2015
The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells
Ray JP, Staron MM, Shyer JA, Ho PC, Marshall HD, Gray SM, Laidlaw BJ, Araki K, Ahmed R, Kaech SM, Craft J. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity 2015, 43: 690-702. PMID: 26410627, PMCID: PMC4618086, DOI: 10.1016/j.immuni.2015.08.017.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCalcium SignalingCell CycleCell DivisionEnzyme ActivationGlucoseGlycolysisInterleukin-2Interleukin-2 Receptor alpha SubunitLymphocytic choriomeningitis virusMechanistic Target of Rapamycin Complex 1Mice, Inbred C57BLMultiprotein ComplexesNFATC Transcription FactorsOxygen ConsumptionPositive Regulatory Domain I-Binding Factor 1Proto-Oncogene Proteins c-aktSignal TransductionSpecific Pathogen-Free OrganismsTh1 CellsT-Lymphocyte SubsetsT-Lymphocytes, Helper-InducerTOR Serine-Threonine KinasesTranscription FactorsConceptsFollicular B helper T cellsAcute viral infectionHelper T cellsTfh cellsT cellsViral infectionT helper 1 cellsHelper T cell subsetsIL-2-mediated activationT cell subsetsDiverse effector functionsT helper 1Dependent cytokine productionTh1 cell fateHelper 1Cell subsetsCytokine productionTh1 cellsInterleukin-2Effector functionsCritical orchestratorsMTOR kinase activityLess proliferationMTORC1 axisReciprocal balance
2004
Resistance to Development of Collagen-Induced Arthritis in C57BL/6 Mice Is Due to a Defect in Secondary, but Not in Primary, Immune Response
Pan M, Kang I, Craft J, Yin Z. Resistance to Development of Collagen-Induced Arthritis in C57BL/6 Mice Is Due to a Defect in Secondary, but Not in Primary, Immune Response. Journal Of Clinical Immunology 2004, 24: 481-491. PMID: 15359107, DOI: 10.1023/b:joci.0000040919.16739.44.Peer-Reviewed Original ResearchConceptsCollagen-induced arthritisB6 miceImmune responseSimilar T cell proliferationBovine type II collagenB cell immune responsesH-2b backgroundAnti-CII antibodiesHuman rheumatoid arthritisT cell responsesCell immune responsesSecondary immune responseT cell proliferationCII AbsCytokine responsesRheumatoid arthritisInitial immunizationC57BL/6 miceRodent modelsArthritisType II collagenDay 14Cell responsesDay 12MiceActivation of Naive CD4+ T Cells In Vivo by a Self-Peptide Mimic: Mechanism of Tolerance Maintenance and Preservation of Immunity
Choi JY, Craft J. Activation of Naive CD4+ T Cells In Vivo by a Self-Peptide Mimic: Mechanism of Tolerance Maintenance and Preservation of Immunity. The Journal Of Immunology 2004, 172: 7399-7407. PMID: 15187117, DOI: 10.4049/jimmunol.172.12.7399.Peer-Reviewed Original ResearchConceptsSelf peptide-MHC complexesT cellsTolerance maintenanceCostimulatory signalsMHC complexesNaive T cellsTCR engagementIntrathymic selectionNaive CD4Peripheral repertoireStrong costimulationForeign AgsAgonist peptideMicrobial challengeSurviving cellsNovel mechanismCellsVivoSubsequent encountersLow affinityPathogen challengeDividing cellsCD4CD69Restimulation
2003
IFN-γ-Producing γδ T Cells Help Control Murine West Nile Virus Infection
Wang T, Scully E, Yin Z, Kim JH, Wang S, Yan J, Mamula M, Anderson JF, Craft J, Fikrig E. IFN-γ-Producing γδ T Cells Help Control Murine West Nile Virus Infection. The Journal Of Immunology 2003, 171: 2524-2531. PMID: 12928402, DOI: 10.4049/jimmunol.171.5.2524.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsBloodCell DivisionCells, CulturedCytotoxicity, ImmunologicEncephalitis, ViralFemaleGenes, T-Cell Receptor betaGenes, T-Cell Receptor deltaGenetic Predisposition to DiseaseInterferon-gammaLymphoid TissueMiceMice, Inbred C57BLMice, KnockoutReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaSeverity of Illness IndexT-Lymphocyte SubsetsViral LoadWest Nile FeverWest Nile virusConceptsGammadelta T cellsWN virus infectionT cellsVirus infectionIFN-gamma-producing gammadelta T cellsWest Nile virus infectionPrevention of mortalityΓδ T cellsSplenic T cellsWild-type miceEx vivo assaysAdoptive transferWest Nile virusPerforin expressionViral loadFatal meningoencephalitisIFN-gammaMiceInfectionWN virusNile virusVivo assaysLaboratory miceCellsVirusCD4+ T Cells from Lupus-Prone Mice Avoid Antigen-Specific Tolerance Induction In Vivo
Bouzahzah F, Jung S, Craft J. CD4+ T Cells from Lupus-Prone Mice Avoid Antigen-Specific Tolerance Induction In Vivo. The Journal Of Immunology 2003, 170: 741-748. PMID: 12517936, DOI: 10.4049/jimmunol.170.2.741.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsAutoantigensCD4-Positive T-LymphocytesCell DivisionCell SeparationCells, CulturedClonal AnergyEpitopes, T-LymphocyteGenetic Predisposition to DiseaseLupus NephritisLymphocyte CountMiceMice, Inbred C57BLMice, Inbred CBAMice, Inbred MRL lprMice, TransgenicReceptors, Antigen, T-Cell, alpha-betaConceptsPigeon cytochrome cT cellsIL-2Self-AgCostimulatory signalsAntigen-specific tolerance inductionMRL xTCR transgenic T cellsLupus-prone MRL miceMRL T cellsNormal tolerance mechanismsUbiquitous self-AgsVivo Ag stimulationLupus-prone miceSuch T cellsPeripheral tolerance mechanismsCBA/CaJControl T cellsEx vivo recall assaysActivated T cellsT cell activationInappropriate T-cell activationThymic toleranceMRL/Recall assays
2001
Cd4+ T Cells from Lupus-Prone Mice Are Hyperresponsive to T Cell Receptor Engagement with Low and High Affinity Peptide Antigens
Vratsanos G, Jung S, Park Y, Craft J. Cd4+ T Cells from Lupus-Prone Mice Are Hyperresponsive to T Cell Receptor Engagement with Low and High Affinity Peptide Antigens. Journal Of Experimental Medicine 2001, 193: 329-338. PMID: 11157053, PMCID: PMC2195926, DOI: 10.1084/jem.193.3.329.Peer-Reviewed Original ResearchConceptsT cell receptorLupus-prone miceT cellsT cell activationPigeon cytochrome cAlpha/beta T cellsCell activationTransgenic T cell receptorBeta T cellsAntigen-presenting cellsCBA/CaJT cell receptor engagementLow affinityBeta-chain geneMRL/Cell receptor engagementPolyclonal activationSpontaneous lupusAmino acids 88Cognate antigenCell receptorAntigenPeptide ligandsReceptor engagementLupus
1995
T cells with gamma/delta T cell receptors (TCR) of intestinal type are preferentially expanded in TCR-alpha-deficient lpr mice.
Hughes DP, Hayday A, Craft JE, Owen MJ, Crispe IN. T cells with gamma/delta T cell receptors (TCR) of intestinal type are preferentially expanded in TCR-alpha-deficient lpr mice. Journal Of Experimental Medicine 1995, 182: 233-241. PMID: 7540652, PMCID: PMC2192080, DOI: 10.1084/jem.182.1.233.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, SurfaceApoptosisBase SequenceCell DivisionCell MovementDNA Transposable ElementsFas ReceptorImmunophenotypingIntestinal MucosaLymph NodesLymphocyte CountLymphoproliferative DisordersMiceMice, KnockoutMice, Mutant StrainsMolecular Sequence DataReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaSpecific Pathogen-Free OrganismsT-Lymphocyte SubsetsConceptsLpr/lpr miceT cell receptorIntestinal intraepithelial lymphocytesLpr miceT cellsIntraepithelial lymphocytesAlpha/beta T cellsGamma/delta T cell receptorGamma/delta T cellsLymph node cell numberTCR gamma/deltaDelta T-cell receptorFas-deficient lpr micePeripheral lymphoid systemT-cell contributionPeripheral lymph nodesBeta T cellsDelta T cellsActivation-induced cell deathGene-ablated miceRole of FasT cell developmentLymph nodesIntestinal typeLymphoid system