2012
Follicular helper T cells in immunity and systemic autoimmunity
Craft JE. Follicular helper T cells in immunity and systemic autoimmunity. Nature Reviews Rheumatology 2012, 8: 337-347. PMID: 22549246, PMCID: PMC3604997, DOI: 10.1038/nrrheum.2012.58.Peer-Reviewed Original ResearchConceptsFollicular helper T cellsHelper T cellsT cellsSelf-reactive B cell clonesT helper cell populationSystemic lupus erythematosusSystemic autoimmune diseaseNormal immune responseT cell helpB cell clonesB cell survivalLupus erythematosusAutoantibody productionAutoimmune diseasesSystemic autoimmunityImmune responseAutoimmunityKey regulatorErythematosusCellsDiseaseImmunity
2003
Oxazolone and diclofenac-induced popliteal lymph node assay reactions are attenuated in mice orally pretreated with the respective compound: potential role for the induction of regulatory mechanisms following enteric administration☆
Gutting BW, Bouzahzah F, Kong PL, Updyke LW, Amacher DE, Craft J. Oxazolone and diclofenac-induced popliteal lymph node assay reactions are attenuated in mice orally pretreated with the respective compound: potential role for the induction of regulatory mechanisms following enteric administration☆. Toxicology And Applied Pharmacology 2003, 189: 120-133. PMID: 12781630, DOI: 10.1016/s0041-008x(03)00091-7.Peer-Reviewed Original ResearchConceptsPopliteal lymph node assayPLN reactionDose-dependent increaseNaive micePLN T cellsT cellsOral toleranceFootpad injectionNaive BALB/c miceBALB/c miceContact sensitizer oxazoloneAdoptive transfer studiesDrug hypersensitivity reactionsLymph node assayEnteric administrationOral pretreatmentHypersensitivity reactionsPopliteal lymphC miceUnfractionated splenocytesNSAID diclofenacB cellsRespective drugsSplenocytesPreclinical assays
1995
T cells with gamma/delta T cell receptors (TCR) of intestinal type are preferentially expanded in TCR-alpha-deficient lpr mice.
Hughes DP, Hayday A, Craft JE, Owen MJ, Crispe IN. T cells with gamma/delta T cell receptors (TCR) of intestinal type are preferentially expanded in TCR-alpha-deficient lpr mice. Journal Of Experimental Medicine 1995, 182: 233-241. PMID: 7540652, PMCID: PMC2192080, DOI: 10.1084/jem.182.1.233.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, SurfaceApoptosisBase SequenceCell DivisionCell MovementDNA Transposable ElementsFas ReceptorImmunophenotypingIntestinal MucosaLymph NodesLymphocyte CountLymphoproliferative DisordersMiceMice, KnockoutMice, Mutant StrainsMolecular Sequence DataReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaSpecific Pathogen-Free OrganismsT-Lymphocyte SubsetsConceptsLpr/lpr miceT cell receptorIntestinal intraepithelial lymphocytesLpr miceT cellsIntraepithelial lymphocytesAlpha/beta T cellsGamma/delta T cell receptorGamma/delta T cellsLymph node cell numberTCR gamma/deltaDelta T-cell receptorFas-deficient lpr micePeripheral lymphoid systemT-cell contributionPeripheral lymph nodesBeta T cellsDelta T cellsActivation-induced cell deathGene-ablated miceRole of FasT cell developmentLymph nodesIntestinal typeLymphoid system