2018
Human Extrafollicular CD4+ Th Cells Help Memory B Cells Produce Igs.
Kim ST, Choi JY, Lainez B, Schulz VP, Karas DE, Baum ED, Setlur J, Gallagher PG, Craft J. Human Extrafollicular CD4+ Th Cells Help Memory B Cells Produce Igs. The Journal Of Immunology 2018, 201: 1359-1372. PMID: 30030323, PMCID: PMC6112860, DOI: 10.4049/jimmunol.1701217.Peer-Reviewed Original ResearchConceptsMemory B cellsHumoral recall responsesB cell folliclesT cell subsetsB cellsTfh cellsCell subsetsRecall responsesT cellsInhibitory receptor PD-1Follicular helper T cellsGerminal center B-cell maturationIL-21 secretionChemokine receptor expressionReceptor PD-1Helper T cellsT cell zonesPrimary immune responseChemokine receptor CXCR5Transcription factor Bcl6B cell maturationTonsillar CD4IL-10IL-21PD-1
2008
ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity
Odegard JM, Marks BR, DiPlacido LD, Poholek AC, Kono DH, Dong C, Flavell RA, Craft J. ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity. Journal Of Experimental Medicine 2008, 205: 2873-2886. PMID: 18981236, PMCID: PMC2585848, DOI: 10.1084/jem.20080840.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteAutoimmunityCell DifferentiationChemokinesDisease Models, AnimalGerminal CenterImmunoglobulin Class SwitchingImmunoglobulin GInducible T-Cell Co-Stimulator ProteinInterleukinsLupus Erythematosus, SystemicMembrane GlycoproteinsMiceMice, KnockoutPlasma CellsReceptors, CXCR4T-Lymphocyte SubsetsT-Lymphocytes, Helper-InducerConceptsEffector T cellsT cellsIL-21IgG productionCXC chemokine receptor 4 (CXCR4) expressionB cell helper functionFollicular helper T cellsChemokine receptor 4 expressionReceptor 4 expressionCD4 T cellsHelper T cellsMRL/MpJAutoimmune strainsP-selectin glycoprotein ligand-1Autoantibody productionChronic autoimmunitySystemic autoimmunityPlasma cellsExtrafollicular responseExtrafollicular sitesMouse modelGerminal centersHelper functionSelective lossLigand 1Autoantibodies against cyclophilin in systemic lupus erythematosus and Lyme disease
KRATZ A, HARDING MW, CRAFT J, MACKWORTH-YOUNG C, HANDSCHUMACHER RE. Autoantibodies against cyclophilin in systemic lupus erythematosus and Lyme disease. Clinical & Experimental Immunology 2008, 90: 422-427. PMID: 1458678, PMCID: PMC1554566, DOI: 10.1111/j.1365-2249.1992.tb05862.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAmino Acid IsomerasesAntibodies, Anti-IdiotypicAntibodies, MonoclonalAntibody SpecificityAutoantibodiesCarrier ProteinsChildEnzyme-Linked Immunosorbent AssayFamily HealthFemaleHumansImmunoglobulin GImmunoglobulin IdiotypesImmunoglobulin MLupus Erythematosus, SystemicLyme DiseaseMaleMiddle AgedPeptidylprolyl IsomeraseProtein DenaturationConceptsSystemic lupus erythematosusLupus erythematosusFirst-degree relativesLyme disease patientsMonoclonal IgM antibodyLupus patientsIgM antibodiesDisease patientsLepromatous leprosyImmune systemPatientsWestern blotLyme diseaseAntibodiesErythematosusAutoantibodiesHypergammaglobulinaemiaCyclophilinCyclosporinLeprosyDiseaseSerum
2006
Abrogation of skin disease in LUPUS‐prone MRL/FASlpr mice by means of a novel tylophorine analog
Choi J, Gao W, Odegard J, Shiah H, Kashgarian M, McNiff JM, Baker DC, Cheng Y, Craft J. Abrogation of skin disease in LUPUS‐prone MRL/FASlpr mice by means of a novel tylophorine analog. Arthritis & Rheumatism 2006, 54: 3277-3283. PMID: 17009262, DOI: 10.1002/art.22119.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusEnd-organ diseaseInflammatory skin diseaseMRL/Skin diseasesMRL/Faslpr miceFemale MRL/NF-kappaB inhibitorFlow cytometric analysisFaslpr miceAutoantibody titersIgG levelsLupus erythematosusLymph nodesRenal diseaseVehicle treatmentKidney diseaseHepatic toxicityTotal IgMTylophorine analogsAntichromatin autoantibodiesTherapeutic effectHistopathologic analysisMurine modelSignificant abrogationγδ T Cells Facilitate Adaptive Immunity against West Nile Virus Infection in Mice
Wang T, Gao Y, Scully E, Davis CT, Anderson JF, Welte T, Ledizet M, Koski R, Madri JA, Barrett A, Yin Z, Craft J, Fikrig E. γδ T Cells Facilitate Adaptive Immunity against West Nile Virus Infection in Mice. The Journal Of Immunology 2006, 177: 1825-1832. PMID: 16849493, DOI: 10.4049/jimmunol.177.3.1825.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsCD8-Positive T-LymphocytesGenetic Predisposition to DiseaseImmunity, CellularImmunity, InnateImmunization, SecondaryImmunoglobulin GImmunoglobulin MImmunologic MemoryLymphocyte DepletionMiceMice, Inbred C57BLMice, KnockoutReceptors, Antigen, T-Cell, gamma-deltaRecurrenceT-Lymphocyte SubsetsWest Nile FeverWest Nile virusConceptsGammadelta T cellsWild-type miceT cellsWN virus infectionPrimary infectionVirus infectionWN virusNaive miceSecondary challengeImmune responseAdaptive immunityCD8 memory T cellsWest Nile virus infectionMemory T cellsProtective immune responseAdaptive immune responsesAdoptive transferWest Nile virusAb responsesLethal infectionViral challengeFatal meningoencephalitisSecondary infectionInfectionMice
1996
Autoimmune lpr/lpr mice deficient in CD40 ligand: spontaneous Ig class switching with dichotomy of autoantibody responses.
Ma J, Xu J, Madaio MP, Peng Q, Zhang J, Grewal IS, Flavell RA, Craft J. Autoimmune lpr/lpr mice deficient in CD40 ligand: spontaneous Ig class switching with dichotomy of autoantibody responses. The Journal Of Immunology 1996, 157: 417-26. PMID: 8683147, DOI: 10.4049/jimmunol.157.1.417.Peer-Reviewed Original ResearchConceptsLpr/lpr miceLpr miceIgG autoantibodiesAutoantibody responseCD40 ligandAutoimmune lpr/lpr miceMRL/Mp-lpr/lpr miceHuman systemic lupus erythematosusSystemic lupus erythematosusAge 3 moIgG rheumatoid factorB cell contactSubset of animalsOvert glomerulonephritisLupus erythematosusIgG2b levelsHistologic evidenceRheumatoid factorSerum IgMAb synthesisAutoantibodiesLpr animalsMiceIg classesElevated levelsGerminal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells.
Wen L, Pao W, Wong FS, Peng Q, Craft J, Zheng B, Kelsoe G, Dianda L, Owen MJ, Hayday AC. Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells. Journal Of Experimental Medicine 1996, 183: 2271-2282. PMID: 8642336, PMCID: PMC2192585, DOI: 10.1084/jem.183.5.2271.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantibodiesClone CellsFlow CytometryGerminal CenterHumansImmunoglobulin Class SwitchingImmunoglobulin EImmunoglobulin GLupus Erythematosus, SystemicLymphocyte DepletionMiceMice, Inbred NODMice, Inbred StrainsMice, KnockoutMice, SCIDReceptors, Antigen, T-Cell, alpha-betaSpleenT-LymphocytesConceptsSystemic lupus erythematosusBeta T cellsAlpha/beta T cellsGamma/delta T cellsDelta T cellsT cell helpT cellsT cell receptorCell helpT cell-mediated conditionsHuman systemic lupus erythematosusSevere combined immunodeficient (SCID) miceDevelopment of autoantibodiesCombined Immunodeficient MiceT-cell immunodeficiencyClass-switched antibodiesB cell collaborationGerminal center formationLupus erythematosusAutoantibody productionLymphoid folliclesImmunoglobulin class switchingIgE synthesisAlpha/betaCell immunodeficiency
1995
Safety and Immunogenicity of an Outer Surface Protein A Vaccine in Subjects with Previous Lyme Disease
Schoen R, Meurice F, Brunet C, Cretella S, Krause D, Craft J, Fikrig E. Safety and Immunogenicity of an Outer Surface Protein A Vaccine in Subjects with Previous Lyme Disease. The Journal Of Infectious Diseases 1995, 172: 1324-1329. PMID: 7594671, DOI: 10.1093/infdis/172.5.1324.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntibodies, BacterialAntibody FormationAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial VaccinesBorrelia burgdorferi GroupDose-Response Relationship, DrugEnzyme-Linked Immunosorbent AssayHumansImmunization ScheduleImmunoglobulin GLipoproteinsLyme DiseaseProspective StudiesSafetyVaccines, SyntheticConceptsSide effectsLyme diseaseOspA vaccinePrevious Lyme diseaseThree-dose scheduleLocal side effectsSystemic side effectsLyme vaccineMild arthralgiaVaccine doseThird doseProspective studyOspA antibodiesHealthy volunteersOuter surface proteinsVaccinePatientsDiseaseImmunogenicityDoseMonthsSubjectsSurface proteinsSafetyArthralgia
1994
Pattern of anti-small nuclear ribonucleoprotein antibodies in MRL/Mp-lpr/lpr mice suggests that the intact U1 snRNP particle is their autoimmunogenic target.
Fatenejad S, Brooks W, Schwartz A, Craft J. Pattern of anti-small nuclear ribonucleoprotein antibodies in MRL/Mp-lpr/lpr mice suggests that the intact U1 snRNP particle is their autoimmunogenic target. The Journal Of Immunology 1994, 152: 5523-31. PMID: 7514640, DOI: 10.4049/jimmunol.152.11.5523.Peer-Reviewed Original ResearchConceptsMRL/lpr miceMRL/Mp-lpr/lpr miceLpr miceAnti-Sm AbsHuman SLEAnti-Sm responseRibonucleoprotein antibodiesNormal miceImmune responseMiceSLEEarly AbsSimilar epitopesD proteinsSerumHuman serumEpitopesU1 snRNP particleFrequent responsePrevious findingsAbResponseSnRNP particlesHumansPrevious observationsImmunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in αβ(+) T cells
Wen L, Roberts S, Viney J, Wong F, Mallick C, Findly R, Peng Q, Craft J, Owen M, Mayday A. Immunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in αβ(+) T cells. Nature 1994, 369: 654-658. PMID: 8208291, DOI: 10.1038/369654a0.Peer-Reviewed Original ResearchConceptsΑβ T cellsT cellsT cell antigen receptorB cell-T cell interactionsHelp of CD4Provision of cytokinesB cell hyperactivitySystemic lupus erythematosusCognate B cell-T cell interactionT cell functionGeneralized autoimmunityLupus erythematosusTransplant rejectionIgE secretionImmunoglobulin synthesisB cellsIgG3 secretionAntigen receptorCD4AutoimmunityMiceSecretionAntibodiesCellsErythematosus
1986
Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness.
Craft JE, Fischer DK, Shimamoto GT, Steere AC. Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness. Journal Of Clinical Investigation 1986, 78: 934-939. PMID: 3531237, PMCID: PMC423723, DOI: 10.1172/jci112683.Peer-Reviewed Original ResearchMeSH KeywordsAntibody FormationAntigensBorreliaHumansImmunoglobulin GImmunoglobulin MImmunosorbent TechniquesLyme DiseaseMolecular WeightConceptsIgG responsesIgM responseEarly diseaseLyme diseaseImmunoglobulin M responseImmunoglobulin G responseBorrelia burgdorferiSpirochetal antigensG responsesIgG antibodiesProlonged illnessPatientsM responseIllnessDiseaseAntigenB. burgdorferiMonthsLimited responseIgMBurgdorferiSuch responsesResponseArthritisYears
1984
Antibody Response in Lyme Disease: Evaluation of Diagnostic Tests
Craft J, Grodzicki R, Steere A. Antibody Response in Lyme Disease: Evaluation of Diagnostic Tests. The Journal Of Infectious Diseases 1984, 149: 789-795. PMID: 6373966, DOI: 10.1093/infdis/149.5.789.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayAntibody responseLyme diseaseIgM antibodiesAntibody titersSpecific IgM antibody titersDiagnostic testsSpecific IgG antibody titersIgG antibody titersIgM antibody titersSerial serum samplesSpecific IgM antibodiesMonths of remissionCross-reactive antibodiesIxodes dammini spirocheteBetter diagnostic testsTiters of seraEarly diseaseControl subjectsAdsorption of serumPatientsSuch titersHigh titersDiseaseSerum samplesThe antibody response in Lyme disease.
Craft JE, Grodzicki RL, Shrestha M, Fischer DK, García-Blanco M, Steere AC. The antibody response in Lyme disease. The Yale Journal Of Biology And Medicine 1984, 57: 561-5. PMID: 6393607, PMCID: PMC2590019.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayHumoral immune responseAntibody responseImmune responseIndirect immunofluorescenceLyme diseaseI. dammini spirocheteLyme arthritis patientsSpecific IgG responseSpecific IgM responseMonths of remissionSpecific IgM levelsIxodes dammini spirocheteLyme disease seraCross-reactive antibodiesTotal serum IgM.Lyme disease patientsAbsorption of seraArthritis patientsLyme arthritisIgG responsesIgM responseIgM levelsSpirochetal antigensDisease patients