2021
Type I Interferon–Activated STAT4 Regulation of Follicular Helper T Cell–Dependent Cytokine and Immunoglobulin Production in Lupus
Dong X, Antao OQ, Song W, Sanchez GM, Zembrzuski K, Koumpouras F, Lemenze A, Craft J, Weinstein JS. Type I Interferon–Activated STAT4 Regulation of Follicular Helper T Cell–Dependent Cytokine and Immunoglobulin Production in Lupus. Arthritis & Rheumatology 2021, 73: 478-489. PMID: 33512094, PMCID: PMC7914134, DOI: 10.1002/art.41532.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntibody FormationAutoantibodiesB-LymphocytesCase-Control StudiesCytokinesDisease Models, AnimalFemaleHumansImmunoglobulinsInterferon Type IInterferon-gammaInterleukinsLupus Erythematosus, SystemicMaleMice, Inbred MRL lprMiddle AgedRNA-SeqSTAT4 Transcription FactorT Follicular Helper CellsConceptsSystemic lupus erythematosusTfh-like cellsTfh cellsIL-21Human lupusDisease activityCytokine productionSTAT4 activationImmunoglobulin productionPathogenic B cell responsesCourse of lupusClinical disease activityT cell secretionLupus-prone miceHealthy control subjectsCourse of diseaseB cell responsesCytokine interleukin-21Potential therapeutic targetType I IFNB cell maturationSLE patientsPathogenic cytokinesLupus erythematosusInterleukin-21
2020
Repeat tick exposure elicits distinct immune responses in guinea pigs and mice
Kurokawa C, Narasimhan S, Vidyarthi A, Booth CJ, Mehta S, Meister L, Diktas H, Strank N, Lynn GE, DePonte K, Craft J, Fikrig E. Repeat tick exposure elicits distinct immune responses in guinea pigs and mice. Ticks And Tick-borne Diseases 2020, 11: 101529. PMID: 32993942, PMCID: PMC7530331, DOI: 10.1016/j.ttbdis.2020.101529.Peer-Reviewed Original ResearchConceptsGuinea pigsElicit distinct immune responsesDistinct immune responsesGuinea pig modelLocal blood flowImmune animalsInflammatory pathwaysTick rejectionMechanisms of resistanceImmune responseMouse modelVaccine candidatesBite siteBlood flowPig modelCoagulation pathwayComplement activationAcquired ResistanceProtective antigenTick detachmentTick proteinsBlood mealMiceTick infestationRNA sequencing
2019
Georgia Abortion Law and Our Commitment to Patients
Craft JE, Crow MK, Lockshin M, Salmon J, Diamond B, Elkon K, Flood J, Fox D, Gabriel S, Gilkeson G, Hahn B, Hardin J, Koopman W, Seaman WE, Wofsy D, Sergent J, Uknis A, Weinblatt M. Georgia Abortion Law and Our Commitment to Patients. Arthritis & Rheumatology 2019, 72: 377-378. PMID: 31637878, DOI: 10.1002/art.41143.Peer-Reviewed Original ResearchDistinct modes of mitochondrial metabolism uncouple T cell differentiation and function
Bailis W, Shyer JA, Zhao J, Canaveras JCG, Al Khazal FJ, Qu R, Steach HR, Bielecki P, Khan O, Jackson R, Kluger Y, Maher LJ, Rabinowitz J, Craft J, Flavell RA. Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function. Nature 2019, 571: 403-407. PMID: 31217581, PMCID: PMC6939459, DOI: 10.1038/s41586-019-1311-3.Peer-Reviewed Original ResearchConceptsMitochondrial citrate exportTerminal effector functionsMalate-aspartate shuttleCitrate exportHistone acetylationCell differentiationComplex ICellular biochemical compositionT cell differentiationSuccinate dehydrogenaseT cell activationExpression of genesElectron transport chainTricarboxylic acid cycleT cell receptor ligationAnabolic programTranscriptional remodellingTranscriptional programmingEpigenetic remodellingSignal transductionCell activationMetabolic reprogrammingCell statesDistinct modesEffector functions
2018
Human Extrafollicular CD4+ Th Cells Help Memory B Cells Produce Igs.
Kim ST, Choi JY, Lainez B, Schulz VP, Karas DE, Baum ED, Setlur J, Gallagher PG, Craft J. Human Extrafollicular CD4+ Th Cells Help Memory B Cells Produce Igs. The Journal Of Immunology 2018, 201: 1359-1372. PMID: 30030323, PMCID: PMC6112860, DOI: 10.4049/jimmunol.1701217.Peer-Reviewed Original ResearchConceptsMemory B cellsHumoral recall responsesB cell folliclesT cell subsetsB cellsTfh cellsCell subsetsRecall responsesT cellsInhibitory receptor PD-1Follicular helper T cellsGerminal center B-cell maturationIL-21 secretionChemokine receptor expressionReceptor PD-1Helper T cellsT cell zonesPrimary immune responseChemokine receptor CXCR5Transcription factor Bcl6B cell maturationTonsillar CD4IL-10IL-21PD-1
2015
Reply
Choi J, Craft J. Reply. Arthritis & Rheumatology 2015, 67: 3094-3095. PMID: 26245163, DOI: 10.1002/art.39290.Peer-Reviewed Original ResearchCirculating Follicular Helper–Like T Cells in Systemic Lupus Erythematosus: Association With Disease Activity
Choi J, Ho J, Pasoto SG, Bunin V, Kim ST, Carrasco S, Borba EF, Gonçalves CR, Costa PR, Kallas EG, Bonfa E, Craft J. Circulating Follicular Helper–Like T Cells in Systemic Lupus Erythematosus: Association With Disease Activity. Arthritis & Rheumatology 2015, 67: 988-999. PMID: 25581113, PMCID: PMC4450082, DOI: 10.1002/art.39020.Peer-Reviewed Original ResearchConceptsTfh-like cellsSLE Disease Activity IndexSystemic lupus erythematosusInducible T-cell costimulatorPD-1 expressionDisease activityT cellsBehçet's diseaseSLE patientsLupus erythematosusBlood samplesT cell-B cell collaborationCentral memory T cellsExpression of CXCR5Disease activity indexGerminal center activityMemory T cellsDeath 1 proteinFollicular helper TT-cell costimulatorActive diseaseAntibody positivityDisease durationFollicular helperIL-21Local Triggering of the ICOS Coreceptor by CD11c+ Myeloid Cells Drives Organ Inflammation in Lupus
Teichmann LL, Cullen JL, Kashgarian M, Dong C, Craft J, Shlomchik MJ. Local Triggering of the ICOS Coreceptor by CD11c+ Myeloid Cells Drives Organ Inflammation in Lupus. Immunity 2015, 42: 552-565. PMID: 25786178, PMCID: PMC4456685, DOI: 10.1016/j.immuni.2015.02.015.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisAutoantibodiesCD11c AntigenCell DifferentiationFemaleGene Expression RegulationHumansInducible T-Cell Co-Stimulator LigandInducible T-Cell Co-Stimulator ProteinKidneyLungLupus NephritisMice, TransgenicPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionT-Lymphocytes, Helper-InducerConceptsInducible T-cell costimulatorOrgan inflammationICOS ligandFollicular helper cell differentiationLupus-prone MRLT-cell costimulatorHelper cell differentiationLupus pathologyLung inflammationAutoantibody formationAutoantibody productionMurine lupusInflamed organsLymphoid tissueT cellsB cellsPathogenic relevanceInflammationLupusPI3K-AktSelective ablationCell differentiationNonredundant rolePotent promoterCells
2013
The nanomaterial-dependent modulation of dendritic cells and its potential influence on therapeutic immunosuppression in lupus
Look M, Saltzman WM, Craft J, Fahmy TM. The nanomaterial-dependent modulation of dendritic cells and its potential influence on therapeutic immunosuppression in lupus. Biomaterials 2013, 35: 1089-1095. PMID: 24183697, PMCID: PMC4164020, DOI: 10.1016/j.biomaterials.2013.10.046.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedDendritic CellsDrug CarriersFemaleImmunosuppression TherapyImmunosuppressive AgentsLactic AcidLupus Erythematosus, SystemicMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred NZBMycophenolic AcidNanogelsPermeabilityPolyethylene GlycolsPolyethyleneiminePolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerConceptsDendritic cellsTherapeutic immunosuppressionLupus-prone NZB/W F1 miceNZB/W F1 miceW F1 miceCell immunosuppressionImmunosuppressive therapyInflammatory cytokinesImmune modulatorsF1 miceImmune responseImmunosuppressionVivo efficacySurface markersMycophenolic acidGreater reductionParticulate uptakeAttractive modalityEfficacyCellsNanoparticulate platformSuccessful deliveryImmunosuppressantsLupusCytokinesNanogel-based delivery of mycophenolic acid ameliorates systemic lupus erythematosus in mice
Look M, Stern E, Wang QA, DiPlacido LD, Kashgarian M, Craft J, Fahmy TM. Nanogel-based delivery of mycophenolic acid ameliorates systemic lupus erythematosus in mice. Journal Of Clinical Investigation 2013, 123: 1741-1749. PMID: 23454752, PMCID: PMC3613921, DOI: 10.1172/jci65907.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusMedian survival timeMycophenolic acidLupus erythematosusImmune cellsLupus-prone NZB/W F1 miceNZB/W F1 miceSimilar therapeutic resultsW F1 miceSevere renal damageCD4 T cellsAntigen-presenting cellsLupus therapyRenal damageIL-12Immunosuppressant mycophenolic acidInflammatory cytokinesProphylactic useTherapeutic resultsF1 miceT cellsSurvival timeGreater dosesErythematosusImmunosuppression
2012
IL-7Rαlow memory CD8+ T cells are significantly elevated in patients with systemic lupus erythematosus
Kim JS, Cho BA, Sim JH, Shah K, Woo CM, Lee EB, Lee DS, Kang JS, Lee WJ, Park CG, Craft J, Kang I, Kim HR. IL-7Rαlow memory CD8+ T cells are significantly elevated in patients with systemic lupus erythematosus. Rheumatology 2012, 51: 1587-1594. PMID: 22661557, PMCID: PMC3418646, DOI: 10.1093/rheumatology/kes100.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntibodies, BlockingAntigens, CDCD8-Positive T-LymphocytesCoculture TechniquesCytotoxicity, ImmunologicFemaleFlow CytometryHumansImmunologic MemoryImmunophenotypingLupus Erythematosus, SystemicLymphocyte CountReceptors, ImmunologicReceptors, Interleukin-7Signaling Lymphocytic Activation Molecule FamilyConceptsEffector memoryFrequency of ILT cellsHealthy individualsHuman effector memoryTarget cellsSystemic lupus erythematosusPathogenesis of lupusSLE patientsMemory CD8Lupus erythematosusNK cellsCytotoxic functionPeripheral bloodDisease manifestationsPatientsCD48 antigenCytotoxic moleculesFlow cytometrySLECell populationsPotential roleLupusILCellular characteristics
2011
IL-10 signaling in CD4+ T cells is critical for the pathogenesis of collagen-induced arthritis
Tao J, Kamanaka M, Hao J, Hao Z, Jiang X, Craft JE, Flavell RA, Wu Z, Hong Z, Zhao L, Yin Z. IL-10 signaling in CD4+ T cells is critical for the pathogenesis of collagen-induced arthritis. Arthritis Research & Therapy 2011, 13: r212. PMID: 22192790, PMCID: PMC3334665, DOI: 10.1186/ar3545.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArthritis, ExperimentalCattleCD4-Positive T-LymphocytesCell ProliferationCollagen Type IIFemaleFlow CytometryForkhead Transcription FactorsInterferon-gammaInterleukin-10Interleukin-17Lymphocyte ActivationMaleMiceMice, Inbred C57BLMice, Inbred DBAMice, TransgenicReceptors, Antigen, T-Cell, gamma-deltaReceptors, Interleukin-10Reverse Transcriptase Polymerase Chain ReactionSignal TransductionT-Lymphocytes, RegulatoryConceptsCollagen-induced arthritisIL-10 signalingIL-17 mRNARegulatory T cellsT cell proliferationT cellsT cell activationSuppressive functionImportant anti-inflammatory cytokineBovine type II collagenAnti-inflammatory cytokinesFunction of TregsAbility of TregsSeverity of arthritisLevels of Foxp3Wild-type miceAntigen-specific antibodiesUnpaired t-testMore IFNControl miceCytokine productionTg miceInflammatory jointsFemale miceArthritic jointsThe Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice
Tang W, Lu Y, Tian QY, Zhang Y, Guo FJ, Liu GY, Syed NM, Lai Y, Lin EA, Kong L, Su J, Yin F, Ding AH, Zanin-Zhorov A, Dustin ML, Tao J, Craft J, Yin Z, Feng JQ, Abramson SB, Yu XP, Liu CJ. The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice. Science 2011, 332: 478-484. PMID: 21393509, PMCID: PMC3104397, DOI: 10.1126/science.1199214.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAnimalsAnti-Inflammatory Agents, Non-SteroidalArthritis, ExperimentalCartilage, ArticularFemaleGranulinsHumansIntercellular Signaling Peptides and ProteinsLigandsMaleMiceMice, Inbred StrainsMice, KnockoutMice, TransgenicMiddle AgedProgranulinsProtein Interaction Domains and MotifsReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IIRecombinant Fusion ProteinsRecombinant ProteinsSignal TransductionT-Lymphocytes, RegulatoryTumor Necrosis Factor-alphaYoung AdultConceptsInflammatory arthritisAdministration of progranulinAntagonist of TNFαCollagen-induced arthritisArthritis mouse modelPGRN-deficient miceNew potential therapeutic interventionsPotential therapeutic interventionsGrowth factor progranulinNecrosis factor receptorRheumatoid arthritisMouse modelArthritisTherapeutic interventionsProgranulinTNF receptorFactor receptorMiceReceptorsInflammationTissue repairTNFαIntracellular signalingAtsttrinTNFR
2010
In Vivo Regulation of Bcl6 and T Follicular Helper Cell Development
Poholek AC, Hansen K, Hernandez SG, Eto D, Chandele A, Weinstein JS, Dong X, Odegard JM, Kaech SM, Dent AL, Crotty S, Craft J. In Vivo Regulation of Bcl6 and T Follicular Helper Cell Development. The Journal Of Immunology 2010, 185: 313-326. PMID: 20519643, PMCID: PMC2891136, DOI: 10.4049/jimmunol.0904023.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CommunicationCell DifferentiationCricetinaeDNA-Binding ProteinsDown-RegulationFemaleImmunophenotypingLymphocyte CooperationMembrane GlycoproteinsMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutMice, TransgenicProto-Oncogene Proteins c-bcl-6SpleenT-Lymphocyte SubsetsT-Lymphocytes, Helper-InducerUp-RegulationConceptsPD-1 upregulationIL-21IL-6B cellsFollicular helper T cellsFollicular helper cell developmentDeath receptor-1Helper T cellsCytokines IL-6B cell interactionsB cell maturationTranscriptional repressor BCL6Vivo regulationCell developmentP-selectin glycoprotein ligand-1New surface markersT cellsGerminal centersInitial upregulationReceptor 1CXCR5BCL6 upregulationCell maturationSurface markersBCL6 expressionDysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus
Shah K, Lee WW, Lee SH, Kim SH, Kang SW, Craft J, Kang I. Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus. Arthritis Research & Therapy 2010, 12: r53. PMID: 20334681, PMCID: PMC2888202, DOI: 10.1186/ar2964.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusSLE Disease Activity Index (SLEDAI) scorePeripheral blood mononuclear cellsTh17-polarizing cytokinesTh1 cell responsesDisease activityT cellsHealthy subjectsIL-17Th1 cellsCell responsesPhorbol myristate acetateTh17 cellsLupus erythematosusIL-6Plasma levelsDisease activity index scoreBalance of CD4Balance of Th17Expression of Th17Th17 cell responseActivity index scoreFrequency of CD4Chemokine receptor CCR4Blood mononuclear cells
2008
Autoantibodies against cyclophilin in systemic lupus erythematosus and Lyme disease
KRATZ A, HARDING MW, CRAFT J, MACKWORTH-YOUNG C, HANDSCHUMACHER RE. Autoantibodies against cyclophilin in systemic lupus erythematosus and Lyme disease. Clinical & Experimental Immunology 2008, 90: 422-427. PMID: 1458678, PMCID: PMC1554566, DOI: 10.1111/j.1365-2249.1992.tb05862.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAmino Acid IsomerasesAntibodies, Anti-IdiotypicAntibodies, MonoclonalAntibody SpecificityAutoantibodiesCarrier ProteinsChildEnzyme-Linked Immunosorbent AssayFamily HealthFemaleHumansImmunoglobulin GImmunoglobulin IdiotypesImmunoglobulin MLupus Erythematosus, SystemicLyme DiseaseMaleMiddle AgedPeptidylprolyl IsomeraseProtein DenaturationConceptsSystemic lupus erythematosusLupus erythematosusFirst-degree relativesLyme disease patientsMonoclonal IgM antibodyLupus patientsIgM antibodiesDisease patientsLepromatous leprosyImmune systemPatientsWestern blotLyme diseaseAntibodiesErythematosusAutoantibodiesHypergammaglobulinaemiaCyclophilinCyclosporinLeprosyDiseaseSerum
2006
Abrogation of skin disease in LUPUS‐prone MRL/FASlpr mice by means of a novel tylophorine analog
Choi J, Gao W, Odegard J, Shiah H, Kashgarian M, McNiff JM, Baker DC, Cheng Y, Craft J. Abrogation of skin disease in LUPUS‐prone MRL/FASlpr mice by means of a novel tylophorine analog. Arthritis & Rheumatism 2006, 54: 3277-3283. PMID: 17009262, DOI: 10.1002/art.22119.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusEnd-organ diseaseInflammatory skin diseaseMRL/Skin diseasesMRL/Faslpr miceFemale MRL/NF-kappaB inhibitorFlow cytometric analysisFaslpr miceAutoantibody titersIgG levelsLupus erythematosusLymph nodesRenal diseaseVehicle treatmentKidney diseaseHepatic toxicityTotal IgMTylophorine analogsAntichromatin autoantibodiesTherapeutic effectHistopathologic analysisMurine modelSignificant abrogation
2004
The Centromeric Region of Chromosome 7 from MRL Mice (Lmb3) Is an Epistatic Modifier of Fas for Autoimmune Disease Expression
Kong PL, Morel L, Croker BP, Craft J. The Centromeric Region of Chromosome 7 from MRL Mice (Lmb3) Is an Epistatic Modifier of Fas for Autoimmune Disease Expression. The Journal Of Immunology 2004, 172: 2785-2794. PMID: 14978078, DOI: 10.4049/jimmunol.172.5.2785.Peer-Reviewed Original ResearchConceptsMRL/Prototypic systemic autoimmune diseaseDouble-negative T cellsAutoimmune disease expressionEtiology of lupusResistant C57BL/6 backgroundLupus-prone miceSystemic autoimmune diseaseFas-deficient miceT cell activationLupus susceptibility lociAutoantibody productionAutoimmune diseasesKidney diseaseT cellsMRL miceAbsence of FasDefective Control of Latent Epstein-Barr Virus Infection in Systemic Lupus Erythematosus
Kang I, Quan T, Nolasco H, Park SH, Hong MS, Crouch J, Pamer EG, Howe JG, Craft J. Defective Control of Latent Epstein-Barr Virus Infection in Systemic Lupus Erythematosus. The Journal Of Immunology 2004, 172: 1287-1294. PMID: 14707107, DOI: 10.4049/jimmunol.172.2.1287.Peer-Reviewed Original ResearchMeSH KeywordsAdultB-Lymphocyte SubsetsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCytomegalovirusEpitopes, T-LymphocyteEpstein-Barr Virus InfectionsFemaleHerpesvirus 4, HumanHumansLeukocytes, MononuclearLupus Erythematosus, SystemicLymphocyte CountMaleMiddle AgedSeverity of Illness IndexViral LoadVirus LatencyConceptsSystemic lupus erythematosusEBV viral loadT cell responsesViral loadT cellsIFN-gammaCell responsesEBV infectionLupus erythematosusHealthy controlsEBV-specific T-cell responsesVirus-specific T cell responsesLatent Epstein-Barr virus (EBV) infectionEBV-specific immune responsesEpstein-Barr virus infectionAltered T-cell responsesDefective controlFrequency of CD69HLA-A2 tetramersTetramer-positive CD8Latent EBV infectionEBV-specificImmunosuppressive medicationsDisease activityLupus patients
2003
IFN-γ-Producing γδ T Cells Help Control Murine West Nile Virus Infection
Wang T, Scully E, Yin Z, Kim JH, Wang S, Yan J, Mamula M, Anderson JF, Craft J, Fikrig E. IFN-γ-Producing γδ T Cells Help Control Murine West Nile Virus Infection. The Journal Of Immunology 2003, 171: 2524-2531. PMID: 12928402, DOI: 10.4049/jimmunol.171.5.2524.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsBloodCell DivisionCells, CulturedCytotoxicity, ImmunologicEncephalitis, ViralFemaleGenes, T-Cell Receptor betaGenes, T-Cell Receptor deltaGenetic Predisposition to DiseaseInterferon-gammaLymphoid TissueMiceMice, Inbred C57BLMice, KnockoutReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaSeverity of Illness IndexT-Lymphocyte SubsetsViral LoadWest Nile FeverWest Nile virusConceptsGammadelta T cellsWN virus infectionT cellsVirus infectionIFN-gamma-producing gammadelta T cellsWest Nile virus infectionPrevention of mortalityΓδ T cellsSplenic T cellsWild-type miceEx vivo assaysAdoptive transferWest Nile virusPerforin expressionViral loadFatal meningoencephalitisIFN-gammaMiceInfectionWN virusNile virusVivo assaysLaboratory miceCellsVirus