2004
Defective Control of Latent Epstein-Barr Virus Infection in Systemic Lupus Erythematosus
Kang I, Quan T, Nolasco H, Park SH, Hong MS, Crouch J, Pamer EG, Howe JG, Craft J. Defective Control of Latent Epstein-Barr Virus Infection in Systemic Lupus Erythematosus. The Journal Of Immunology 2004, 172: 1287-1294. PMID: 14707107, DOI: 10.4049/jimmunol.172.2.1287.Peer-Reviewed Original ResearchMeSH KeywordsAdultB-Lymphocyte SubsetsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCytomegalovirusEpitopes, T-LymphocyteEpstein-Barr Virus InfectionsFemaleHerpesvirus 4, HumanHumansLeukocytes, MononuclearLupus Erythematosus, SystemicLymphocyte CountMaleMiddle AgedSeverity of Illness IndexViral LoadVirus LatencyConceptsSystemic lupus erythematosusEBV viral loadT cell responsesViral loadT cellsIFN-gammaCell responsesEBV infectionLupus erythematosusHealthy controlsEBV-specific T-cell responsesVirus-specific T cell responsesLatent Epstein-Barr virus (EBV) infectionEBV-specific immune responsesEpstein-Barr virus infectionAltered T-cell responsesDefective controlFrequency of CD69HLA-A2 tetramersTetramer-positive CD8Latent EBV infectionEBV-specificImmunosuppressive medicationsDisease activityLupus patients
1993
Identification of autoantibodies to RNA polymerase II. Occurrence in systemic sclerosis and association with autoantibodies to RNA polymerases I and III.
Hirakata M, Okano Y, Pati U, Suwa A, Medsger TA, Hardin JA, Craft J. Identification of autoantibodies to RNA polymerase II. Occurrence in systemic sclerosis and association with autoantibodies to RNA polymerases I and III. Journal Of Clinical Investigation 1993, 91: 2665-2672. PMID: 8390487, PMCID: PMC443330, DOI: 10.1172/jci116505.Peer-Reviewed Original ResearchConceptsSystemic sclerosisII antibodiesAnti-RNA polymerase II antibodiesLimited cutaneous diseaseConnective tissue diseaseIdentification of autoantibodiesSera of patientsIndirect immunofluorescence studiesHuman serumTissue diseaseCutaneous diseaseNormal controlsAutoantibodiesSclerosisPatientsHuman antibodiesRNA polymerase IIClinical perspectiveMonoclonal antibodiesAntibodiesSerumRNA polymerase IImmunofluorescence studiesImmunodepletion studiesFurther studies