1998
Distinct signal transduction pathways are utilized during the tube formation and survival phases of in vitro angiogenesis
Ilan N, Mahooti S, Madri J. Distinct signal transduction pathways are utilized during the tube formation and survival phases of in vitro angiogenesis. Journal Of Cell Science 1998, 111: 3621-3631. PMID: 9819353, DOI: 10.1242/jcs.111.24.3621.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisCalcium-Calmodulin-Dependent Protein KinasesCapillariesCell Culture TechniquesCell LineCell SurvivalCollagenEndothelial Growth FactorsEndothelium, VascularExtracellular MatrixHumansLymphokinesNeovascularization, PhysiologicPhosphatidylinositol 3-KinasesPhosphorylationProtein Kinase CProtein Serine-Threonine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-aktSignal TransductionTetradecanoylphorbol AcetateVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsHuman umbilical vein endothelial cellsAkt/PKB pathwayTube formationDistinct signal transduction pathwaysAkt/PKBSignal transduction pathwaysDifferent ECM proteinsCollagen gelsExtracellular matrix componentsPeptide growth factorsPKB pathwayProtein kinaseTransduction pathwaysMAP kinaseUmbilical vein endothelial cellsECM proteinsVein endothelial cellsNew blood vesselsPre-existing onesKinaseMajor groupsVivo angiogenesisRapid inductionMatrix componentsSurvival phase
1993
Differential induction of VCAM-1 on human iliac venous and arterial endothelial cells and its role in adhesion.
Hauser I, Johnson D, Madri J. Differential induction of VCAM-1 on human iliac venous and arterial endothelial cells and its role in adhesion. The Journal Of Immunology 1993, 151: 5172-85. PMID: 7693806, DOI: 10.4049/jimmunol.151.10.5172.Peer-Reviewed Original ResearchMeSH KeywordsAdultCell AdhesionCell Adhesion MoleculesCells, CulturedE-SelectinEndothelium, VascularFemaleHumansIliac ArteryIliac VeinIntercellular Adhesion Molecule-1Lymphocyte Function-Associated Antigen-1Middle AgedReceptors, Very Late AntigenRNA, MessengerTetradecanoylphorbol AcetateTumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1ConceptsArterial endothelial cellsICAM-1VCAM-1Venous endothelial cellsEndothelial cellsTNF-alphaU937 cell adhesionELAM-1VCAM-1 cell surface expressionTNF-alpha-induced VCAM-1 expressionAdhesion molecules VCAM-1ICAM-2U937 cellsAdhesion molecules ICAM-1TNF-alpha-induced expressionLate activation AgVCAM-1 expressionMolecules ICAM-1VCAM-1/VLAMonocyte-like cell line U937TNF-alpha treatmentVessel endothelial cellsAdhesion of PMALarge vessel endothelial cellsEC types