2014
B Cells in T Follicular Helper Cell Development and Function: Separable Roles in Delivery of ICOS Ligand and Antigen
Weinstein JS, Bertino SA, Hernandez SG, Poholek AC, Teplitzky TB, Nowyhed HN, Craft J. B Cells in T Follicular Helper Cell Development and Function: Separable Roles in Delivery of ICOS Ligand and Antigen. The Journal Of Immunology 2014, 192: 3166-3179. PMID: 24610013, PMCID: PMC3991608, DOI: 10.4049/jimmunol.1302617.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigensAntigens, CD19B-LymphocytesCell ProliferationDNA-Binding ProteinsFlow CytometryInducible T-Cell Co-Stimulator LigandMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMicroscopy, ConfocalNitrophenolsOvalbuminPhenylacetatesProto-Oncogene Proteins c-bcl-6Reverse Transcriptase Polymerase Chain ReactionT-LymphocytesT-Lymphocytes, Helper-InducerConceptsCognate B cellsTfh cell developmentB cellsICOS ligandFollicular Th cell developmentCell developmentNoncognate B cellsFollicular helper cell developmentTfh cell differentiationAg-specific B cellsICOS-L expressionB cell expressionTh cell developmentGerminal center differentiationICOS blockadeTfh cellsAg deliverySystemic autoimmunityCell expressionCell maturationICOSCellsDeliveryCell differentiationCells display
2013
CD301b+ Dermal Dendritic Cells Drive T Helper 2 Cell-Mediated Immunity
Kumamoto Y, Linehan M, Weinstein JS, Laidlaw BJ, Craft JE, Iwasaki A. CD301b+ Dermal Dendritic Cells Drive T Helper 2 Cell-Mediated Immunity. Immunity 2013, 39: 733-743. PMID: 24076051, PMCID: PMC3819035, DOI: 10.1016/j.immuni.2013.08.029.Peer-Reviewed Original ResearchConceptsDermal dendritic cellsDendritic cellsDermal DCsTh2 cellsT cellsT helper 2 cellsT helper responsesInterleukin-4 productionExpression of CD69Th2 cell developmentDC depletionLymph nodesTh2 immunityHelper responsesSubcutaneous immunizationNippostrongylus brasiliensisKey mediatorTransient depletionCell developmentImmunityOvalbuminDepletion approachCellsParticular subsetCD301b
2005
Role for macrophage migration inhibitory factor in asthma
Mizue Y, Ghani S, Leng L, McDonald C, Kong P, Baugh J, Lane SJ, Craft J, Nishihira J, Donnelly SC, Zhu Z, Bucala R. Role for macrophage migration inhibitory factor in asthma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 14410-14415. PMID: 16186482, PMCID: PMC1242335, DOI: 10.1073/pnas.0507189102.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAsthmaBase SequenceBronchoalveolar LavageCell ProliferationCells, CulturedCytokinesEnzyme-Linked Immunosorbent AssayFlow CytometryGene ComponentsGenotypeHumansInterleukin-5Intramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMiceMice, Inbred BALB CMice, KnockoutOvalbuminReverse Transcriptase Polymerase Chain ReactionT-Lymphocytes, Helper-InducerConceptsMacrophage migration inhibitory factorMigration inhibitory factorInhibitory factorIL-5 concentrationsLower airway hyperresponsivenessBronchoalveolar lavage fluidAntigen-specific responsesT-cell studiesWild-type miceLess pulmonary inflammationAirway hyperresponsivenessImmunologic regulatorsMIF deficiencyMIF KOMIF's roleMild asthmaWild-type controlsSevere asthmaAsthma patientsCytokine levelsMIF genotypePulmonary inflammationSpecific IgEWhite patientsAutoimmune disorders