Perforin protects against autoimmunity in lupus-prone mice.
Peng S, Moslehi J, Robert M, Craft J. Perforin protects against autoimmunity in lupus-prone mice. The Journal Of Immunology 1998, 160: 652-60. PMID: 9551899, DOI: 10.4049/jimmunol.160.2.652.Peer-Reviewed Original ResearchConceptsLupus-prone miceAutoantibody productionImmune complex renal diseaseLupus-prone animalsPerforin-mediated cytotoxicityEnd-organ diseaseComplex renal diseaseAccelerated autoimmunityRenal diseaseLpr miceImmune homeostasisSystemic autoimmunityT cellsImmune systemAbnormal accumulationLpr animalsAutoimmunityFas AgMiceHypergammaglobulinemiaPerforinDiseaseAnimalsSpecific mechanismsRegulatory mechanisms