2003
Lack of Platelet Endothelial Cell Adhesion Molecule-1 Attenuates Foreign Body Inflammation because of Decreased Angiogenesis
Solowiej A, Biswas P, Graesser D, Madri JA. Lack of Platelet Endothelial Cell Adhesion Molecule-1 Attenuates Foreign Body Inflammation because of Decreased Angiogenesis. American Journal Of Pathology 2003, 162: 953-962. PMID: 12598328, PMCID: PMC1868115, DOI: 10.1016/s0002-9440(10)63890-4.Peer-Reviewed Original ResearchConceptsCell adhesion molecule-1Adhesion molecule-1Endothelial cell adhesion molecule-1Foreign body inflammationBody inflammationMolecule-1Knockout animalsAcute inflammatory modelForeign body implantsAntibody-blocking studiesPECAM-1 knockout micePlatelet endothelial cell adhesion molecule-1PECAM-1 resultsDiminished deliveryNeutrophil accumulationNeutrophil infiltrationLeukocyte accumulationInflammatory modelChronic processDecreased angiogenesisCD31 expressionKnockout miceMice exhibitEndothelial cellsLeukocyte transmigration
2000
PECAM-1 (CD31) Expression Modulates Bleeding Time in Vivo
Mahooti S, Graesser D, Patil S, Newman P, Duncan G, Mak T, Madri J. PECAM-1 (CD31) Expression Modulates Bleeding Time in Vivo. American Journal Of Pathology 2000, 157: 75-81. PMID: 10880378, PMCID: PMC1850208, DOI: 10.1016/s0002-9440(10)64519-1.Peer-Reviewed Original ResearchConceptsPECAM-1-deficient micePECAM-1Endothelial cellsNormal bleeding timeWild-type miceHematopoietic precursorsPolymorphonuclear leukocyte (PMN) transmigrationPECAM-1 expressionBleeding timePolymorphonuclear leukocytesAdjacent endothelial cellsMiceEndothelial cell migrationLeukocyte transmigrationBlood elementsExpression modulatesThrombosisPECAM-1 functions