2017
Increased Oxidative Stress and Hypoxia Inducible Factor-1 Expression during Arteriovenous Fistula Maturation
Sadaghianloo N, Yamamoto K, Bai H, Tsuneki M, Protack CD, Hall MR, Declemy S, Hassen-Khodja R, Madri J, Dardik A. Increased Oxidative Stress and Hypoxia Inducible Factor-1 Expression during Arteriovenous Fistula Maturation. Annals Of Vascular Surgery 2017, 41: 225-234. PMID: 28163173, PMCID: PMC5411319, DOI: 10.1016/j.avsg.2016.09.014.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaArteriovenous Shunt, SurgicalGene Expression RegulationHeme Oxygenase-1Hydrogen PeroxideHyperplasiaHypoxia-Inducible Factor 1, alpha SubunitMaleMembrane ProteinsMice, Inbred C57BLNADPH Oxidase 2NeointimaOxidative StressReactive Oxygen SpeciesSignal TransductionTime FactorsTyrosineVascular Endothelial Growth Factor AVascular PatencyVena Cava, InferiorConceptsHeme oxygenase-1Arteriovenous fistulaAVF maturationNOX-2HIF-1αOxidative stressHypoxia-inducible factor 1 (HIF-1) expressionSham-operated micePoor clinical resultsHIF-1α immunoreactivityInferior vena cavaArteriovenous fistula maturationVascular endothelial growth factorHypoxia-inducible factor-1 (HIF-1) pathwayFactor-1 expressionEndothelial growth factorHIF-1 pathwayHuman AVF maturationQuantitative polymerase chain reactionOxidative stress increasesAortocaval fistulaFistula maturationVena cavaClinical resultsPolymerase chain reaction
2011
Brain regional angiogenic potential at the neurovascular unit during normal aging
Murugesan N, Demarest TG, Madri JA, Pachter JS. Brain regional angiogenic potential at the neurovascular unit during normal aging. Neurobiology Of Aging 2011, 33: 1004.e1-1004.e16. PMID: 22019053, PMCID: PMC3266473, DOI: 10.1016/j.neurobiolaging.2011.09.022.Peer-Reviewed Original ResearchConceptsNeurovascular unitPhysical exerciseNormal agingPolymerase chain reactionAngiogenesis-associated genesDiscrete brain regionsRegion-dependent wayReal-time polymerase chain reactionWeak angiogenic responseRegion-dependent mannerQuantitative real-time polymerase chain reactionCerebral angiogenesisAged brainAged miceLaser capture microdissectionTherapeutic benefitAge-related trendsBrain regionsAngiogenic capacityAngiogenic responseAngiogenic potentialChain reactionCapture microdissectionBrainHypoxia