2013
CD44 Deficiency Contributes to Enhanced Experimental Autoimmune Encephalomyelitis A Role in Immune Cells and Vascular Cells of the Blood–Brain Barrier
Flynn KM, Michaud M, Madri JA. CD44 Deficiency Contributes to Enhanced Experimental Autoimmune Encephalomyelitis A Role in Immune Cells and Vascular Cells of the Blood–Brain Barrier. American Journal Of Pathology 2013, 182: 1322-1336. PMID: 23416161, PMCID: PMC3620422, DOI: 10.1016/j.ajpath.2013.01.003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood-Brain BarrierBone Marrow CellsCell AdhesionCell MovementCell PolarityChimeraEncephalomyelitis, Autoimmune, ExperimentalEndothelial CellsGene DeletionHyaluronan ReceptorsInflammationInflammation MediatorsMiceMice, Inbred C57BLMice, KnockoutPermeabilityProtein Serine-Threonine KinasesReceptor, Transforming Growth Factor-beta Type IReceptors, Transforming Growth Factor betaStromal CellsT-Lymphocytes, RegulatoryConceptsExperimental autoimmune encephalomyelitisBlood-brain barrierCD44-deficient miceCytokine productionT cellsCD44 deficiencyDisease severityBone marrow chimeric animalsMyelin oligodendrocyte glycoprotein peptideBlood-brain barrier integrityT helper 17 (Th17) cellsT cell-endothelial cell interactionsImmune cell numbersRegulatory T cellsCD4 T cellsHelper 17 cellsCD44 knockout miceProinflammatory cytokine productionWild-type miceCentral nervous systemGreater disease severityT cell differentiationAdhesion molecule CD44Type I expressionMultiple protective roles
1993
Functional CD4 T cell subset interplay in an intact immune system.
Murray J, Madri J, Pasqualini T, Bottomly K. Functional CD4 T cell subset interplay in an intact immune system. The Journal Of Immunology 1993, 150: 4270-6. PMID: 8097751, DOI: 10.4049/jimmunol.150.10.4270.Peer-Reviewed Original ResearchConceptsCD4 T cellsTh-2 cellsT cellsIL-5Antibody formationIFN-gammaTh-2-like cellsF1 hybrid T cellsIntact immune systemTh-1 cellsGood proliferative responsesCollagen IVCell primingProliferative responseImmune systemTh-1Hybrid miceMiceGamma treatmentAdditional studiesHuman collagen IVImmunizationSelective activationVivoCellsSurface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma.
Baron JL, Madri JA, Ruddle NH, Hashim G, Janeway CA. Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma. Journal Of Experimental Medicine 1993, 177: 57-68. PMID: 7678116, PMCID: PMC2190872, DOI: 10.1084/jem.177.1.57.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalBrainCD4-Positive T-LymphocytesCell Adhesion MoleculesCell MovementClone CellsEncephalomyelitis, Autoimmune, ExperimentalIntercellular Adhesion Molecule-1MiceMice, Inbred BALB CMyelin Basic ProteinReceptors, Very Late AntigenVascular Cell Adhesion Molecule-1ConceptsAlpha 4 integrinsExperimental autoimmune encephalomyelitisAdhesion molecule-1T cellsBrain parenchymaT cell linesEncephalitogenic clonesAlpha 4Surface expressionMolecule-1Recombinant vascular cell adhesion molecule-1T helper type 1 clonesCD4 T cell linesCloned T cell linesTh1 cytokine interleukin-2Vascular cell adhesion molecule-1Intercellular adhesion molecule-1Cell adhesion molecule-1Tumor necrosis factor betaTh1 T cellsEffector T cellsCD4 T cellsMajor pathogenic factorT cell entryNecrosis factor beta
1992
Major histocompatibility complex (MHC) control of CD4 T cell subset activation. II. A single peptide induces either humoral or cell‐mediated responses in mice of distinct MHC genotype
Murray J, Pfeiffer C, Madri J, Bottomly K. Major histocompatibility complex (MHC) control of CD4 T cell subset activation. II. A single peptide induces either humoral or cell‐mediated responses in mice of distinct MHC genotype. European Journal Of Immunology 1992, 22: 559-565. PMID: 1347015, DOI: 10.1002/eji.1830220239.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibody FormationAntigen-Presenting CellsCD4-Positive T-LymphocytesCollagenGenes, MHC Class IIHaptensHumansImmunity, CellularImmunologic MemoryLymph NodesLymphocyte ActivationLymphocyte CooperationMajor Histocompatibility ComplexMiceMolecular Sequence DataPeptidesT-Lymphocytes, Helper-Inducer