2012
Caspase‐activated DNase is required for maintenance of tolerance to lupus nuclear autoantigens
Jog NR, Frisoni L, Shi Q, Monestier M, Hernandez S, Craft J, Prak ET, Caricchio R. Caspase‐activated DNase is required for maintenance of tolerance to lupus nuclear autoantigens. Arthritis & Rheumatism 2012, 64: 1247-1256. PMID: 22127758, PMCID: PMC3292632, DOI: 10.1002/art.33448.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusAutoimmune responseMouse modelApoptotic cellsNuclear autoantigensDNA antibody titersLupus-prone miceAbsence of CADMaintenance of toleranceAutoreactive B cellsAnti-DNA antibodiesApoptotic modificationsLupus developmentGeneration of autoantigensAntinuclear antibodiesLupus erythematosusAntibody titersAutoimmune diseasesActive caspase-3Apoptotic bodiesB cellsMiceAutoantigensCAD deficiencyCaspase-3
1992
Autoantibodies to small nuclear and cytoplasmic ribonucleoproteins in japanese patients with inflammatory muscle disease
Hirakata M, Mimori T, Akizuki M, Craft J, Hardin J, Homma M. Autoantibodies to small nuclear and cytoplasmic ribonucleoproteins in japanese patients with inflammatory muscle disease. Arthritis & Rheumatism 1992, 35: 449-456. PMID: 1567494, DOI: 10.1002/art.1780350415.Peer-Reviewed Original ResearchConceptsInflammatory muscle diseaseJapanese patientsChronic interstitial lung diseaseMuscle diseaseAnti-PM/SclDifferent etiologic mechanismsTRNA synthetase antibodiesDistinct clinical subsetInterstitial lung diseasePM/DMControl patientsImmunogenetic backgroundOverlap syndromeClinical subsetsRheumatic diseasesSevere myositisAutoimmune responseRNP antibodiesAutoantibody specificitiesLung diseaseClinical correlationClinical significanceClinical comparisonSynthetase antibodiesEtiologic mechanisms
1991
PBC 95K, a 95‐kilodalton nuclear autoantigen in primary biliary cirrhosis
Evans J, Reuben A, Craft J. PBC 95K, a 95‐kilodalton nuclear autoantigen in primary biliary cirrhosis. Arthritis & Rheumatism 1991, 34: 731-736. PMID: 2053918, DOI: 10.1002/art.1780340614.Peer-Reviewed Original ResearchMeSH KeywordsAutoantigensCell NucleusFluorescent Antibody TechniqueHeLa CellsHumansLiver Cirrhosis, BiliaryMolecular WeightConceptsPrimary biliary cirrhosisAntinuclear antibodiesBiliary cirrhosisANA-positive samplesConnective tissue diseaseSera of patientsANA-positive seraHEp-2 cellsPBC patientsLiver diseaseTissue diseaseNuclear dotsPatientsIndirect immunofluorescenceNuclear autoantigensStaining patternAffinity-purified antibodiesSerumAntibodiesCirrhosisDiseaseAutoantigensTiters
1989
The RNA Processing Enzyme RNase MRP Is Identical to the Th RNP and Related to RNase P
Gold H, Topper J, Clayton D, Craft J. The RNA Processing Enzyme RNase MRP Is Identical to the Th RNP and Related to RNase P. Science 1989, 245: 1377-1380. PMID: 2476849, DOI: 10.1126/science.2476849.Peer-Reviewed Original ResearchConceptsRNA processing enzymesRNase MRPMitochondrial RNA processing enzymeProcessing enzymesRNase MRP activityHuman cell extractsNucleotide sequence analysisRNP enzymeEukaryotic cellsRibonuclease PBiochemical purificationRNase PRNA componentRNA transcriptsSequence analysisCell extractsRNPMRP activityEnzymeMRPTerminusMitochondriaTranscriptsPolypeptideBindsHigher order structure is present in the yeast nucleus: autoantibody probes demonstrate that the nucleolus lies opposite the spindle pole body
Yang C, Lambie E, Hardin J, Craft J, Snyder M. Higher order structure is present in the yeast nucleus: autoantibody probes demonstrate that the nucleolus lies opposite the spindle pole body. Chromosoma 1989, 98: 123-128. PMID: 2673672, DOI: 10.1007/bf00291048.Peer-Reviewed Original Research