2011
The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice
Tang W, Lu Y, Tian QY, Zhang Y, Guo FJ, Liu GY, Syed NM, Lai Y, Lin EA, Kong L, Su J, Yin F, Ding AH, Zanin-Zhorov A, Dustin ML, Tao J, Craft J, Yin Z, Feng JQ, Abramson SB, Yu XP, Liu CJ. The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice. Science 2011, 332: 478-484. PMID: 21393509, PMCID: PMC3104397, DOI: 10.1126/science.1199214.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAnimalsAnti-Inflammatory Agents, Non-SteroidalArthritis, ExperimentalCartilage, ArticularFemaleGranulinsHumansIntercellular Signaling Peptides and ProteinsLigandsMaleMiceMice, Inbred StrainsMice, KnockoutMice, TransgenicMiddle AgedProgranulinsProtein Interaction Domains and MotifsReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IIRecombinant Fusion ProteinsRecombinant ProteinsSignal TransductionT-Lymphocytes, RegulatoryTumor Necrosis Factor-alphaYoung AdultConceptsInflammatory arthritisAdministration of progranulinAntagonist of TNFαCollagen-induced arthritisArthritis mouse modelPGRN-deficient miceNew potential therapeutic interventionsPotential therapeutic interventionsGrowth factor progranulinNecrosis factor receptorRheumatoid arthritisMouse modelArthritisTherapeutic interventionsProgranulinTNF receptorFactor receptorMiceReceptorsInflammationTissue repairTNFαIntracellular signalingAtsttrinTNFR
2003
Oxazolone and diclofenac-induced popliteal lymph node assay reactions are attenuated in mice orally pretreated with the respective compound: potential role for the induction of regulatory mechanisms following enteric administration☆
Gutting BW, Bouzahzah F, Kong PL, Updyke LW, Amacher DE, Craft J. Oxazolone and diclofenac-induced popliteal lymph node assay reactions are attenuated in mice orally pretreated with the respective compound: potential role for the induction of regulatory mechanisms following enteric administration☆. Toxicology And Applied Pharmacology 2003, 189: 120-133. PMID: 12781630, DOI: 10.1016/s0041-008x(03)00091-7.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAdministration, OralAdoptive TransferAnimalsAnti-Inflammatory Agents, Non-SteroidalCD8-Positive T-LymphocytesDiclofenacDrug HypersensitivityLocal Lymph Node AssayLymph NodesMiceMice, Inbred BALB COxazoloneSpleenConceptsPopliteal lymph node assayPLN reactionDose-dependent increaseNaive micePLN T cellsT cellsOral toleranceFootpad injectionNaive BALB/c miceBALB/c miceContact sensitizer oxazoloneAdoptive transfer studiesDrug hypersensitivity reactionsLymph node assayEnteric administrationOral pretreatmentHypersensitivity reactionsPopliteal lymphC miceUnfractionated splenocytesNSAID diclofenacB cellsRespective drugsSplenocytesPreclinical assays