2012
Caspase‐activated DNase is required for maintenance of tolerance to lupus nuclear autoantigens
Jog NR, Frisoni L, Shi Q, Monestier M, Hernandez S, Craft J, Prak ET, Caricchio R. Caspase‐activated DNase is required for maintenance of tolerance to lupus nuclear autoantigens. Arthritis & Rheumatism 2012, 64: 1247-1256. PMID: 22127758, PMCID: PMC3292632, DOI: 10.1002/art.33448.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearApoptosisAutoantigensCell NucleusDeoxyribonucleasesDisease Models, AnimalImmune ToleranceLupus Erythematosus, SystemicMiceConceptsSystemic lupus erythematosusAutoimmune responseMouse modelApoptotic cellsNuclear autoantigensDNA antibody titersLupus-prone miceAbsence of CADMaintenance of toleranceAutoreactive B cellsAnti-DNA antibodiesApoptotic modificationsLupus developmentGeneration of autoantigensAntinuclear antibodiesLupus erythematosusAntibody titersAutoimmune diseasesActive caspase-3Apoptotic bodiesB cellsMiceAutoantigensCAD deficiencyCaspase-3
2002
The transmembrane form of TNF-α drives autoantibody production in the absence of CD154: studies using MRL/Mp-Faslpr mice
FUJII T, OKADA M, MIMORI T, CRAFT J. The transmembrane form of TNF-α drives autoantibody production in the absence of CD154: studies using MRL/Mp-Faslpr mice. Clinical & Experimental Immunology 2002, 130: 224-232. PMID: 12390309, PMCID: PMC1906522, DOI: 10.1046/j.1365-2249.2002.01982.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearB-LymphocytesCD40 LigandCell LineCells, CulturedCoculture TechniquesLupus Erythematosus, SystemicLymphocyte ActivationLymphocyte CooperationMembrane ProteinsMiceMice, Inbred MRL lprMice, KnockoutReceptors, Antigen, T-Cell, alpha-betaReceptors, Tumor Necrosis FactorRibonucleoproteins, Small NuclearTh1 CellsTumor Necrosis Factor-alphaConceptsB cell proliferationTh1 linesTNF-alphaB cellsAntibody productionCell proliferationContact-dependent helpMRL/MpB cell helpMHC class IITh1 cell linesB cell activationCD40-CD154Autoantibody productionTh1 cellsCell helpMRL miceMTNF-alphaProliferative responseHigh titresCell activationTNF-R2Class IITransmembrane formMonoclonal antibodiesRegulation of T cell-dependent autoantibody production by a γδ T cell line derived from lupus-prone mice
Fujii T, Okada M, Craft J. Regulation of T cell-dependent autoantibody production by a γδ T cell line derived from lupus-prone mice. Cellular Immunology 2002, 217: 23-35. PMID: 12425998, DOI: 10.1016/s0008-8749(02)00509-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearApoptosisB-LymphocytesCell LineCoculture TechniquesCytotoxicity Tests, ImmunologicDNAInterleukin-10Lupus Erythematosus, SystemicLymphocyte ActivationLymphocyte CooperationMiceMice, Inbred C57BLMice, Inbred MRL lprMice, KnockoutReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocytes, Helper-InducerTumor Necrosis Factor-alphaConceptsGammadelta T cell linesT cell linesAnti-dsDNA productionMRL/B cellsAutoantibody productionCell linesLupus-prone miceMRL/MpGammadelta T cellsT helper cell linesB cell collaborationActivated B cellsContact-dependent mannerAlphabeta TSevere lupusGammadelta TAutoantibody synthesisMurine lupusLupus-proneT cellsCell collaborationHelper cell lineMiceLupus
1997
The transcriptional activator Sp1, a novel autoantigen
Spain T, Sun R, Gradzka M, Lin S, Craft J, Miller G. The transcriptional activator Sp1, a novel autoantigen. Arthritis & Rheumatism 1997, 40: 1085-1095. PMID: 9182919, DOI: 10.1002/art.1780400613.Peer-Reviewed Original ResearchConceptsTranscriptional activator Sp1Novel autoantigenComplex of DNAGC-rich sequencesActivator Sp1Undifferentiated connective tissue diseaseSp1 proteinTranscription activatorConnective tissue diseaseExtractable nuclear antigensEpstein-Barr virusSp1Nuclear extractsCellular DNAMalar rashAntinuclear antibodiesClinical characteristicsProteinDNARaynaud's phenomenonTissue diseaseAutoantigenic proteinsAutoimmune seraElectrophoretic mobilityAutoantigens
1996
Systemic autoimmunity in LGJ mice
Peng S, Madaio M, Craft J. Systemic autoimmunity in LGJ mice. Immunology Letters 1996, 53: 153-155. PMID: 9024995, DOI: 10.1016/s0165-2478(96)02616-8.Peer-Reviewed Original ResearchConceptsLG/J miceJ miceAnalysis of autoimmunityEnd-organ diseaseNon-diseased animalsAntinuclear antibodiesInterstitial nephritisLupus erythematosusRenal diseaseRheumatoid factorCutaneous diseaseSystemic autoimmunityMurine modelControl animalsJ strainJ backgroundAutoimmunityDiseaseMiceAutoantibodiesUseful modelAnimalsErythematosusPerivasculitisGlomerulonephritisAnti-U5 Small Nuclear Ribonucleoprotein (snRNP) Antibodies: A Rare Anti-U snRNP Specificity
Okano Y, Targoff I, Oddis C, Fujii T, Kuwana M, Tsuzaka K, Hirakata M, Mimori T, Craft J, Medsger T. Anti-U5 Small Nuclear Ribonucleoprotein (snRNP) Antibodies: A Rare Anti-U snRNP Specificity. Clinical Immunology 1996, 81: 41-47. PMID: 8808640, DOI: 10.1006/clin.1996.0155.Peer-Reviewed Original ResearchMurine lupus in the absence of alpha beta T cells.
Peng SL, Madaio MP, Hughes DP, Crispe IN, Owen MJ, Wen L, Hayday AC, Craft J. Murine lupus in the absence of alpha beta T cells. The Journal Of Immunology 1996, 156: 4041-9. PMID: 8621947, DOI: 10.4049/jimmunol.156.10.4041.Peer-Reviewed Original ResearchConceptsAlpha beta T cellsT cell-dependent mechanismBeta T cellsCell-dependent mechanismT cellsMurine lupusHuman systemic lupus erythematosusLupus-prone MRL miceSystemic lupus erythematosusSystemic autoimmune diseaseLupus erythematosusAutoimmune diseasesImmune depositsMRL miceAlpha betaLupusDiseaseMiceCellsErythematosusHypergammaglobulinemiaAutoantibodiesCD4AutoimmunityKidney
1990
The analysis of antinuclear and antinucleolar autoantibodies of scleroderma by radioimmunoprecipitation assays
Kipnis R, Craft J, Hardin J. The analysis of antinuclear and antinucleolar autoantibodies of scleroderma by radioimmunoprecipitation assays. Arthritis & Rheumatism 1990, 33: 1431-1437. PMID: 2403405, DOI: 10.1002/art.1780330917.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, AntinuclearAntibody SpecificityFemaleHumansMalePrecipitin TestsRadioimmunoassayScleroderma, SystemicConceptsCommon antibody specificitiesPrimary Raynaud's phenomenonScleroderma overlap syndromeOverlap syndromeDiffuse sclerodermaRaynaud's phenomenonRNP antibodiesCREST syndromeAntinucleolar autoantibodiesAmerican patientsRadioimmunoprecipitation assaysAutoantibodiesIndirect immunofluorescenceSclerodermaAntibody specificityNucleolar antigensPatientsSyndromeAntibodiesImmunoprecipitation assaysAssays
1989
Biochemical and immunological heterogeneity of the Ro ribonucleoprotein particles. Analysis with sera specific for the RohY5 particle.
Boire G, Craft J. Biochemical and immunological heterogeneity of the Ro ribonucleoprotein particles. Analysis with sera specific for the RohY5 particle. Journal Of Clinical Investigation 1989, 84: 270-279. PMID: 2472427, PMCID: PMC303979, DOI: 10.1172/jci114150.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, AntinuclearAutoradiographyElectrophoresis, Gel, Two-DimensionalEpitopesHumansLupus Erythematosus, SystemicPrecipitin TestsRibonucleoproteinsRNAConceptsSystemic lupus erythematosusRelated diseasesRo particleAnti-Ro autoantibodiesAnti-Ro seraCell fractionRo antibodiesSystemic lupusLupus erythematosusPatient seraImmunological heterogeneityAutoantibodiesSpecific serumRo responseNonhuman cell linesSerumAntigenic determinantsAntibodiesCell linesInhibition assaysDiseaseEpitopesCompetitive inhibitionSuch extractsErythematosus
1987
Linked sets of antinuclear antibodies: what do they mean?
Craft JE, Hardin JA. Linked sets of antinuclear antibodies: what do they mean? Journal Of Rheumatology Supplement 1987, 14 Suppl 13: 106-9. PMID: 2441041.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, AntinuclearAntibody SpecificityAutoantigensEpitopesHumansLupus Erythematosus, SystemicRibonucleoproteinsPatterns of Autoimmunity to Nucleoproteins in Patients with Systemic Lupus Erythematosus
Hardin J, Craft J. Patterns of Autoimmunity to Nucleoproteins in Patients with Systemic Lupus Erythematosus. Rheumatic Disease Clinics Of North America 1987, 13: 37-46. PMID: 3306823, DOI: 10.1016/s0889-857x(21)00820-6.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, AntinuclearChildChromatinHumansLupus Erythematosus, SystemicNucleoproteinsRibonucleoproteinsConceptsAnti-Ro antibodiesAnti-DNA antibodiesAnti-Sm antibodiesAutoimmune responseAnti-U1 RNP antibodiesB lymphocyte hyperactivityPatterns of autoimmunitySystemic lupus erythematosusRo particleAnti-U1 RNPAnti-La antibodiesB lymphocyte clonesLupus erythematosusRNP antibodiesImmune regulationImmune responseH2B antibodiesAntibodiesAnti-histone H1Different antibodiesNucleoproteinResponseGeneral defectErythematosusAutoantibodies