2001
pp60c-src Modulates Microvascular Endothelial Phenotype and in Vitro Angiogenesis
Marx M, Warren S, Madri J. pp60c-src Modulates Microvascular Endothelial Phenotype and in Vitro Angiogenesis. Experimental And Molecular Pathology 2001, 70: 201-213. PMID: 11417999, DOI: 10.1006/exmp.2001.2358.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAnimalsBecaplerminCell DivisionEndothelium, VascularGenes, srcGenetic VectorsMaleMicrocirculationMoloney murine leukemia virusNeovascularization, PhysiologicPlatelet-Derived Growth FactorProto-Oncogene Proteins c-sisProto-Oncogene Proteins pp60(c-src)RatsRecombinant ProteinsSignal TransductionTransfectionConceptsC-Src mutantC-SrcTwo-dimensional cultureThree-dimensional cultureWild-type c-SrcC-Src kinase activityC-Src tyrosine kinaseC-Src associatesC-src proteinPlatelet-derived growth factor receptorV-SrcPDGF signalCytoskeletal organizationGrowth factor receptorKinase activityCell shapeTyrosine kinaseVitro AngiogenesisTube-like structuresCell morphologyFactor receptorTube formationMutantsRegulatory effectsOverexpression
1995
Modulation of cell spreading and migration by pp125FAK phosphorylation.
Sankar S, Mahooti-Brooks N, Hu G, Madri J. Modulation of cell spreading and migration by pp125FAK phosphorylation. American Journal Of Pathology 1995, 147: 601-8. PMID: 7677174, PMCID: PMC1870973.Peer-Reviewed Original ResearchConceptsPp125FAK tyrosine phosphorylationTyrosine phosphorylationCell migrationCell spreadingIntegrin-mediated signalingFocal adhesion kinaseKinase-negative mutantPp125FAK phosphorylationAdhesion kinaseMigration ratePhosphorylationCascade pathwayFaster migration rateControl cellsSlower migration rateType I collagenEnhanced levelsCellsI collagenFibronectinMigrationPp125FAKMutantsKinaseSignaling