2016
TFH cells progressively differentiate to regulate the germinal center response
Weinstein JS, Herman EI, Lainez B, Licona-Limón P, Esplugues E, Flavell R, Craft J. TFH cells progressively differentiate to regulate the germinal center response. Nature Immunology 2016, 17: 1197-1205. PMID: 27573866, PMCID: PMC5030190, DOI: 10.1038/ni.3554.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibody AffinityB-LymphocytesCD4 AntigensCell CommunicationCell DifferentiationCells, CulturedGene Expression RegulationGerminal CenterHumansInterleukin-4InterleukinsMiceMice, Inbred C57BLMice, Mutant StrainsMutationNippostrongylusPositive Regulatory Domain I-Binding Factor 1Strongylida InfectionsT-Lymphocytes, Helper-InducerTranscription Factors
2015
A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control
Xin G, Schauder DM, Lainez B, Weinstein JS, Dai Z, Chen Y, Esplugues E, Wen R, Wang D, Parish IA, Zajac AJ, Craft J, Cui W. A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control. Cell Reports 2015, 13: 1118-1124. PMID: 26527008, PMCID: PMC4859432, DOI: 10.1016/j.celrep.2015.09.069.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasic-Leucine Zipper Transcription FactorsCD8-Positive T-LymphocytesCells, CulturedInterferon Regulatory FactorsInterleukinsMiceMice, Inbred C57BLPositive Regulatory Domain I-Binding Factor 1Transcription FactorsVirus DiseasesConceptsCD8 T cellsChronic viral infectionsBATF expressionT cellsIL-21Chronic infectionEffector functionsViral infectionCD8 T cell effector functionsAnti-viral effector functionsCD8 T cell responsesCD8 T cell immunityT cell effector functionT cell immunityCD4 T cellsT cell responsesCell effector functionsT cell persistenceT cell maintenanceBlimp-1 expressionCD8 responsesCD4 helpCell immunityViral controlTranscription factor expressionThe Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells
Ray JP, Staron MM, Shyer JA, Ho PC, Marshall HD, Gray SM, Laidlaw BJ, Araki K, Ahmed R, Kaech SM, Craft J. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity 2015, 43: 690-702. PMID: 26410627, PMCID: PMC4618086, DOI: 10.1016/j.immuni.2015.08.017.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCalcium SignalingCell CycleCell DivisionEnzyme ActivationGlucoseGlycolysisInterleukin-2Interleukin-2 Receptor alpha SubunitLymphocytic choriomeningitis virusMechanistic Target of Rapamycin Complex 1Mice, Inbred C57BLMultiprotein ComplexesNFATC Transcription FactorsOxygen ConsumptionPositive Regulatory Domain I-Binding Factor 1Proto-Oncogene Proteins c-aktSignal TransductionSpecific Pathogen-Free OrganismsTh1 CellsT-Lymphocyte SubsetsT-Lymphocytes, Helper-InducerTOR Serine-Threonine KinasesTranscription FactorsConceptsFollicular B helper T cellsAcute viral infectionHelper T cellsTfh cellsT cellsViral infectionT helper 1 cellsHelper T cell subsetsIL-2-mediated activationT cell subsetsDiverse effector functionsT helper 1Dependent cytokine productionTh1 cell fateHelper 1Cell subsetsCytokine productionTh1 cellsInterleukin-2Effector functionsCritical orchestratorsMTOR kinase activityLess proliferationMTORC1 axisReciprocal balance
2011
An Interleukin-21- Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8+ T Cells
Cui W, Liu Y, Weinstein JS, Craft J, Kaech SM. An Interleukin-21- Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8+ T Cells. Immunity 2011, 35: 792-805. PMID: 22118527, PMCID: PMC3431922, DOI: 10.1016/j.immuni.2011.09.017.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD8-Positive T-LymphocytesCell DifferentiationGene Expression Regulation, DevelopmentalImmunologic MemoryInterleukin-10InterleukinsMiceMice, KnockoutPositive Regulatory Domain I-Binding Factor 1Proto-Oncogene Proteins c-bcl-6Signal TransductionSTAT3 Transcription FactorSuppressor of Cytokine Signaling 3 ProteinSuppressor of Cytokine Signaling ProteinsT-Box Domain ProteinsTranscription FactorsConceptsMemory T cellsT cellsBCL-6Protective memory T cellsCentral memory T cellsSTAT3 pathwayAcute LCMV infectionExpression of EomesLong-term immunityMemory precursor cellsSTAT3-SOCS3 pathwayMemory cell developmentCell developmentT cell developmentMemory CD8IL-21LCMV infectionIL-12Interleukin-10Inflammatory cytokinesFunctional maturationSOCS3 expressionBlimp-1Precursor cellsSTAT3
2009
Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation
Johnston RJ, Poholek AC, DiToro D, Yusuf I, Eto D, Barnett B, Dent AL, Craft J, Crotty S. Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation. Science 2009, 325: 1006-1010. PMID: 19608860, PMCID: PMC2766560, DOI: 10.1126/science.1175870.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibody FormationArenaviridae InfectionsB-LymphocytesCD4-Positive T-LymphocytesCell DifferentiationCell LineageCytokinesDNA-Binding ProteinsGene Expression RegulationGerminal CenterLymphocyte ActivationLymphocytic choriomeningitis virusMiceMice, Inbred C57BLMice, TransgenicPositive Regulatory Domain I-Binding Factor 1Proto-Oncogene Proteins c-bcl-6RNA, MessengerSignal TransductionT-Lymphocyte SubsetsT-Lymphocytes, Helper-InducerTranscription FactorsConceptsAntibody responseT cellsBlimp-1B cell germinal centersEffector T cell subsetsFollicular helper cell differentiationT Follicular Helper Cell DifferentiationFollicular helper cellsB cell-mediated immunityCell-mediated immunityT cell subsetsB cell responsesT cell helpTranscription factor Blimp-1Transcription factor Bcl6Helper cell differentiationDistinct CD4Cell subsetsHelper cellsCell helpGerminal centersB cellsCell responsesCD4BCL6