpstein-Barr virus infectionToll-like receptor 9Interferon-alpha levelsPresence of EBVChronic viral infectionsElevated viral loadAbility of EBVInnate immune cellsEpstein-Barr virusMajor histocompatibility complex moleculesInnate immune responseEnzyme-linked immunosorbent assayHistocompatibility complex moleculesSLE patientsEBV DNATLR-7Lupus erythematosusViral loadReceptor 9Immune cells
1995
Molecular Structure and Function of Autoantigens in Systemic Sclerosis
Lee B, Craft J. Molecular Structure and Function of Autoantigens in Systemic Sclerosis. International Reviews Of Immunology 1995, 12: 129-144. PMID: 7650417, DOI: 10.3109/08830189509056708.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, NuclearAutoantigensChromosomal Proteins, Non-HistoneDNA HelicasesDNA Topoisomerases, Type IDNA-Binding ProteinsDNA-Directed RNA PolymerasesEndoribonucleasesExoribonucleasesExosome Multienzyme Ribonuclease ComplexHumansKinetochoresKu AutoantigenNuclear ProteinsPol1 Transcription Initiation Complex ProteinsRibonucleoproteinsScleroderma, SystemicTranscription Factors
1993
Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks.
Blier PR, Griffith AJ, Craft J, Hardin JA. Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks. Journal Of Biological Chemistry 1993, 268: 7594-7601. PMID: 8463290, DOI: 10.1016/s0021-9258(18)53216-6.Peer-Reviewed Original Research
1992
Nucleotide sequence and genomic structure analyses of the p70 subunit of the human Ku autoantigen: evidence for a family of genes encoding Ku (p70)-related polypeptides
Griffith A, Craft J, Evans J, Mimori T, Hardin J. Nucleotide sequence and genomic structure analyses of the p70 subunit of the human Ku autoantigen: evidence for a family of genes encoding Ku (p70)-related polypeptides. Molecular Biology Reports 1992, 16: 91-97. PMID: 1608402, DOI: 10.1007/bf00419754.Peer-Reviewed Original ResearchConceptsHuman Ku autoantigenKu autoantigenGenomic structure analysisFamily of genesHomologous DNA sequencesOpen reading frameEntire open reading frameNucleotide sequence analysisAmino acid polymorphismsSouthern blot analysisP70 polypeptidesHuman genomeReading frameDNA sequencesNucleotide sequenceP70 subunitMultiple genesExpression analysisSequence analysisAcid polymorphismsMultiple copiesBlot analysisPolypeptideGenesSequence