2013
The mouse aortocaval fistula recapitulates human arteriovenous fistula maturation
Yamamoto K, Protack CD, Tsuneki M, Hall MR, Wong DJ, Lu DY, Assi R, Williams WT, Sadaghianloo N, Bai H, Miyata T, Madri JA, Dardik A. The mouse aortocaval fistula recapitulates human arteriovenous fistula maturation. AJP Heart And Circulatory Physiology 2013, 305: h1718-h1725. PMID: 24097429, PMCID: PMC3882542, DOI: 10.1152/ajpheart.00590.2013.Peer-Reviewed Original ResearchConceptsArteriovenous fistulaMaturation failureHigh-resolution Doppler ultrasoundArteriovenous fistula maturationFirst animal modelMature arteriovenous fistulaSmooth muscle cellsHuman AVF maturationAVF maturationAortocaval fistulaAVF failureFistula maturationImmediate thrombosisVenous adaptationExcellent patencyDoppler ultrasoundAnimal modelsDay 21Human patientsNeedle punctureDay 42Muscle cellsFistulaArterial environmentFailure
2011
A critical role for macrophages in neovessel formation and the development of stenosis in tissue‐engineered vascular grafts
Hibino N, Yi T, Duncan DR, Rathore A, Dean E, Naito Y, Dardik A, Kyriakides T, Madri J, Pober JS, Shinoka T, Breuer CK. A critical role for macrophages in neovessel formation and the development of stenosis in tissue‐engineered vascular grafts. The FASEB Journal 2011, 25: 4253-4263. PMID: 21865316, PMCID: PMC3236622, DOI: 10.1096/fj.11-186585.Peer-Reviewed Original ResearchConceptsMacrophage infiltrationNeovessel formationGraft-related complicationsIncidence of stenosisTissue-engineered vascular graftsDevelopment of stenosisTransgenic mouse modelRole of macrophagesFirst clinical trialSmooth muscle cellsVascular graftsTEVG stenosisMacrophage infiltratesClodronate liposomesClinical trialsM1 macrophagesM2 phenotypeMurine modelMouse modelStenosisSeeded graftsRole of cellNatural historyMuscle cellsMacrophages
1996
Role of plasminogen activator inhibitor in the reciprocal regulation of bovine aortic endothelial and smooth muscle cell migration by TGF-beta 1.
Petzelbauer E, Springhorn J, Tucker A, Madri J. Role of plasminogen activator inhibitor in the reciprocal regulation of bovine aortic endothelial and smooth muscle cell migration by TGF-beta 1. American Journal Of Pathology 1996, 149: 923-31. PMID: 8780396, PMCID: PMC1865168.Peer-Reviewed Original ResearchConceptsVascular cell typesCell typesSmooth muscle cellsPlasminogen activator inhibitorMuscle cellsAnti-catalytic antibodyActivator inhibitorExtracellular matrix componentsMigratory rateVascular smooth muscle cellsEndothelial cellsSmooth muscle cell migrationUrokinase plasminogen activatorMigratory behaviorReciprocal regulationMuscle cell migrationStable transfectantsCell migrationExtracellular matrixIntegrin synthesisMatrix componentsMigratory responseProteolytic phenotypeProteolytic activityGrowth factor
1993
Photoinhibition of smooth muscle cell migration: Potential therapy for restenosis
Deckelbaum L, Scott J, Stetz M, O'Brien K, Sumpio B, Madri J, Bell L. Photoinhibition of smooth muscle cell migration: Potential therapy for restenosis. Lasers In Surgery And Medicine 1993, 13: 4-11. PMID: 8426525, DOI: 10.1002/lsm.1900130104.Peer-Reviewed Original ResearchConceptsSmooth muscle cell migrationMuscle cell migrationLow energy light irradiationNeointima formationBroadband white lightCell migrationLight irradiationIncidence of restenosisLuminal cross-sectional areaSmooth muscle cell monolayersSmooth muscle cellsFibrointimal thickeningArterial injuryPotential therapyDaily radiant exposureRadiant exposureMuscle cellsThymidine incorporationRestenosisCross-sectional areaMigration of cellsCell proliferationCell monolayersMigration kineticsWhite light
1992
Modulation of vascular cell behavior by transforming growth factors β
Madri J, Bell L, Merwin J. Modulation of vascular cell behavior by transforming growth factors β. Molecular Reproduction And Development 1992, 32: 121-126. PMID: 1637550, DOI: 10.1002/mrd.1080320207.Peer-Reviewed Original ResearchConceptsVascular cell typesCell typesCellular responsesCell surfaceTGF-beta receptorsVascular cell behaviorGrowth factor βDistinct bioassaysDifferent isoformsCell migrationCell behaviorInhibition of proliferationVascular cell responsesSmooth muscle cellsUnique binding profileAngiogenic assaysIsoformsBinding profileCell populationsBovine aortic endothelialFactor βMuscle cellsType IBASMCsAortic endothelialMatrix composition, organization and soluble factors: Modulators of microvascular cell differentiation in vitro
Madri J, Marx M. Matrix composition, organization and soluble factors: Modulators of microvascular cell differentiation in vitro. Kidney International 1992, 41: 560-565. PMID: 1573829, DOI: 10.1038/ki.1992.82.Peer-Reviewed Original ResearchConceptsCell typesStructure/functionMajor cell typesExtracellular matrix componentsVascular cell behaviorVascular smooth muscle cellsEndothelial cellsCell differentiationSoluble factorsCell behaviorExtracellular matrixNeighboring cellsMetabolic functionsDirect interactionSmooth muscle cellsMatrix componentsCell populationsMorphological organizationMuscle cellsMicrovascular endothelial cellsCulture modelCellsMesangial cell populationOrgan culture modelCell isolationInteractions of Matrix Components and Soluble Factors in Vascular Responses to Injury
Madri J, Merwin J, Bell L, Basson C, Kocher O, Perlmutter R, Prinz C. Interactions of Matrix Components and Soluble Factors in Vascular Responses to Injury. 1992, 11-30. DOI: 10.1007/978-1-4899-0721-9_2.Peer-Reviewed Original ResearchSmooth muscle cellsMuscle cellsEndothelial cellsMatrix componentsSheet migrationWall integrityLarge vessel endothelial cellsExtracellular matrixVessel wall integrityVascular cellsVessel endothelial cellsActive endothelial cellsMetabolic activityMicrovascular endothelial cellsInterstitial stromaMedial smooth muscle cellsCellsDenudation injuryClose association
1991
Vascular cell responses to a hybrid Transforming Growth Factor-Beta molecule
Merwin J, Tucker A, Madisen L, Purchio A, Madri J. Vascular cell responses to a hybrid Transforming Growth Factor-Beta molecule. Biochemical And Biophysical Research Communications 1991, 175: 589-595. PMID: 1708238, DOI: 10.1016/0006-291x(91)91606-d.Peer-Reviewed Original ResearchEffects of soluble factors and extracellular matrix components on vascular cell behavior in vitro and in vivo: Models of de‐endothelialization and repair
Madri J, Marx M, Merwin J, Basson C, Prinz C, Bell L. Effects of soluble factors and extracellular matrix components on vascular cell behavior in vitro and in vivo: Models of de‐endothelialization and repair. Journal Of Cellular Biochemistry 1991, 45: 123-130. PMID: 1711525, DOI: 10.1002/jcb.240450202.Peer-Reviewed Original ResearchConceptsSoluble factorsEndothelial cellsVascular smooth muscle cellsCell populationsSite of injuryMicrovascular endothelial cellsSmooth muscle cellsVessel endothelial cellsEndothelial vascular cellsLarge vessel endothelial cellsVascular cell populationsCell typesIntimal thickeningDenudation injuryVascular cell typesArterial mediaSubsequent lumen formationDifferent cell populationsInjuryCell responsesMuscle cellsVascular cellsExtracellular matrixSoft tissueVascular cell behaviorVascular Cell Responses to TGF-β3 Mimic Those of TGF-β1 in vitro
Merwin J, Roberts A, Kondaiah P, Tucker A, Madri J. Vascular Cell Responses to TGF-β3 Mimic Those of TGF-β1 in vitro. Growth Factors 1991, 5: 149-158. PMID: 1768438, DOI: 10.3109/08977199109000279.Peer-Reviewed Original ResearchEndothelial Cell — Extracellular Matrix Interactions: Modulation of Vascular Cell Phenotype by Matrix Components and Soluble Factors
Madri J. Endothelial Cell — Extracellular Matrix Interactions: Modulation of Vascular Cell Phenotype by Matrix Components and Soluble Factors. Altschul Symposia Series 1991, 127-135. DOI: 10.1007/978-1-4615-3754-0_10.Peer-Reviewed Original ResearchCell typesExtracellular matrixVascular cell populationsComplex extracellular matrixCell populationsVascular cell typesVascular cell phenotypeResident cell typesSheet migrationLarge vessel endothelial cellsDiverse functionsVascular smooth muscle cellsEndothelial cellsLumen formationDifferent cell populationsSoluble factorsMatrix biosynthesisSmooth muscle cellsCell phenotypeVessel endothelial cellsTube formationMatrix componentsMuscle cellsRepair processSite of injuryVascular cells respond differentially to transforming growth factors beta 1 and beta 2 in vitro.
Merwin J, Newman W, Beall L, Tucker A, Madri J. Vascular cells respond differentially to transforming growth factors beta 1 and beta 2 in vitro. American Journal Of Pathology 1991, 138: 37-51. PMID: 1846264, PMCID: PMC1886039.Peer-Reviewed Original ResearchConceptsBovine aortic endothelial cellsBovine aortic smooth muscle cellsGrowth factorGrowth factor beta 1Aortic smooth muscle cellsTGF-beta concentrationsSmooth muscle cellsProliferation of BAECsTGF-beta receptorsBovine aortic endothelial cell migrationType IAortic endothelial cellsTGF beta sCell typesMicrovascular endotheliumVascular cell typesReceptor assayMuscle cellsVascular cellsEndothelial cellsBeta 1Endothelial cell migrationBeta 2Angiogenic assaysBASMCs
1990
Alternative splicing of endothelial cell fibronectin mRNA in the IIICS region. Functional significance.
Kocher O, Kennedy S, Madri J. Alternative splicing of endothelial cell fibronectin mRNA in the IIICS region. Functional significance. American Journal Of Pathology 1990, 137: 1509-24. PMID: 2260635, PMCID: PMC1877716.Peer-Reviewed Original ResearchConceptsAlternative splicingIIICS regionBovine aortic endothelial cellsHuman umbilical vein endothelial cell cDNA libraryRecombinant proteinsEndothelial cell cDNA libraryCell cDNA librarySpecific gene expressionSmooth muscle cellsAortic endothelial cellsEndothelial cellsMuscle cellsB16F10 melanoma cellsMelanoma cellsVascular cell functionCell attachmentFibronectin mRNACDNA clonesCDNA libraryRGDS sequenceGene expressionDNA fragmentsSplicingSequence analysisDifferent cell populationsInfluence of the angiotensin system on endothelial and smooth muscle cell migration.
Bell L, Madri J. Influence of the angiotensin system on endothelial and smooth muscle cell migration. American Journal Of Pathology 1990, 137: 7-12. PMID: 2164777, PMCID: PMC1877705.Peer-Reviewed Original ResearchConceptsSmooth muscle cell migrationVessel wall responseMuscle cell migrationBovine aortic endothelial cellsAortic smooth muscle cell migrationMedial smooth muscle cellsEndothelial cellsAngiotensin system componentsIle8-angiotensin IIEnzyme inhibitor lisinoprilSmooth muscle cellsCell migrationAortic endothelial cellsAngiotensin systemAngiotensin-converting enzyme inhibitor lisinoprilInhibitor lisinoprilLuminal sizeVessel functionMuscle cellsCell monolayersInjuryCultured cell monolayersPresent studyImportant determinantCells
1989
Effect of platelet factors on migration of cultured bovine aortic endothelial and smooth muscle cells.
Bell L, Madri J. Effect of platelet factors on migration of cultured bovine aortic endothelial and smooth muscle cells. Circulation Research 1989, 65: 1057-1065. PMID: 2791219, DOI: 10.1161/01.res.65.4.1057.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsPlatelet-derived growth factorSMC proliferationPlatelet factorEC proliferationMuscle cellsGrowth factorEndothelial cell injuryMechanism of actionVascular injuryVascular diseaseCell injurySMC migrationBovine aortic ECsAortic ECsInjuryNorepinephrineProliferationHistaminePresent studyResponse of ECPhenoxybenzamineKetanserinCellsAtherosclerosisModulation of actin mRNAs in cultured vascular cells by matrix components and TGF-β1
Kocher O, Madri J. Modulation of actin mRNAs in cultured vascular cells by matrix components and TGF-β1. In Vitro Cellular & Developmental Biology 1989, 25: 424-434. PMID: 2659578, DOI: 10.1007/bf02624627.Peer-Reviewed Original ResearchConceptsTwo-dimensional cultureActin mRNAEndothelial cell populationSmooth muscle cellsIndividual extracellular matrix proteinsSmooth muscle cell differentiationCell typesRat capillary endothelial cellsMuscle cell differentiationActin mRNA expressionThree-dimensional type ISkeletal muscle cellsMatrix componentsExtracellular matrix proteinsCell populationsCytoplasmic actin mRNAsMuscle actin mRNAEndothelial cellsMuscle cellsSmooth muscle cell markersExtracellular matrix componentsCultured vascular cellsΑ-SM actinBovine aortic endothelial cellsMuscle cell markersThe Interactions of Vascular Cells with Solid Phase (Matrix) and Soluble Factors
Madri J, Kocher O, Merwin J, Bell L, Yannariello-Brown J. The Interactions of Vascular Cells with Solid Phase (Matrix) and Soluble Factors. Journal Of Cardiovascular Pharmacology 1989, 14: s70-s75. DOI: 10.1097/00005344-198900146-00015.Peer-Reviewed Original ResearchVascular bedSoluble factorsVascular cellsEndothelial cellsVascular smooth muscle cellsCell populationsSite of injuryMicrovascular endothelial cellsSmooth muscle cellsVessel endothelial cellsLarge vessel endothelial cellsVascular cell populationsVascular injuryIntimal thickeningInjury variesPlatelet factorInjuryMuscle cellsSoft tissueTube formationVessel wallHeterogeneous cell populationsCell typesCellsRepair processThe Interactions of Vascular Cells with Solid Phase (Matrix) and Soluble Factors
Madri J, Kocher O, Merwin J, Bell L, Yannariello-Brown J. The Interactions of Vascular Cells with Solid Phase (Matrix) and Soluble Factors. Journal Of Cardiovascular Pharmacology 1989, 14: s70-s75. PMID: 2478828, DOI: 10.1097/00005344-198906146-00015.Peer-Reviewed Original ResearchConceptsVascular bedSoluble factorsVascular cellsEndothelial cellsVascular smooth muscle cellsCell populationsSite of injuryMicrovascular endothelial cellsSmooth muscle cellsVessel endothelial cellsLarge vessel endothelial cellsVascular cell populationsVascular injuryIntimal thickeningInjury variesPlatelet factorInjuryMuscle cellsSoft tissueTube formationVessel wallHeterogeneous cell populationsCell typesCellsRepair process