2017
NOD Mice Having a Lyn Tyrosine Kinase Mutation Exhibit Abnormal Neutrophil Chemotaxis
Wu Y, Hannigan M, Zhan L, Madri JA, Huang C. NOD Mice Having a Lyn Tyrosine Kinase Mutation Exhibit Abnormal Neutrophil Chemotaxis. Journal Of Cellular Physiology 2017, 232: 1689-1695. PMID: 27591397, DOI: 10.1002/jcp.25583.Peer-Reviewed Original Research
2010
Myometrial Wound Healing Post-Cesarean Delivery in the MRL/MpJ Mouse Model of Uterine Scarring
Buhimschi CS, Zhao G, Sora N, Madri JA, Buhimschi IA. Myometrial Wound Healing Post-Cesarean Delivery in the MRL/MpJ Mouse Model of Uterine Scarring. American Journal Of Pathology 2010, 177: 197-207. PMID: 20489145, PMCID: PMC2893663, DOI: 10.2353/ajpath.2010.091209.Peer-Reviewed Original ResearchConceptsCesarean deliveryStrains of miceMRL strainSignificant differencesPost-cesarean deliveryTissue 3 daysUterine scarringMRL/Uterine scarUterine healingWound healing characteristicsMRL miceHistological indicesMouse modelDay 3Day 15Day 60Wall repairMiceMitotic activityWound repairBiomechanical parametersHealing characteristicsMyometriumBiomechanical properties
2009
Bone Marrow Monocyte PECAM-1 Deficiency Elicits Increased Osteoclastogenesis Resulting in Trabecular Bone Loss
Wu Y, Tworkoski K, Michaud M, Madri JA. Bone Marrow Monocyte PECAM-1 Deficiency Elicits Increased Osteoclastogenesis Resulting in Trabecular Bone Loss. The Journal Of Immunology 2009, 182: 2672-2679. PMID: 19234161, DOI: 10.4049/jimmunol.0802398.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsBone Marrow CellsBone ResorptionCell DifferentiationCells, CulturedDown-RegulationFemaleIntracellular Signaling Peptides and ProteinsMiceMice, KnockoutMonocytesOsteoclastsOsteogenesisPhosphorylationPlatelet Endothelial Cell Adhesion Molecule-1Protein Tyrosine Phosphatase, Non-Receptor Type 6Protein-Tyrosine KinasesSyk KinaseZAP-70 Protein-Tyrosine KinaseConceptsOsteoclast-like cellsKO miceBone marrowPECAM-1-null miceTrabecular bone lossPECAM-1Trabecular bone volumeSize of osteoclastsNF-kappaB ligandOsteoclast precursor culturesSHP-1 interactionsNumber of trabeculaeWT miceBM monocytesBone lossBone resorptionReceptor activatorBone volumeSHP-1Precursor culturesNull miceMiceLong bonesSyk kinaseFurther studies
2006
γδ T Cells Facilitate Adaptive Immunity against West Nile Virus Infection in Mice
Wang T, Gao Y, Scully E, Davis CT, Anderson JF, Welte T, Ledizet M, Koski R, Madri JA, Barrett A, Yin Z, Craft J, Fikrig E. γδ T Cells Facilitate Adaptive Immunity against West Nile Virus Infection in Mice. The Journal Of Immunology 2006, 177: 1825-1832. PMID: 16849493, DOI: 10.4049/jimmunol.177.3.1825.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsCD8-Positive T-LymphocytesGenetic Predisposition to DiseaseImmunity, CellularImmunity, InnateImmunization, SecondaryImmunoglobulin GImmunoglobulin MImmunologic MemoryLymphocyte DepletionMiceMice, Inbred C57BLMice, KnockoutReceptors, Antigen, T-Cell, gamma-deltaRecurrenceT-Lymphocyte SubsetsWest Nile FeverWest Nile virusConceptsGammadelta T cellsWild-type miceT cellsWN virus infectionPrimary infectionVirus infectionWN virusNaive miceSecondary challengeImmune responseAdaptive immunityCD8 memory T cellsWest Nile virus infectionMemory T cellsProtective immune responseAdaptive immune responsesAdoptive transferWest Nile virusAb responsesLethal infectionViral challengeFatal meningoencephalitisSecondary infectionInfectionMice
2002
Disrupted synaptic development in the hypoxic newborn brain
Curristin SM, Cao A, Stewart WB, Zhang H, Madri JA, Morrow JS, Ment LR. Disrupted synaptic development in the hypoxic newborn brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 15729-15734. PMID: 12438650, PMCID: PMC137784, DOI: 10.1073/pnas.232568799.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornApoptosisAtmosphere Exposure ChambersBrain Damage, ChronicCell DifferentiationCytoskeletonDisease Models, AnimalDNA, ComplementaryEndothelial Growth FactorsGene Expression ProfilingHypoxiaHypoxia, BrainHypoxia-Inducible Factor 1, alpha SubunitIntercellular Signaling Peptides and ProteinsLymphokinesMembrane ProteinsMiceMice, Inbred C57BLMicrotubulesNerve Tissue ProteinsOligodendrogliaOligonucleotide Array Sequence AnalysisStress, PhysiologicalSynapsesSynaptic TransmissionTranscription FactorsTranscription, GeneticVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsPostnatal hypoxiaCerebral maturationGlial maturationNewborn brainSynaptic maturationPresynaptic functionPostsynaptic functionSublethal hypoxiaSynaptic developmentHealth crisisHypoxiaCognitive disabilitiesBrainMaturation programMaturationDysynchronyNeuropathologyInfantsNeurotransmissionCohortProtein assaysMiceHypoxic
2000
PECAM-1 (CD31) Expression Modulates Bleeding Time in Vivo
Mahooti S, Graesser D, Patil S, Newman P, Duncan G, Mak T, Madri J. PECAM-1 (CD31) Expression Modulates Bleeding Time in Vivo. American Journal Of Pathology 2000, 157: 75-81. PMID: 10880378, PMCID: PMC1850208, DOI: 10.1016/s0002-9440(10)64519-1.Peer-Reviewed Original ResearchConceptsPECAM-1-deficient micePECAM-1Endothelial cellsNormal bleeding timeWild-type miceHematopoietic precursorsPolymorphonuclear leukocyte (PMN) transmigrationPECAM-1 expressionBleeding timePolymorphonuclear leukocytesAdjacent endothelial cellsMiceEndothelial cell migrationLeukocyte transmigrationBlood elementsExpression modulatesThrombosisPECAM-1 functions
1993
Functional CD4 T cell subset interplay in an intact immune system.
Murray J, Madri J, Pasqualini T, Bottomly K. Functional CD4 T cell subset interplay in an intact immune system. The Journal Of Immunology 1993, 150: 4270-6. PMID: 8097751, DOI: 10.4049/jimmunol.150.10.4270.Peer-Reviewed Original ResearchConceptsCD4 T cellsTh-2 cellsT cellsIL-5Antibody formationIFN-gammaTh-2-like cellsF1 hybrid T cellsIntact immune systemTh-1 cellsGood proliferative responsesCollagen IVCell primingProliferative responseImmune systemTh-1Hybrid miceMiceGamma treatmentAdditional studiesHuman collagen IVImmunizationSelective activationVivoCells
1992
Major histocompatibility complex (MHC) control of CD4 T cell subset activation. II. A single peptide induces either humoral or cell‐mediated responses in mice of distinct MHC genotype
Murray J, Pfeiffer C, Madri J, Bottomly K. Major histocompatibility complex (MHC) control of CD4 T cell subset activation. II. A single peptide induces either humoral or cell‐mediated responses in mice of distinct MHC genotype. European Journal Of Immunology 1992, 22: 559-565. PMID: 1347015, DOI: 10.1002/eji.1830220239.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibody FormationAntigen-Presenting CellsCD4-Positive T-LymphocytesCollagenGenes, MHC Class IIHaptensHumansImmunity, CellularImmunologic MemoryLymph NodesLymphocyte ActivationLymphocyte CooperationMajor Histocompatibility ComplexMiceMolecular Sequence DataPeptidesT-Lymphocytes, Helper-Inducer
1989
MHC control of CD4+ T cell subset activation.
Murray J, Madri J, Tite J, Carding S, Bottomly K. MHC control of CD4+ T cell subset activation. Journal Of Experimental Medicine 1989, 170: 2135-2140. PMID: 2573684, PMCID: PMC2189542, DOI: 10.1084/jem.170.6.2135.Peer-Reviewed Original ResearchConceptsT cellsIL-2IL-4-producing CD4T cell subset activationIL-4-producing cellsI-Ab miceMHC class II haplotypesCytokine-producing CD4T-cell phenotypeTypes of CD4Secondary IgG responsesClass II MHCSelective activationClass II haplotypesMHC controlSuch selective activationCytokine phenotypeIgG responsesSubset activationII MHCImmune responseProliferative responseCD4Vivo responseMice
1987
Inverse Ir gene control of the antibody and T cell proliferative responses to human basement membrane collagen.
Tite J, Foellmer H, Madri J, Janeway C. Inverse Ir gene control of the antibody and T cell proliferative responses to human basement membrane collagen. The Journal Of Immunology 1987, 139: 2892-8. PMID: 3117879, DOI: 10.4049/jimmunol.139.9.2892.Peer-Reviewed Original ResearchConceptsT cell proliferative responsesCell proliferative responsesAntibody responseIr gene controlProliferative responseT cellsHigher antibody responseClass II MHCMHC congenic miceMajor histocompatibility complexImmunologic responsivenessResponder parentF1 miceII MHCDifferent MHC genotypesImmune responseType IV collagenCongenic miceMiceHistocompatibility complexIV collagenDifferential activationAntigenBasement membrane collagenMHC genotype
1981
The immune response to human type III and type V (AB2) collagen: antigenic determinants and genetic control in mice
Kemp J, Madri J. The immune response to human type III and type V (AB2) collagen: antigenic determinants and genetic control in mice. European Journal Of Immunology 1981, 11: 90-94. PMID: 6163643, DOI: 10.1002/eji.1830110205.Peer-Reviewed Original ResearchConceptsAntibody responseSpecific IgG antibody responseAntigenic determinantsIgG antibody responseHigher antibody responseT cell recognitionType IIIType IHuman type IIIHigh-affinity monoclonal antibodiesAntigen presentationImmune responseBovine collagen type IMonoclonal antibodiesCollagen type IIr genesType V collagenCell recognitionHuman collagenFurther studiesConnective tissue biologyTissue biologyMicePresent studyCollagen