2021
Type I Interferon–Activated STAT4 Regulation of Follicular Helper T Cell–Dependent Cytokine and Immunoglobulin Production in Lupus
Dong X, Antao OQ, Song W, Sanchez GM, Zembrzuski K, Koumpouras F, Lemenze A, Craft J, Weinstein JS. Type I Interferon–Activated STAT4 Regulation of Follicular Helper T Cell–Dependent Cytokine and Immunoglobulin Production in Lupus. Arthritis & Rheumatology 2021, 73: 478-489. PMID: 33512094, PMCID: PMC7914134, DOI: 10.1002/art.41532.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntibody FormationAutoantibodiesB-LymphocytesCase-Control StudiesCytokinesDisease Models, AnimalFemaleHumansImmunoglobulinsInterferon Type IInterferon-gammaInterleukinsLupus Erythematosus, SystemicMaleMice, Inbred MRL lprMiddle AgedRNA-SeqSTAT4 Transcription FactorT Follicular Helper CellsConceptsSystemic lupus erythematosusTfh-like cellsTfh cellsIL-21Human lupusDisease activityCytokine productionSTAT4 activationImmunoglobulin productionPathogenic B cell responsesCourse of lupusClinical disease activityT cell secretionLupus-prone miceHealthy control subjectsCourse of diseaseB cell responsesCytokine interleukin-21Potential therapeutic targetType I IFNB cell maturationSLE patientsPathogenic cytokinesLupus erythematosusInterleukin-21
2017
STAT4 and T-bet control follicular helper T cell development in viral infections
Weinstein JS, Laidlaw BJ, Lu Y, Wang JK, Schulz VP, Li N, Herman EI, Kaech SM, Gallagher PG, Craft J. STAT4 and T-bet control follicular helper T cell development in viral infections. Journal Of Experimental Medicine 2017, 215: 337-355. PMID: 29212666, PMCID: PMC5748849, DOI: 10.1084/jem.20170457.Peer-Reviewed Original ResearchConceptsIL-21Tfh cellsT-betViral infectionFollicular helper T cellsHelper T cell developmentAcute viral infectionIFN-γ productionHelper T cellsGerminal center B cell survivalB cell survivalT cell developmentIL-4Viral challengeIL-9T cellsImmunoglobulin isotypesIFNSoluble factorsGC responseInfectionGC reactionSTAT4BCL6Cell survival
2014
CD4+ T Cell Help Guides Formation of CD103+ Lung-Resident Memory CD8+ T Cells during Influenza Viral Infection
Laidlaw BJ, Zhang N, Marshall HD, Staron MM, Guan T, Hu Y, Cauley LS, Craft J, Kaech SM. CD4+ T Cell Help Guides Formation of CD103+ Lung-Resident Memory CD8+ T Cells during Influenza Viral Infection. Immunity 2014, 41: 633-645. PMID: 25308332, PMCID: PMC4324721, DOI: 10.1016/j.immuni.2014.09.007.Peer-Reviewed Original ResearchConceptsT cellsTRM cellsT-betTissue-resident memory T cellsLung-resident memory CD8T cell-dependent signalsT cell-derived interferonTranscription factor T-betLung Trm cellsMemory T cellsInfluenza viral infectionInfluenza virus infectionT cell helpHeterosubtypic challengeCD103 expressionMemory CD8Respiratory infectionsMucosal sitesCell helpAirway epitheliumVirus infectionViral infectionInfectionLung airwaysImpaired ability
2012
IL-21 Receptor Is Required for the Systemic Accumulation of Activated B and T Lymphocytes in MRL/MpJ-Faslpr/lpr/J Mice
Rankin AL, Guay H, Herber D, Bertino SA, Duzanski TA, Carrier Y, Keegan S, Senices M, Stedman N, Ryan M, Bloom L, Medley Q, Collins M, Nickerson-Nutter C, Craft J, Young D, Dunussi-Joannopoulos K. IL-21 Receptor Is Required for the Systemic Accumulation of Activated B and T Lymphocytes in MRL/MpJ-Faslpr/lpr/J Mice. The Journal Of Immunology 2012, 188: 1656-1667. PMID: 22231702, PMCID: PMC3618484, DOI: 10.4049/jimmunol.1003871.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantibodiesAutoimmunityB-LymphocytesCD4-Positive T-LymphocytesCell DifferentiationInterferon-gammaInterleukinsLupus Erythematosus, SystemicLymphatic DiseasesLymphocyte ActivationMiceMice, Inbred MRL lprMice, KnockoutReceptors, Interleukin-21SkinSplenomegalyT-Lymphocyte SubsetsT-Lymphocytes, Helper-InducerConceptsT cell effector subsetsIL-21Effector subsetsIL-21RT cellsHelper cellsSpontaneous germinal center formationIL-21-dependent mannerIL-21 receptorMRL/MpJPlasma cell accumulationGerminal center formationTh cell differentiationSignificant reductionAutoantibody titersAutoantibody productionCytokines IFNImmune activationSystemic autoimmunityJ miceDisease manifestationsT lymphocytesPleiotropic cytokineB cellsDisease pathogenesis
2011
IL-10 signaling in CD4+ T cells is critical for the pathogenesis of collagen-induced arthritis
Tao J, Kamanaka M, Hao J, Hao Z, Jiang X, Craft JE, Flavell RA, Wu Z, Hong Z, Zhao L, Yin Z. IL-10 signaling in CD4+ T cells is critical for the pathogenesis of collagen-induced arthritis. Arthritis Research & Therapy 2011, 13: r212. PMID: 22192790, PMCID: PMC3334665, DOI: 10.1186/ar3545.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArthritis, ExperimentalCattleCD4-Positive T-LymphocytesCell ProliferationCollagen Type IIFemaleFlow CytometryForkhead Transcription FactorsInterferon-gammaInterleukin-10Interleukin-17Lymphocyte ActivationMaleMiceMice, Inbred C57BLMice, Inbred DBAMice, TransgenicReceptors, Antigen, T-Cell, gamma-deltaReceptors, Interleukin-10Reverse Transcriptase Polymerase Chain ReactionSignal TransductionT-Lymphocytes, RegulatoryConceptsCollagen-induced arthritisIL-10 signalingIL-17 mRNARegulatory T cellsT cell proliferationT cellsT cell activationSuppressive functionImportant anti-inflammatory cytokineBovine type II collagenAnti-inflammatory cytokinesFunction of TregsAbility of TregsSeverity of arthritisLevels of Foxp3Wild-type miceAntigen-specific antibodiesUnpaired t-testMore IFNControl miceCytokine productionTg miceInflammatory jointsFemale miceArthritic joints
2010
Naturally Activated Vγ4 γδ T Cells Play a Protective Role in Tumor Immunity through Expression of Eomesodermin
He W, Hao J, Dong S, Gao Y, Tao J, Chi H, Flavell R, O’Brien R, Born WK, Craft J, Han J, Wang P, Zhao L, Wu J, Yin Z. Naturally Activated Vγ4 γδ T Cells Play a Protective Role in Tumor Immunity through Expression of Eomesodermin. The Journal Of Immunology 2010, 185: 126-133. PMID: 20525896, PMCID: PMC3813958, DOI: 10.4049/jimmunol.0903767.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCell Line, TumorCoculture TechniquesCytotoxicity, ImmunologicHyaluronan ReceptorsInterferon-gammaLymphocyte ActivationMelanoma, ExperimentalMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicPerforinReceptors, Antigen, T-Cell, gamma-deltaT-Box Domain ProteinsT-Lymphocyte SubsetsUp-RegulationConceptsGammadelta T cellsAntitumor immune responseT cellsImmune responseIFN-gammaTumor immunityProtective roleVγ4 γδ T cellsTumor immune surveillanceΓδ T cellsIFN-gamma secretionTumor immune therapyMore IFN-gammaGreater cytolytic activityExpression of EomesoderminAntitumor responseImmune therapyImmune surveillanceCytolytic activityEffector functionsPrincipal subsetsVgamma4Vgamma1Precise rolePerforin
2007
Epigenetic and Transcriptional Programs Lead to Default IFN-γ Production by γδ T Cells
Chen L, He W, Kim ST, Tao J, Gao Y, Chi H, Intlekofer AM, Harvey B, Reiner SL, Yin Z, Flavell RA, Craft J. Epigenetic and Transcriptional Programs Lead to Default IFN-γ Production by γδ T Cells. The Journal Of Immunology 2007, 178: 2730-2736. PMID: 17312115, DOI: 10.4049/jimmunol.178.5.2730.Peer-Reviewed Original Research
2006
Gamma Interferon Plays a Crucial Early Antiviral Role in Protection against West Nile Virus Infection
Shrestha B, Wang T, Samuel MA, Whitby K, Craft J, Fikrig E, Diamond MS. Gamma Interferon Plays a Crucial Early Antiviral Role in Protection against West Nile Virus Infection. Journal Of Virology 2006, 80: 5338-5348. PMID: 16699014, PMCID: PMC1472130, DOI: 10.1128/jvi.00274-06.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntiviral AgentsInterferon-gammaMiceMice, Inbred C57BLWest Nile FeverWest Nile virusConceptsWest Nile virusGammadelta T cellsIFN-gammaLymphoid tissueT cellsWNV infectionProtective roleSevere central nervous system infectionsCentral nervous system infectionWest Nile virus infectionGreater viral replicationNervous system infectionInfectious West Nile virusLethal WNV infectionPeripheral lymphoid tissuesIFN-gamma productionAlpha/beta interferonBone marrow reconstitution experimentsInnate immune response elementsDominant protective rolePrimary dendritic cellsAverage survival timeImmune response elementsEssential protective roleHigh viremia
2004
Age-Associated Change in the Frequency of Memory CD4+ T Cells Impairs Long Term CD4+ T Cell Responses to Influenza Vaccine
Kang I, Hong MS, Nolasco H, Park SH, Dan JM, Choi JY, Craft J. Age-Associated Change in the Frequency of Memory CD4+ T Cells Impairs Long Term CD4+ T Cell Responses to Influenza Vaccine. The Journal Of Immunology 2004, 173: 673-681. PMID: 15210831, DOI: 10.4049/jimmunol.173.1.673.Peer-Reviewed Original ResearchConceptsT cell responsesIL-7 levelsMemory CD4Long-term CD4T cellsCell responsesInfluenza vaccineIFN-gammaInfluenza virus-specific CD4Serum IL-7 levelsEM cellsLevels of CD4Virus-specific CD4Central memory CD4Effector memory CD4Cellular immune responsesFrequency of influenzaImportant clinical questionsAge-Associated ChangesEM CD4Influenza vaccinationTNF-alphaVaccination strategiesIL-7Immune response
2003
IFN-γ-Producing γδ T Cells Help Control Murine West Nile Virus Infection
Wang T, Scully E, Yin Z, Kim JH, Wang S, Yan J, Mamula M, Anderson JF, Craft J, Fikrig E. IFN-γ-Producing γδ T Cells Help Control Murine West Nile Virus Infection. The Journal Of Immunology 2003, 171: 2524-2531. PMID: 12928402, DOI: 10.4049/jimmunol.171.5.2524.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsBloodCell DivisionCells, CulturedCytotoxicity, ImmunologicEncephalitis, ViralFemaleGenes, T-Cell Receptor betaGenes, T-Cell Receptor deltaGenetic Predisposition to DiseaseInterferon-gammaLymphoid TissueMiceMice, Inbred C57BLMice, KnockoutReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaSeverity of Illness IndexT-Lymphocyte SubsetsViral LoadWest Nile FeverWest Nile virusConceptsGammadelta T cellsWN virus infectionT cellsVirus infectionIFN-gamma-producing gammadelta T cellsWest Nile virus infectionPrevention of mortalityΓδ T cellsSplenic T cellsWild-type miceEx vivo assaysAdoptive transferWest Nile virusPerforin expressionViral loadFatal meningoencephalitisIFN-gammaMiceInfectionWN virusNile virusVivo assaysLaboratory miceCellsVirusγδ T Cells Provide an Early Source of Interferon γ in Tumor Immunity
Gao Y, Yang W, Pan M, Scully E, Girardi M, Augenlicht LH, Craft J, Yin Z. γδ T Cells Provide an Early Source of Interferon γ in Tumor Immunity. Journal Of Experimental Medicine 2003, 198: 433-442. PMID: 12900519, PMCID: PMC2194096, DOI: 10.1084/jem.20030584.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsImmunity, CellularInterferon-gammaInterleukin-12Lymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutNeoplasm TransplantationNeoplasms, ExperimentalReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocyte SubsetsTransplantation ChimeraTumor Cells, CulturedConceptsGammadelta T cellsAlphabeta T cellsT cellsTumor immunityIFN-gammaHigh incidenceGammadelta T cell-deficient miceImpaired IFN-gamma productionT cell-deficient miceTumor developmentCell-deficient miceBone marrow chimerasΓδ T cellsIFN-gamma productionSite of tumorT cell repertoireWild-type miceChemical carcinogen methylcholanthreneMelanoma cell line B16B16 melanoma cellsTumor lysateCarcinogen methylcholanthreneTumor immunosurveillanceInterferon γSuch mice
2002
IL-10 Regulates Murine Lupus
Yin Z, Bahtiyar G, Zhang N, Liu L, Zhu P, Robert ME, McNiff J, Madaio MP, Craft J. IL-10 Regulates Murine Lupus. The Journal Of Immunology 2002, 169: 2148-2155. PMID: 12165544, DOI: 10.4049/jimmunol.169.4.2148.Peer-Reviewed Original ResearchConceptsIL-10Murine lupusHuman systemic lupus erythematosusAnti-dsDNA autoantibody productionSeverity of lupusTh1 cytokine responseAnti-dsDNA autoantibodiesSystemic lupus erythematosusIFN-gamma productionIL-10 locusMRL/MpJPotential therapeutic benefitLupus syndromeSevere glomerulonephritisSevere lupusLupus modelsLupus erythematosusRIL-10Autoantibody productionCytokine responsesHuman lupusSerum concentrationsProtective effectSkin lesionsLittermate controlsT-Bet Expression and Failure of GATA-3 Cross-Regulation Lead to Default Production of IFN-γ by γδ T Cells
Yin Z, Chen C, Szabo SJ, Glimcher LH, Ray A, Craft J. T-Bet Expression and Failure of GATA-3 Cross-Regulation Lead to Default Production of IFN-γ by γδ T Cells. The Journal Of Immunology 2002, 168: 1566-1571. PMID: 11823483, DOI: 10.4049/jimmunol.168.4.1566.Peer-Reviewed Original ResearchAnimalsCells, CulturedDNA-Binding ProteinsFlow CytometryGATA3 Transcription FactorInterferon-gammaInterleukin-12Interleukin-4Lymphocyte ActivationMiceMice, Inbred C57BLMicroscopy, ConfocalReceptors, Antigen, T-Cell, gamma-deltaRNA, MessengerT-Box Domain ProteinsT-LymphocytesTrans-ActivatorsTranscription FactorsTranscriptional ActivationTransfection
2000
Dominance of IL-12 Over IL-4 in γδ T Cell Differentiation Leads to Default Production of IFN-γ: Failure to Down-Regulate IL-12 Receptor β2-Chain Expression
Yin Z, Zhang D, Welte T, Bahtiyar G, Jung S, Liu L, Fu X, Ray A, Craft J. Dominance of IL-12 Over IL-4 in γδ T Cell Differentiation Leads to Default Production of IFN-γ: Failure to Down-Regulate IL-12 Receptor β2-Chain Expression. The Journal Of Immunology 2000, 164: 3056-3064. PMID: 10706694, DOI: 10.4049/jimmunol.164.6.3056.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCells, CulturedCytokinesDNA-Binding ProteinsDown-RegulationGATA3 Transcription FactorInterferon-gammaInterleukin-12Interleukin-4Lymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C57BLReceptors, Antigen, T-Cell, gamma-deltaReceptors, InterleukinReceptors, Interleukin-12Signal TransductionSTAT3 Transcription FactorSTAT4 Transcription FactorTh1 CellsTh2 CellsT-Lymphocyte SubsetsTrans-ActivatorsConceptsGamma delta T cellsDelta T cellsT cellsIFN-gammaIL-12IL-4Murine gamma delta T cellsSplenic gamma delta T cellsAlpha beta T cellsIFN-gamma-producing cellsΓδ T-cell differentiationIL-4-secreting cellsBeta T cellsTh2-like cytokinesIL-12 receptorTranscription factor GATA-3T cell differentiationTumor immunityTh1 cellsTh2 cellsSuch cytokinesFinding independentReceptor betaGATA-3Intracellular pathogens
1997
Roles of interferon-gamma and interleukin-4 in murine lupus.
Peng SL, Moslehi J, Craft J. Roles of interferon-gamma and interleukin-4 in murine lupus. Journal Of Clinical Investigation 1997, 99: 1936-1946. PMID: 9109438, PMCID: PMC508018, DOI: 10.1172/jci119361.Peer-Reviewed Original ResearchConceptsEnd-organ diseaseAutoantibody productionMurine lupusIFN-gammaSerum immunoglobulinsMRL/Mp-lpr/lpr micePathogenic autoantibody productionTiters of IgG2aDevelopment of lupusSystemic autoimmune syndromeAlphabeta T cellsLess IgG1Prototypical Th1Autoimmune syndromeLpr miceProne miceTh2 cytokinesIL-4Comparable levelsTissue injuryT cellsInterleukin-4Critical cytokineLupusLymphadenopathy