2019
Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function
Bailis W, Shyer JA, Zhao J, Canaveras JCG, Al Khazal FJ, Qu R, Steach HR, Bielecki P, Khan O, Jackson R, Kluger Y, Maher LJ, Rabinowitz J, Craft J, Flavell RA. Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function. Nature 2019, 571: 403-407. PMID: 31217581, PMCID: PMC6939459, DOI: 10.1038/s41586-019-1311-3.Peer-Reviewed Original ResearchConceptsMitochondrial citrate exportTerminal effector functionsMalate-aspartate shuttleCitrate exportHistone acetylationCell differentiationComplex ICellular biochemical compositionT cell differentiationSuccinate dehydrogenaseT cell activationExpression of genesElectron transport chainTricarboxylic acid cycleT cell receptor ligationAnabolic programTranscriptional remodellingTranscriptional programmingEpigenetic remodellingSignal transductionCell activationMetabolic reprogrammingCell statesDistinct modesEffector functions
1987
Autoantigenic histone epitopes: a comparison between procainamide‐ and hydralazine‐induced lupus
Craft J, Radding J, Harding M, Bernstein R, Hardin J. Autoantigenic histone epitopes: a comparison between procainamide‐ and hydralazine‐induced lupus. Arthritis & Rheumatism 1987, 30: 689-694. PMID: 2440452, DOI: 10.1002/art.1780300612.Peer-Reviewed Original ResearchConceptsHydralazine-induced lupusSpontaneous systemic lupus erythematosusDrug-induced lupusSystemic lupus erythematosusAbility of serumProcainamide-induced lupusHistone epitopesLupus erythematosusAntihistone antibodiesLupusTechnique of immunoblottingPatientsIndividual histonesSerumEpitopesHistone fragmentsDifferent mechanismsErythematosusProcainamideAntibodies