2021
Type I Interferon–Activated STAT4 Regulation of Follicular Helper T Cell–Dependent Cytokine and Immunoglobulin Production in Lupus
Dong X, Antao OQ, Song W, Sanchez GM, Zembrzuski K, Koumpouras F, Lemenze A, Craft J, Weinstein JS. Type I Interferon–Activated STAT4 Regulation of Follicular Helper T Cell–Dependent Cytokine and Immunoglobulin Production in Lupus. Arthritis & Rheumatology 2021, 73: 478-489. PMID: 33512094, PMCID: PMC7914134, DOI: 10.1002/art.41532.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntibody FormationAutoantibodiesB-LymphocytesCase-Control StudiesCytokinesDisease Models, AnimalFemaleHumansImmunoglobulinsInterferon Type IInterferon-gammaInterleukinsLupus Erythematosus, SystemicMaleMice, Inbred MRL lprMiddle AgedRNA-SeqSTAT4 Transcription FactorT Follicular Helper CellsConceptsSystemic lupus erythematosusTfh-like cellsTfh cellsIL-21Human lupusDisease activityCytokine productionSTAT4 activationImmunoglobulin productionPathogenic B cell responsesCourse of lupusClinical disease activityT cell secretionLupus-prone miceHealthy control subjectsCourse of diseaseB cell responsesCytokine interleukin-21Potential therapeutic targetType I IFNB cell maturationSLE patientsPathogenic cytokinesLupus erythematosusInterleukin-21
2019
Impaired ATM activation in B cells is associated with bone resorption in rheumatoid arthritis
Mensah KA, Chen JW, Schickel JN, Isnardi I, Yamakawa N, Vega-Loza A, Anolik JH, Gatti RA, Gelfand EW, Montgomery RR, Horowitz MC, Craft JE, Meffre E. Impaired ATM activation in B cells is associated with bone resorption in rheumatoid arthritis. Science Translational Medicine 2019, 11 PMID: 31748230, PMCID: PMC7167286, DOI: 10.1126/scitranslmed.aaw4626.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisB cellsHealthy donor controlsGroup of patientsHumanized mouse modelImmature B cellsGene segment usageErosive diseaseRA pathophysiologyBone erosionBone lossBone resorptionHigh prevalenceRANKL productionBone densityMouse modelReceptor activatorBone marrowPatientsDonor controlsCD21Segment usageArthritisElevated frequencyAtaxia telangiectasia
2015
Circulating Follicular Helper–Like T Cells in Systemic Lupus Erythematosus: Association With Disease Activity
Choi J, Ho J, Pasoto SG, Bunin V, Kim ST, Carrasco S, Borba EF, Gonçalves CR, Costa PR, Kallas EG, Bonfa E, Craft J. Circulating Follicular Helper–Like T Cells in Systemic Lupus Erythematosus: Association With Disease Activity. Arthritis & Rheumatology 2015, 67: 988-999. PMID: 25581113, PMCID: PMC4450082, DOI: 10.1002/art.39020.Peer-Reviewed Original ResearchConceptsTfh-like cellsSLE Disease Activity IndexSystemic lupus erythematosusInducible T-cell costimulatorPD-1 expressionDisease activityT cellsBehçet's diseaseSLE patientsLupus erythematosusBlood samplesT cell-B cell collaborationCentral memory T cellsExpression of CXCR5Disease activity indexGerminal center activityMemory T cellsDeath 1 proteinFollicular helper TT-cell costimulatorActive diseaseAntibody positivityDisease durationFollicular helperIL-21
2011
The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice
Tang W, Lu Y, Tian QY, Zhang Y, Guo FJ, Liu GY, Syed NM, Lai Y, Lin EA, Kong L, Su J, Yin F, Ding AH, Zanin-Zhorov A, Dustin ML, Tao J, Craft J, Yin Z, Feng JQ, Abramson SB, Yu XP, Liu CJ. The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice. Science 2011, 332: 478-484. PMID: 21393509, PMCID: PMC3104397, DOI: 10.1126/science.1199214.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAnimalsAnti-Inflammatory Agents, Non-SteroidalArthritis, ExperimentalCartilage, ArticularFemaleGranulinsHumansIntercellular Signaling Peptides and ProteinsLigandsMaleMiceMice, Inbred StrainsMice, KnockoutMice, TransgenicMiddle AgedProgranulinsProtein Interaction Domains and MotifsReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IIRecombinant Fusion ProteinsRecombinant ProteinsSignal TransductionT-Lymphocytes, RegulatoryTumor Necrosis Factor-alphaYoung AdultConceptsInflammatory arthritisAdministration of progranulinAntagonist of TNFαCollagen-induced arthritisArthritis mouse modelPGRN-deficient miceNew potential therapeutic interventionsPotential therapeutic interventionsGrowth factor progranulinNecrosis factor receptorRheumatoid arthritisMouse modelArthritisTherapeutic interventionsProgranulinTNF receptorFactor receptorMiceReceptorsInflammationTissue repairTNFαIntracellular signalingAtsttrinTNFR
2008
Autoantibodies against cyclophilin in systemic lupus erythematosus and Lyme disease
KRATZ A, HARDING MW, CRAFT J, MACKWORTH-YOUNG C, HANDSCHUMACHER RE. Autoantibodies against cyclophilin in systemic lupus erythematosus and Lyme disease. Clinical & Experimental Immunology 2008, 90: 422-427. PMID: 1458678, PMCID: PMC1554566, DOI: 10.1111/j.1365-2249.1992.tb05862.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAmino Acid IsomerasesAntibodies, Anti-IdiotypicAntibodies, MonoclonalAntibody SpecificityAutoantibodiesCarrier ProteinsChildEnzyme-Linked Immunosorbent AssayFamily HealthFemaleHumansImmunoglobulin GImmunoglobulin IdiotypesImmunoglobulin MLupus Erythematosus, SystemicLyme DiseaseMaleMiddle AgedPeptidylprolyl IsomeraseProtein DenaturationConceptsSystemic lupus erythematosusLupus erythematosusFirst-degree relativesLyme disease patientsMonoclonal IgM antibodyLupus patientsIgM antibodiesDisease patientsLepromatous leprosyImmune systemPatientsWestern blotLyme diseaseAntibodiesErythematosusAutoantibodiesHypergammaglobulinaemiaCyclophilinCyclosporinLeprosyDiseaseSerum
2004
Defective Control of Latent Epstein-Barr Virus Infection in Systemic Lupus Erythematosus
Kang I, Quan T, Nolasco H, Park SH, Hong MS, Crouch J, Pamer EG, Howe JG, Craft J. Defective Control of Latent Epstein-Barr Virus Infection in Systemic Lupus Erythematosus. The Journal Of Immunology 2004, 172: 1287-1294. PMID: 14707107, DOI: 10.4049/jimmunol.172.2.1287.Peer-Reviewed Original ResearchMeSH KeywordsAdultB-Lymphocyte SubsetsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCytomegalovirusEpitopes, T-LymphocyteEpstein-Barr Virus InfectionsFemaleHerpesvirus 4, HumanHumansLeukocytes, MononuclearLupus Erythematosus, SystemicLymphocyte CountMaleMiddle AgedSeverity of Illness IndexViral LoadVirus LatencyConceptsSystemic lupus erythematosusEBV viral loadT cell responsesViral loadT cellsIFN-gammaCell responsesEBV infectionLupus erythematosusHealthy controlsEBV-specific T-cell responsesVirus-specific T cell responsesLatent Epstein-Barr virus (EBV) infectionEBV-specific immune responsesEpstein-Barr virus infectionAltered T-cell responsesDefective controlFrequency of CD69HLA-A2 tetramersTetramer-positive CD8Latent EBV infectionEBV-specificImmunosuppressive medicationsDisease activityLupus patients
1997
The transcriptional activator Sp1, a novel autoantigen
Spain T, Sun R, Gradzka M, Lin S, Craft J, Miller G. The transcriptional activator Sp1, a novel autoantigen. Arthritis & Rheumatism 1997, 40: 1085-1095. PMID: 9182919, DOI: 10.1002/art.1780400613.Peer-Reviewed Original ResearchConceptsTranscriptional activator Sp1Novel autoantigenComplex of DNAGC-rich sequencesActivator Sp1Undifferentiated connective tissue diseaseSp1 proteinTranscription activatorConnective tissue diseaseExtractable nuclear antigensEpstein-Barr virusSp1Nuclear extractsCellular DNAMalar rashAntinuclear antibodiesClinical characteristicsProteinDNARaynaud's phenomenonTissue diseaseAutoantigenic proteinsAutoimmune seraElectrophoretic mobilityAutoantigensA man with fever and petechiae
Greene W, Craft J. A man with fever and petechiae. The Lancet 1997, 349: 696. PMID: 9078202, DOI: 10.1016/s0140-6736(96)11204-6.Peer-Reviewed Original Research
1996
Anti-U5 Small Nuclear Ribonucleoprotein (snRNP) Antibodies: A Rare Anti-U snRNP Specificity
Okano Y, Targoff I, Oddis C, Fujii T, Kuwana M, Tsuzaka K, Hirakata M, Mimori T, Craft J, Medsger T. Anti-U5 Small Nuclear Ribonucleoprotein (snRNP) Antibodies: A Rare Anti-U snRNP Specificity. Clinical Immunology 1996, 81: 41-47. PMID: 8808640, DOI: 10.1006/clin.1996.0155.Peer-Reviewed Original ResearchAutoantibodies to glycyl–transfer RNA synthetase in myositis. Association with dermatomyositis and immunologic heterogeneity
Hirakata M, Suwa A, Takeda Y, Matsuoka Y, Irimajiri S, Targoff I, Hardin J, Craft J. Autoantibodies to glycyl–transfer RNA synthetase in myositis. Association with dermatomyositis and immunologic heterogeneity. Arthritis & Rheumatism 1996, 39: 146-151. PMID: 8546723, DOI: 10.1002/art.1780390119.Peer-Reviewed Original ResearchConceptsTRNA synthetase antibodiesImmunologic heterogeneitySynthetase antibodiesTransfer RNA synthetase antibodiesPolymyositis/dermatomyositisInterstitial lung diseaseIdentification of antibodiesRheumatic diseasesLung diseaseClinical significanceEpitope specificityPatientsAutoantibodiesImmunoblotting findingsSerumAntibodiesDiseaseDermatomyositisMyositisRNA synthetaseImmunoprecipitation assaysAssociationGlycyl-tRNA synthetaseSpecificityFindings
1987
A human IgM M-protein in a patient with unknown bleeding disorder binds to β-galactosyl and β-glucosyl residues
Kusunoki S, Craft J, Roach B, Hardin J, Yu R. A human IgM M-protein in a patient with unknown bleeding disorder binds to β-galactosyl and β-glucosyl residues. Archives Of Biochemistry And Biophysics 1987, 255: 226-232. PMID: 3592674, DOI: 10.1016/0003-9861(87)90389-4.Peer-Reviewed Original Research
1983
The early clinical manifestations of Lyme disease.
Steere AC, Bartenhagen NH, Craft JE, Hutchinson GJ, Newman JH, Rahn DW, Sigal LH, Spieler PN, Stenn KS, Malawista SE. The early clinical manifestations of Lyme disease. Annals Of Internal Medicine 1983, 99: 76-82. PMID: 6859726, DOI: 10.7326/0003-4819-99-1-76.Peer-Reviewed Original ResearchConceptsLyme diseaseSkin lesionsElevated serum IgM levelsMigratory musculoskeletal painTick-transmitted spirochetesUnique skin lesionAspartate transaminase levelsEarly clinical manifestationsEarly Lyme diseaseSerum IgM levelsErythema chronicum migransMeningeal irritationLaboratory abnormalitiesNonproductive coughTransaminase levelsUrticarial rashMusculoskeletal painRegional lymphadenopathySkin manifestationsSore throatDermatologic manifestationsSerologic testingClinical manifestationsIgM levelsPeriorbital edemaClinical Findings in Southeast Asian Refugees: Child Development and Public Health Concerns
Barry M, Craft J, Coleman D, Coulter H, Horwitz R. Clinical Findings in Southeast Asian Refugees: Child Development and Public Health Concerns. JAMA 1983, 249: 3200-3203. PMID: 6854849, DOI: 10.1001/jama.1983.03330470040028.Peer-Reviewed Original ResearchConceptsFifth percentilePositive tuberculin test resultsNutrition-related health problemsClinical nutritional assessmentHepatitis B antigenemiaSoutheast Asian refugeesComprehensive medical careTuberculin test resultsPublic health concernClinical findingsNutritional assessmentAsian refugeesClinical assessmentIntestinal parasitismHigh prevalenceHealth problemsMedical careStandard growth curvesHealth authoritiesHealth concernRefugee childrenChild developmentChildrenPercentileAntigenemiaHematologic Abnormalities in Southeast Asian Refugees
Craft J, Coleman D, Coulter H, Horwitz R, Barry M. Hematologic Abnormalities in Southeast Asian Refugees. JAMA 1983, 249: 3204-3206. PMID: 6854850, DOI: 10.1001/jama.1983.03330470044029.Peer-Reviewed Original Research
1980
Psoriatic Arthritis and Aortic Regurgitation
Muna W, Roller D, Craft J, Shaw R, Ross A. Psoriatic Arthritis and Aortic Regurgitation. JAMA 1980, 244: 363-365. PMID: 7392130, DOI: 10.1001/jama.1980.03310040045027.Peer-Reviewed Original ResearchMeSH KeywordsAortic ValveAortic Valve InsufficiencyArthritisHLA AntigensHumansMaleMiddle AgedPsoriasisConceptsAortic regurgitationPsoriatic arthritisCardiac lesionsConduction tissueMajor cardiac involvementSevere psoriatic arthritisClassic rheumatoid arthritisConnective tissue diseaseNew murmurChest painCardiac involvementPericardial involvementHLA-B27Myocardial dysfunctionPathological findingsRheumatoid arthritisSerological featuresAortic valveSurgical replacementHistological examinationNative valveVascular componentArthritisTen-year historyCardiac component
1975
Ultrastructural description of a "cylinder organelle" in the outer plexiform layer of human retinas.
Craft J, Albert DM, Reid TW. Ultrastructural description of a "cylinder organelle" in the outer plexiform layer of human retinas. Invest Ophthal 1975, 14: 923-7. PMID: 1193806.Peer-Reviewed Original Research