2017
Increased Oxidative Stress and Hypoxia Inducible Factor-1 Expression during Arteriovenous Fistula Maturation
Sadaghianloo N, Yamamoto K, Bai H, Tsuneki M, Protack CD, Hall MR, Declemy S, Hassen-Khodja R, Madri J, Dardik A. Increased Oxidative Stress and Hypoxia Inducible Factor-1 Expression during Arteriovenous Fistula Maturation. Annals Of Vascular Surgery 2017, 41: 225-234. PMID: 28163173, PMCID: PMC5411319, DOI: 10.1016/j.avsg.2016.09.014.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaArteriovenous Shunt, SurgicalGene Expression RegulationHeme Oxygenase-1Hydrogen PeroxideHyperplasiaHypoxia-Inducible Factor 1, alpha SubunitMaleMembrane ProteinsMice, Inbred C57BLNADPH Oxidase 2NeointimaOxidative StressReactive Oxygen SpeciesSignal TransductionTime FactorsTyrosineVascular Endothelial Growth Factor AVascular PatencyVena Cava, InferiorConceptsHeme oxygenase-1Arteriovenous fistulaAVF maturationNOX-2HIF-1αOxidative stressHypoxia-inducible factor 1 (HIF-1) expressionSham-operated micePoor clinical resultsHIF-1α immunoreactivityInferior vena cavaArteriovenous fistula maturationVascular endothelial growth factorHypoxia-inducible factor-1 (HIF-1) pathwayFactor-1 expressionEndothelial growth factorHIF-1 pathwayHuman AVF maturationQuantitative polymerase chain reactionOxidative stress increasesAortocaval fistulaFistula maturationVena cavaClinical resultsPolymerase chain reaction
2015
Disturbed shear stress reduces Klf2 expression in arterial‐venous fistulae in vivo
Yamamoto K, Protack CD, Kuwahara G, Tsuneki M, Hashimoto T, Hall MR, Assi R, Brownson KE, Foster TR, Bai H, Wang M, Madri JA, Dardik A. Disturbed shear stress reduces Klf2 expression in arterial‐venous fistulae in vivo. Physiological Reports 2015, 3: e12348. PMID: 25780089, PMCID: PMC4393175, DOI: 10.14814/phy2.12348.Peer-Reviewed Original ResearchArteriovenous fistulaKLF2 expressionDisturbed shear stressFistula diameterMouse aortocaval fistula modelArterial-venous fistulaProtein expressionAortocaval fistula modelInferior vena cavaPotential therapeutic targetAVF maturationAVF patencyDuplex ultrasoundArterial inflowVena cavaVenous outflowArterial limbVenous limbFistula modelMouse modelArterial samplesFistulaTherapeutic targetWestern blotGauge needle
2013
The mouse aortocaval fistula recapitulates human arteriovenous fistula maturation
Yamamoto K, Protack CD, Tsuneki M, Hall MR, Wong DJ, Lu DY, Assi R, Williams WT, Sadaghianloo N, Bai H, Miyata T, Madri JA, Dardik A. The mouse aortocaval fistula recapitulates human arteriovenous fistula maturation. AJP Heart And Circulatory Physiology 2013, 305: h1718-h1725. PMID: 24097429, PMCID: PMC3882542, DOI: 10.1152/ajpheart.00590.2013.Peer-Reviewed Original ResearchConceptsArteriovenous fistulaMaturation failureHigh-resolution Doppler ultrasoundArteriovenous fistula maturationFirst animal modelMature arteriovenous fistulaSmooth muscle cellsHuman AVF maturationAVF maturationAortocaval fistulaAVF failureFistula maturationImmediate thrombosisVenous adaptationExcellent patencyDoppler ultrasoundAnimal modelsDay 21Human patientsNeedle punctureDay 42Muscle cellsFistulaArterial environmentFailure