1994
Effect of tyrosine kinase inhibition on basal and epidermal growth factor‐stimulated human Caco‐2 enterocyte sheet migration and proliferation
Basson M, Turowski G, Zarif A, Modlin I, Beidler D, Jena B, Madri J. Effect of tyrosine kinase inhibition on basal and epidermal growth factor‐stimulated human Caco‐2 enterocyte sheet migration and proliferation. Journal Of Cellular Physiology 1994, 160: 491-501. PMID: 8077287, DOI: 10.1002/jcp.1041600312.Peer-Reviewed Original ResearchConceptsEpidermal growth factorTyrosine kinaseTyrosine kinase regulationEGF-stimulated migrationProtein-linked DNA breaksSubstrate-binding siteTyrosine kinase inhibitor genisteinCell-matrix interactionsDNA topoisomerase activityKinase inhibitor genisteinKinase regulationATP bindingMonolayer expansionEGF stimulationSheet migrationSubunit organizationDNA breaksTopoisomerase activityEGF receptorInhibitor genisteinCell migrationCell proliferationKinase inhibitionTyrosine kinase inhibitionKinase
1992
Human enterocyte (Caco-2) migration is modulated in vitro by extracellular matrix composition and epidermal growth factor.
Basson M, Modlin I, Madri J. Human enterocyte (Caco-2) migration is modulated in vitro by extracellular matrix composition and epidermal growth factor. Journal Of Clinical Investigation 1992, 90: 15-23. PMID: 1634605, PMCID: PMC443057, DOI: 10.1172/jci115828.Peer-Reviewed Original ResearchConceptsEpidermal growth factorCaco-2 cellsGrowth factorEGF treatmentEnterocyte migrationHuman colonic cell lineColonic cell lineAlpha 2 subunitIntegrin surface expressionEGF-treated cellsAlpha integrin subunitsCollagen I.Functional antibodiesCell surface receptorsCollagen type IIntegrin expressionAlpha 2Basal migrationCell proliferationSurface expressionCollagen IExtracellular matrix compositionCell linesIntegrin subunitsSurface receptors