1992
Prevention of Lyme Disease after Tick Bites
Magid D, Schwartz B, Craft J, Schwartz J. Prevention of Lyme Disease after Tick Bites. New England Journal Of Medicine 1992, 327: 534-541. PMID: 1298217, DOI: 10.1056/nejm199208203270806.Peer-Reviewed Original ResearchConceptsTick biteProbability of infectionLyme diseaseOnly patientsEmpirical therapyErythema migransEmpirical treatmentBurgdorferi infectionAdditional minor complicationsMost major complicationsWeeks of doxycyclinePositive serologic testsDisease one monthEndemic Lyme diseaseBorrelia burgdorferi infectionB. burgdorferi infectionAdverse eventsMinor complicationsMost complicationsMajor complicationsEarly treatmentSerologic testsPatientsComplicationsInfection
1986
Clinical manifestations of lyme disease
Steere A, Bartenhagen N, Craft J, Hutchinson G, Newman J, Pachner A, Rahn D, Sigal L, Taylor E, Malawista S. Clinical manifestations of lyme disease. International Journal Of Medical Microbiology 1986, 263: 201-205. PMID: 3554839, DOI: 10.1016/s0176-6724(86)80123-7.Peer-Reviewed Original ResearchConceptsMigratory musculoskeletal painErythema chronicum migransLyme diseaseMusculoskeletal painClinical manifestationsUnique skin lesionNon-productive coughDifferent clinical manifestationsFrank arthritisMononeuritis multiplexAcute myopericarditisCardiac involvementCranial neuritisSkin involvementUrticarial rashSore throatNeurologic abnormalitiesPeriorbital edemaAV blockDisease onsetSecondary lesionsSkin lesionsPatientsDiseaseLesions
1983
Treatment of the early manifestations of Lyme disease.
Steere AC, Hutchinson GJ, Rahn DW, Sigal LH, Craft JE, DeSanna ET, Malawista SE. Treatment of the early manifestations of Lyme disease. Annals Of Internal Medicine 1983, 99: 22-6. PMID: 6407378, DOI: 10.7326/0003-4819-99-1-22.Peer-Reviewed Original ResearchConceptsEarly Lyme diseaseAdult patientsLyme diseaseMajor late complicationsPenicillin-treated patientsTetracycline-treated patientsAntibiotic regimensLate complicationsMajor complicationsMusculoskeletal painInitial severityLate symptomsEffective drugsPatientsEarly manifestationAntibiotic agentsComplicationsDiseaseSymptomsErythromycinPenicillinTetracyclinePainRegimensHeadacheThe early clinical manifestations of Lyme disease.
Steere AC, Bartenhagen NH, Craft JE, Hutchinson GJ, Newman JH, Rahn DW, Sigal LH, Spieler PN, Stenn KS, Malawista SE. The early clinical manifestations of Lyme disease. Annals Of Internal Medicine 1983, 99: 76-82. PMID: 6859726, DOI: 10.7326/0003-4819-99-1-76.Peer-Reviewed Original ResearchConceptsLyme diseaseSkin lesionsElevated serum IgM levelsMigratory musculoskeletal painTick-transmitted spirochetesUnique skin lesionAspartate transaminase levelsEarly clinical manifestationsEarly Lyme diseaseSerum IgM levelsErythema chronicum migransMeningeal irritationLaboratory abnormalitiesNonproductive coughTransaminase levelsUrticarial rashMusculoskeletal painRegional lymphadenopathySkin manifestationsSore throatDermatologic manifestationsSerologic testingClinical manifestationsIgM levelsPeriorbital edemaThe Spirochetal Etiology of Lyme Disease
Steere A, Grodzicki R, Kornblatt A, Craft J, Barbour A, Burgdorfer W, Schmid G, Johnson E, Malawista S. The Spirochetal Etiology of Lyme Disease. New England Journal Of Medicine 1983, 308: 733-740. PMID: 6828118, DOI: 10.1056/nejm198303313081301.Peer-Reviewed Original ResearchConceptsLyme diseaseAntibody titersIgM titersSpecific IgM antibody titersSpecific IgG antibody titersElevated IgM titersI. dammini spirocheteIgG antibody titersIgM antibody titersTiters of IgGOnset of diseaseInfectious mononucleosisControl patientsImmunologic featuresIgG titersEarly diseaseControl subjectsSpirochetal etiologySkin lesionsCerebrospinal fluidPatientsLate manifestationSixth weekDiseaseTiters